Anti-proliferative 2,3-dihydro-1,3,4-thiadiazoles targeting VEGFR-2: Design, synthesis, in vitro, and in silico studies.

Autor: Elkady H; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt., Elgammal WE; Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt., Mahdy HA; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt., Zara S; Department of Pharmacy, 'G. d'Annunzio' University of Chieti-Pescara, Chieti 66100, Italy., Carradori S; Department of Pharmacy, 'G. d'Annunzio' University of Chieti-Pescara, Chieti 66100, Italy., Husein DZ; Chemistry Department, Faculty of Science, New Valley University, El--Kharja 72511, Egypt., Alsfouk AA; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia., Ibrahim IM; Biophysics Department, Faculty of Science, Cairo University, Giza 12613, Egypt., Elkaeed EB; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, P.O. Box 71666, Riyadh 11597, Saudi Arabia; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.. Electronic address: ekaeed@um.edu.sa., Metwaly AM; Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt. Electronic address: ametwaly@azhar.edu.eg., Eissa IH; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt. Electronic address: Ibrahimeissa@azhar.edu.eg.

Publikováno v: Computational biology and chemistry [Comput Biol Chem] 2024 Sep 23; Vol. 113, pp. 108221. Date of Electronic Publication: 2024 Sep 23.

New thiazolidine-2,4-diones as potential anticancer agents and apoptotic inducers targeting VEGFR-2 kinase: Design, synthesis, in silico and in vitro studies.

Autor: Elkady H; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt. Electronic address: Hazemelkady@azhar.edu.eg., Mahdy HA; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt. Electronic address: hazem_hady2001@azhar.edu.eg., Taghour MS; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt., Dahab MA; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt., Elwan A; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt., Hagras M; Department of Pharmaceutical Organic Chemistry, College of Pharmacy, Al-Azhar University, Cairo 11884, Egypt. Electronic address: m.hagrs@Azhar.edu.eg., Hussein MH; Department of Pharmaceutical Organic Chemistry, College of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt., Ibrahim IM; Biophysics Department, Faculty of Science, Cairo University, Giza 12613, Egypt. Electronic address: ibrahim_mohamed@cu.edu.eg., Husein DZ; Chemistry Department, Faculty of Science, New Valley University, El-Kharja 72511, Egypt. Electronic address: dalal_husein@sci.nvu.edu.eg., Elkaeed EB; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh 13713, Saudi Arabia. Electronic address: ekaeed@um.edu.sa., Alsfouk AA; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. Electronic address: aaalsfouk@pnu.edu.sa., Metwaly AM; Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt; Biopharmaceutical Products Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Alexandria 21934, Egypt. Electronic address: ametwaly@azhar.edu.eg., Eissa IH; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt. Electronic address: Ibrahimeissa@azhar.edu.eg.

Publikováno v: Biochimica et biophysica acta. General subjects [Biochim Biophys Acta Gen Subj] 2024 Jun; Vol. 1868 (6), pp. 130599. Date of Electronic Publication: 2024 Mar 21.

Discovery and Anticancer Screening of Novel Oxindole-Based Derivative Bearing Pyridyl Group as Potent and Selective Dual FLT3/CDK2 Kinase Inhibitor.

Autor: Soudi A; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt., Bender O; Biotechnology Institute, Ankara University, Ankara 06135, Turkey., Celik I; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Erciyes University, Kayseri 38280, Turkey.; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, 06120 Halle, Germany., El-Hafeez AAA; Pharmacology and Experimental Oncology Unit, Department of Cancer Biology, National Cancer Institute, Cairo University, Cairo 11796, Egypt., Dogan R; Biotechnology Institute, Ankara University, Ankara 06135, Turkey., Atalay A; Biotechnology Institute, Ankara University, Ankara 06135, Turkey., Elkaeed EB; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh 13713, Saudi Arabia., Alsfouk AA; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia., Abdelhafez EMN; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt., Aly OM; Department of Medicinal Chemistry, Faculty of Pharmacy, Port Said University, Port Said 42511, Egypt., Sippl W; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, 06120 Halle, Germany., Ali TFS; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.

Publikováno v: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2024 May 20; Vol. 17 (5). Date of Electronic Publication: 2024 May 20.

New Theobromine Apoptotic Analogue with Anticancer Potential Targeting the EGFR Protein: Computational and In Vitro Studies.

Autor: Eissa IH; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt., Yousef RG; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt., Elkaeed EB; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh 13713, Saudi Arabia., Alsfouk AA; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia., Husein DZ; Chemistry Department, Faculty of Science, New Valley University, El-Kharja 72511, Egypt., Ibrahim IM; Biophysics Department, Faculty of Science, Cairo University, Giza 12613, Egypt., Ismail A; Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt., Elkady H; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt., Metwaly AM; Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.; Biopharmaceutical Products Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Alexandria 21934, Egypt.

Publikováno v: ACS omega [ACS Omega] 2024 Mar 27; Vol. 9 (14), pp. 15861-15881. Date of Electronic Publication: 2024 Mar 27 (Print Publication: 2024).

Rationale design and synthesis of new apoptotic thiadiazole derivatives targeting VEGFR-2: computational and in vitro studies.

Autor: Elgammal WE; Department of Chemistry, Faculty of Science, Al-Azhar University Nasr City Cairo Egypt., Elkady H; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University Cairo 11884 Egypt., Mahdy HA; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University Cairo 11884 Egypt., Husein DZ; Chemistry Department, Faculty of Science, New Valley University El-Kharja 72511 Egypt., Alsfouk AA; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University P.O. Box 84428 Riyadh 11671 Saudi Arabia., Alsfouk BA; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University P.O. Box 84428 Riyadh 11671 Saudi Arabia., Ibrahim IM; Biophysics Department, Faculty of Science, Cairo University Giza 12613 Egypt Ibrahim_mohamed@cu.edu.eg., Elkaeed EB; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University Riyadh 13713 Saudi Arabia ekaeed@um.edu.sa., Metwaly AM; Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University Cairo 11884 Egypt ametwaly@azhar.edu.eg.; Biopharmaceutical Products Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City) Alexandria Egypt., Eissa IH; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University Cairo 11884 Egypt.

Publikováno v: RSC advances [RSC Adv] 2023 Dec 19; Vol. 13 (51), pp. 35853-35876. Date of Electronic Publication: 2023 Dec 19 (Print Publication: 2023).