The disordered N-terminal tail of SARS-CoV-2 Nucleocapsid protein forms a dynamic complex with RNA.

Autor: Cubuk J; Department of Biochemistry and Molecular Biophysics, Washington University in St Louis, 660 St Euclid Ave, 63110 Saint Louis, MO, USA.; Center for Biomolecular Condensates, Washington University in St Louis, 1 Brookings Drive, 63130 Saint Louis, MO, USA., Alston JJ; Department of Biochemistry and Molecular Biophysics, Washington University in St Louis, 660 St Euclid Ave, 63110 Saint Louis, MO, USA.; Center for Biomolecular Condensates, Washington University in St Louis, 1 Brookings Drive, 63130 Saint Louis, MO, USA., Incicco JJ; Department of Biochemistry and Molecular Biophysics, Washington University in St Louis, 660 St Euclid Ave, 63110 Saint Louis, MO, USA.; Center for Biomolecular Condensates, Washington University in St Louis, 1 Brookings Drive, 63130 Saint Louis, MO, USA., Holehouse AS; Department of Biochemistry and Molecular Biophysics, Washington University in St Louis, 660 St Euclid Ave, 63110 Saint Louis, MO, USA.; Center for Biomolecular Condensates, Washington University in St Louis, 1 Brookings Drive, 63130 Saint Louis, MO, USA., Hall KB; Department of Biochemistry and Molecular Biophysics, Washington University in St Louis, 660 St Euclid Ave, 63110 Saint Louis, MO, USA., Stuchell-Brereton MD; Department of Biochemistry and Molecular Biophysics, Washington University in St Louis, 660 St Euclid Ave, 63110 Saint Louis, MO, USA.; Center for Biomolecular Condensates, Washington University in St Louis, 1 Brookings Drive, 63130 Saint Louis, MO, USA., Soranno A; Department of Biochemistry and Molecular Biophysics, Washington University in St Louis, 660 St Euclid Ave, 63110 Saint Louis, MO, USA.; Center for Biomolecular Condensates, Washington University in St Louis, 1 Brookings Drive, 63130 Saint Louis, MO, USA.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2024 Mar 21; Vol. 52 (5), pp. 2609-2624.

Conserved molecular recognition by an intrinsically disordered region in the absence of sequence conservation.

Autor: Alston JJ, Soranno A, Holehouse AS

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Aug 07. Date of Electronic Publication: 2023 Aug 07.

The analytical Flory random coil is a simple-to-use reference model for unfolded and disordered proteins.

Autor: Alston JJ; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.; Center for Biomolecular Condensates, Washington University in St. Louis, St. Louis, MO, USA., Ginell GM; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.; Center for Biomolecular Condensates, Washington University in St. Louis, St. Louis, MO, USA., Soranno A; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.; Center for Biomolecular Condensates, Washington University in St. Louis, St. Louis, MO, USA., Holehouse AS; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.; Center for Biomolecular Condensates, Washington University in St. Louis, St. Louis, MO, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Mar 13. Date of Electronic Publication: 2023 Mar 13.

The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA.

Autor: Cubuk J; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.; Center for Science and Engineering of Living Systems (CSELS), Washington University in St. Louis, St. Louis, MO, USA., Alston JJ; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.; Center for Science and Engineering of Living Systems (CSELS), Washington University in St. Louis, St. Louis, MO, USA., Incicco JJ; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.; Center for Science and Engineering of Living Systems (CSELS), Washington University in St. Louis, St. Louis, MO, USA., Singh S; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.; Center for Science and Engineering of Living Systems (CSELS), Washington University in St. Louis, St. Louis, MO, USA., Stuchell-Brereton MD; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.; Center for Science and Engineering of Living Systems (CSELS), Washington University in St. Louis, St. Louis, MO, USA., Ward MD; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.; Center for Science and Engineering of Living Systems (CSELS), Washington University in St. Louis, St. Louis, MO, USA., Zimmerman MI; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.; Center for Science and Engineering of Living Systems (CSELS), Washington University in St. Louis, St. Louis, MO, USA., Vithani N; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.; Center for Science and Engineering of Living Systems (CSELS), Washington University in St. Louis, St. Louis, MO, USA., Griffith D; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.; Center for Science and Engineering of Living Systems (CSELS), Washington University in St. Louis, St. Louis, MO, USA., Wagoner JA; Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY, USA., Bowman GR; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.; Center for Science and Engineering of Living Systems (CSELS), Washington University in St. Louis, St. Louis, MO, USA., Hall KB; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA., Soranno A; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA. soranno@wustl.edu.; Center for Science and Engineering of Living Systems (CSELS), Washington University in St. Louis, St. Louis, MO, USA. soranno@wustl.edu., Holehouse AS; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA. alex.holehouse@wustl.edu.; Center for Science and Engineering of Living Systems (CSELS), Washington University in St. Louis, St. Louis, MO, USA. alex.holehouse@wustl.edu.

Publikováno v: Nature communications [Nat Commun] 2021 Mar 29; Vol. 12 (1), pp. 1936. Date of Electronic Publication: 2021 Mar 29.

Androgen receptor and chemokine receptors 4 and 7 form a signaling axis to regulate CXCL12-dependent cellular motility.

Autor: Hsiao JJ; Department of Molecular Physiology & Biophysics, The University of Iowa, Carver College of Medicine, 51 Newton Road, Iowa City, Iowa, 52242, USA. jordy-hsiao@uiowa.edu., Ng BH; Department of Molecular Physiology & Biophysics, The University of Iowa, Carver College of Medicine, 51 Newton Road, Iowa City, Iowa, 52242, USA. ng.brandonh@gmail.com., Smits MM; Department of Molecular Physiology & Biophysics, The University of Iowa, Carver College of Medicine, 51 Newton Road, Iowa City, Iowa, 52242, USA. melinda-smits@uiowa.edu., Wang J; Department of Molecular Physiology & Biophysics, The University of Iowa, Carver College of Medicine, 51 Newton Road, Iowa City, Iowa, 52242, USA. jiahui-wang@uiowa.edu., Jasavala RJ; Department of Pharmacology, Davis Genome Center, University of California Davis School of Medicine, One Shields Avenue, Davis, California, 95616, USA. rjasavala@gmail.com., Martinez HD; Department of Molecular Physiology & Biophysics, The University of Iowa, Carver College of Medicine, 51 Newton Road, Iowa City, Iowa, 52242, USA. harryl.martinez@gmail.com., Lee J; Department of Molecular Physiology & Biophysics, The University of Iowa, Carver College of Medicine, 51 Newton Road, Iowa City, Iowa, 52242, USA. jinhee-lee@uiowa.edu., Alston JJ; Department of Molecular Physiology & Biophysics, The University of Iowa, Carver College of Medicine, 51 Newton Road, Iowa City, Iowa, 52242, USA. jhu2@umbc.edu., Misonou H; Graduate School of Brain Science, Doshisha University, Kyoto, Japan. hmisono@mail.doshisha.ac.jp., Trimmer JS; Department of Neurobiology, Physiology and Behavior and Department of Physiology and Membrane Biology, University of California Davis, School of Medicine, One Shields Avenue, Davis, California, 95616, USA. jtrimmer@ucdavis.edu., Wright ME; Department of Molecular Physiology & Biophysics, The University of Iowa, Carver College of Medicine, 51 Newton Road, Iowa City, Iowa, 52242, USA. michael-e-wright@uiowa.edu.

Publikováno v: BMC cancer [BMC Cancer] 2015 Mar 31; Vol. 15, pp. 204. Date of Electronic Publication: 2015 Mar 31.