Platelets interact with CD169+ macrophages and cDC1 and enhance liposome-induced CD8+ T cell responses

Autor: Joanna Grabowska, Valentine Léopold, Katarzyna Olesek, Maarten K. Nijen Twilhaar, Alsya J. Affandi, Mieke C. Brouwer, Ilse Jongerius, Admar Verschoor, Cees van Kooten, Yvette van Kooyk, Gert Storm, Cornelis van ‘t Veer, Joke M. M. den Haan

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Historically platelets are mostly known for their crucial contribution to hemostasis, but there is growing understanding of their role in inflammation and immunity. The immunomodulatory role of platelets entails interaction with pathogens, but also w

Externí odkaz: https://doaj.org/article/3541dcb491b24ae2993ad7cfff31a80a

Incorporation of Toll-Like Receptor Ligands and Inflammasome Stimuli in GM3 Liposomes to Induce Dendritic Cell Maturation and T Cell Responses

Autor: Maarten K. Nijen Twilhaar, Lucas Czentner, Rianne G. Bouma, Katarzyna Olesek, Joanna Grabowska, Aru Zeling Wang, Alsya J. Affandi, Saskia C. Belt, Hakan Kalay, Cornelus F. van Nostrum, Yvette van Kooyk, Gert Storm, Joke M. M. den Haan

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Cancer vaccination aims to activate immunity towards cancer cells and can be achieved by delivery of cancer antigens together with immune stimulatory adjuvants to antigen presenting cells (APC). APC maturation and antigen processing is a subsequent p

Externí odkaz: https://doaj.org/article/42a73ed18e1e4c2ba3e4049a3d626210

Optimization of Liposomes for Antigen Targeting to Splenic CD169+ Macrophages

Autor: Maarten K. Nijen Twilhaar, Lucas Czentner, Joanna Grabowska, Alsya J. Affandi, Chun Yin Jerry Lau, Katarzyna Olesek, Hakan Kalay, Cornelus F. van Nostrum, Yvette van Kooyk, Gert Storm, Joke M.M. den Haan

Publikováno v: Pharmaceutics, Vol 12, Iss 12, p 1138 (2020)

Despite promising progress in cancer vaccination, therapeutic effectiveness is often insufficient. Cancer vaccine effectiveness could be enhanced by targeting vaccine antigens to antigen-presenting cells, thereby increasing T-cell activation. CD169-e

Externí odkaz: https://doaj.org/article/c0d3184f75cd44758488f01fcfbdc0be

Nuclear Receptor Subfamily 4A Signaling as a Key Disease Pathway of CD1c + Dendritic Cell Dysregulation in Systemic Sclerosis

Autor: Tiago Carvalheiro, Marzia Rossato, Marta Cossu, Catherina G.K. Wichers, Lorenzo Beretta, Eleni Chouri, Jonas J.W. Kuiper, Femke Bonte-Minheur, Sandra C Silva-Cardoso, Nila H. Servaas, Anneline C Hinrichs, Timothy R D J Radstake, Aridaman Pandit, Nadia Vazirpanah, Alsya J. Affandi, Maarten van der Kroef, Cornelis P. J. Bekker, Andrea Ottria, Marianne Boes, Sanne Hiddingh

Publikováno v: Arthritis and Rheumatology. John Wiley and Sons Ltd

ObjectivesTo identify key disease pathways driving conventional dendritic cell (cDC) alterations in Systemic Sclerosis (SSc).MethodsTranscriptomic profiling was performed on peripheral blood CD1c+ cDCs (cDC2s) isolated from 12 healthy donors and 48 S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f44e5944c3ffe699cec9a70c44ca8b1
https://doi.org/10.1002/art.42319

Liposome induction of CD8+ T cell responses depends on CD169+ macrophages and Batf3-dependent dendritic cells and is enhanced by GM3 inclusion

Autor: L. Klaase, Paul R. Crocker, M.K. Nijen Twilhaar, Katarzyna Olesek, D.A.M. Heijnen, Gert Storm, Martino Ambrosini, Alsya J. Affandi, J.M.M. den Haan, Andrés Hidalgo, K. Asano, Y van Kooyk, D. van Dinther, Joanna Grabowska, Leoni Hoogterp

Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)
Grabowska, J, Affandi, A J, van Dinther, D, Nijen Twilhaar, M K, Olesek, K, Hoogterp, L, Ambrosini, M, Heijnen, D A M, Klaase, L, Hidalgo, A, Asano, K, Crocker, P R, Storm, G, van Kooyk, Y & den Haan, J M M 2021, ' Liposome induction of CD8 + T cell responses depends on CD169 + macrophages and Batf3-dependent dendritic cells and is enhanced by GM3 inclusion ', Journal of Controlled Release, vol. 331, pp. 309-320 . https://doi.org/10.1016/j.jconrel.2021.01.029
Journal of controlled release : official journal of the Controlled Release Society, 331, 309. Elsevier
Journal of controlled release, 331, 309-320. Elsevier
Journal of Controlled Release, 331, 309-320. Elsevier

Cancer vaccines aim to efficiently prime cytotoxic CD8+ T cell responses which can be achieved by vaccine targeting to dendritic cells. CD169+ macrophages have been shown to transfer antigen to dendritic cells and could act as an alternative target f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd3465606d06b7513ccd028efc441eb
https://dspace.library.uu.nl/handle/1874/418106