Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Althea Goosen"'
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Autonomic Control of Heart Rate and QT Interval Variability Influences Arrhythmic Risk in Long QT Syndrome Type 1
Autor: Giulia Girardengo, Alfred L. George, Lia Crotti, Alberto Porta, Althea Goosen, Paul A. Brink, Peter J. Schwartz, Vlasta Bari
Publikováno v: J. Am. Coll. Cardiol. 65, 367-374 (2015)
BACKGROUND: A puzzling feature of the long QT syndrome (LQTS) is that family members carrying the same mutation often have divergent symptoms and clinical outcomes. OBJECTIVES: This study tested the hypothesis that vagal and sympathetic control, as a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0eada9830c7111c7ea728c29c96937f
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3
Long QT syndrome in South Africa : the results of comprehensive genetic screening : cardiovascular topic
Autor: Durrheim Ga, Valerie A. Corfield, Birgitte Støvring, Paula L. Hedley, Cathrine Jespersgaard, Paul A. Brink, Michael Christiansen, Tam Thanh Pham, Althea Goosen, Firzana Hendricks
Publikováno v: Cardiovascular Journal Of Africa. 24:231-237
Congenital long QT syndrome (cLQTS) is a genetic disorder predisposing to ventricular arrhythmia, syncope and sudden death. Over 700 different cLQTS-causing mutations in 13 genes are known. The genetic spectrum of LQTS in 44 South African cLQTS patie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c36e09a2f22ce898b29f57d4dbeac976
https://doi.org/10.5830/cvja-2013-032
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6
Vagal Reflexes Following an Exercise Stress Test
Autor: Maria Teresa La Rovere, Lia Crotti, Marshall Heradien, Paul A. Brink, Federica Dagradi, Carla Spazzolini, Peter J. Schwartz, Alessandro Vicentini, Erika Taravelli, Barbara Petracci, Alessandra P. Porretta, Alfred L. George, Althea Goosen, Matteo Pedrazzini, Emilio Vanoli
Publikováno v: Journal of the American College of Cardiology. 60:2515-2524
Objectives: The study assessed whether heart rate (HR) reduction following an exercise stress test (ExStrT), an easily quantifiable marker of vagal reflexes, might identify high- and low-risk long ...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90dc2607c5b79d232488d22d68f7eb1e
https://doi.org/10.1016/j.jacc.2012.08.1009
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7
Genetic variation in angiotensin II type 2 receptor gene influences extent of left ventricular hypertrophy in hypertrophic cardiomyopathy independent of blood pressure
Autor: Paul A. Brink, Marshall Heradien, Nadia Carstens, Johanna C. Moolman-Smook, Miriam Revera, Lize van der Merwe, Althea Goosen
Publikováno v: Journal of the Renin-Angiotensin-Aldosterone System, Vol 12 (2011)
Introduction. Hypertrophic cardiomyopathy (HCM), an inherited primary cardiac disorder mostly caused by defective sarcomeric proteins, serves as a model to investigate left ventricular hypertrophy (LVH). HCM manifests extreme variability in the degre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324cdb1e0be83f7fc3b44a2f470512d8
https://doi.org/10.1177/1470320310390725
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8
Abnormal blood pressure response to exercise occurs more frequently in hypertrophic cardiomyopathy patients with the R92W troponin T mutation than in those with myosin mutations
Autor: Marshall Heradien, Bongani M. Mayosi, Valerie A. Corfield, Lize van der Merwe, Johanna C. Moolman-Smook, Paul A. Brink, Althea Goosen, Miriam Revera
Publikováno v: Heart Rhythm
Abnormal blood pressure response to exercise is reported to occur in up to a third of hypertrophic cardiomyopathy (HCM) cases and is associated with an increased risk of death, particularly in the young, but it is not known whether the HCM-causing mu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30df0787c7036738f152156ac76898cf
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9
NOS1AP Is a Genetic Modifier of the Long-QT Syndrome
Autor: Peter J. Schwartz, Paul A. Brink, Roberto Insolia, Maria Cristina Monti, Lia Crotti, Althea Goosen, David A. Greenberg, Anna L. Peljto, Alfred L. George
Publikováno v: Circulation. 120:1657-1663
Background— In congenital long-QT syndrome (LQTS), a genetically heterogeneous disorder that predisposes to sudden cardiac death, genetic factors other than the primary mutation may modify the probability of life-threatening events. Recent evidence
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2efb810340e638398f1379874f84309
https://doi.org/10.1161/circulationaha.109.879643
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10
Genetic variation in angiotensin-converting enzyme 2 gene is associated with extent of left ventricular hypertrophy in hypertrophic cardiomyopathy
Autor: Valerie A. Corfield, Althea Goosen, Marshall Heradien, Ruben Cloete, Lize van der Merwe, Johanna C. Moolman-Smook, Paul A. Brink, M. Revera
Publikováno v: Human Genetics
Hypertrophic cardiomyopathy, a common, inherited cardiac muscle disease, is primarily caused by mutations in sarcomeric protein-encoding genes and is characterized by overgrowth of ventricular muscle that is highly variable in extent and location. Th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52cfa06bac8fec7ffda87ce865043b27
https://doi.org/10.1007/s00439-008-0524-6
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