Searching for Synthetic Opioid Rescue Agents: Identification of a Potent Opioid Agonist with Reduced Respiratory Depression.

Autor: Vu LY; Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40506, United States., Luo D; Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40506, United States.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40506, United States., Johnson K; Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40506, United States., Denehy ED; Department of Psychology, University of Kentucky, Lexington, Kentucky 40536, United States., Songrady JC; Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40506, United States., Martin J; Department of Psychology, University of Kentucky, Lexington, Kentucky 40536, United States., Trivedi R; Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40506, United States., Alsum AR; Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40506, United States., Shaykin JD; Department of Psychology, University of Kentucky, Lexington, Kentucky 40536, United States., Chaudhary CL; Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40506, United States.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40506, United States., Woloshin EJ; Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40506, United States., Kornberger L; Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40506, United States., Bhuiyan N; Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40506, United States.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40506, United States., Parkin S; Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States., Jiang Q; Center for Clinical Pharmacology, University of Health Sciences and Pharmacy and Washington University School of Medicine, St. Louis, Missouri 63110, United States., Che T; Center for Clinical Pharmacology, University of Health Sciences and Pharmacy and Washington University School of Medicine, St. Louis, Missouri 63110, United States., Alilain W; Spinal Cord and Brain Injury Research Center (SCoBIRC), College of Medicine, University of Kentucky, Lexington, Kentucky 40536, United States.; Department of Neuroscience, University of Kentucky, Lexington, Kentucky 40536, United States., Turner JR; Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40506, United States., Bardo MT; Department of Psychology, University of Kentucky, Lexington, Kentucky 40536, United States., Prisinzano TE; Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40506, United States.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40506, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Jun 13; Vol. 67 (11), pp. 9173-9193. Date of Electronic Publication: 2024 May 29.