Desensitization of α2A-adrenoceptor signalling by modest levels of adrenaline is facilitated by β2-adrenoceptor-dependent GRK3 up-regulation

Autor: Bawa, Tasneem, Altememi, Ghazi F, Eikenburg, Douglas C, Standifer, Kelly M

(1) Adrenaline (ADR) and noradrenaline (NA) can simultaneously activate inhibitory alpha(2)- and stimulatory beta-adrenoceptors (AR). However, ADR and NA differ significantly in that ADR is a potent beta(2)-AR agonist while NA is not. Only recently h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::afec834b253901f1a828167929a1e3a6
https://europepmc.org/articles/PMC1573738/

Desensitization of alpha 2A-adrenoceptor signalling by modest levels of adrenaline is facilitated by beta 2-adrenoceptor-dependent GRK3 up-regulation.

Autor: Bawa, Tasneem, Altememi, Ghazi F, Eikenburg, Douglas C, Standifer, Kelly M

Publikováno v: British Journal of Pharmacology; Mar2003, Vol. 138 Issue 5, p921-931, 11p

The presence of beta2-adrenoceptors sensitizes alpha2A-adrenoceptors to desensitization after chronic epinephrine treatment.

Autor: Bawa-Khalfe T; Research Center for Cardiovascular Diseases, Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas-Houston Health Science Center, Houston, TX, USA. Tasneem.Bawa-Khalfe@uth.tmc.edu, Altememi GF, Mandyam CD, Schwarz LA, Eikenburg DC, Standifer KM

Publikováno v: BMC pharmacology [BMC Pharmacol] 2007 Dec 20; Vol. 7, pp. 16. Date of Electronic Publication: 2007 Dec 20.