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New Evidence for P-gp-Mediated Export of Amyloid-β Peptides in Molecular, Blood-Brain Barrier and Neuronal Models

Autor: Amanda B. Chai, Xuexin Gao, Anika M.S. Hartz, Richard Callaghan, Ingrid C. Gelissen, Alryel Yang

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 246, p 246 (2021)
Volume 22
Issue 1

Defective clearance mechanisms lead to the accumulation of amyloid-beta (A&beta
) peptides in the Alzheimer&rsquo
s brain. Though predominantly generated in neurons, little is known about how these hydrophobic, aggregation-prone, and tightl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858e5f3d560af313a8fda830e03164ed
http://europepmc.org/articles/PMC7795149

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The Adaptor Protein Alix is Involved in the Interaction Between the Ubiquitin Ligase NEDD4-1 and its Targets, ABCG1 and ABCG4

Autor: Amjad Z. Alrosan, Ingrid C. Gelissen, Andrew J. Brown, Shereen M. Aleidi, Alryel Yang

Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 11, p 2714 (2019)
International Journal of Molecular Sciences
Volume 20
Issue 11

Several ATP-Binding Cassette (ABC) transporters, including ABCG1 and the related ABCG4, are essential regulators of cellular lipid homeostasis. ABCG1 is expressed ubiquitously and is functional in the context of atherosclerosis. However, ABCG4 is exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c3863644ff7367bb4dcb6bfff55bb76
https://www.mdpi.com/1422-0067/20/11/2714

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Regulation of ABCG4 transporter expression by sterols and LXR ligands

Autor: Amjad Z. Alrosan, Richard Callaghan, Alryel Yang, Ingrid C. Gelissen, Andrew J. Brown, Laura J. Sharpe

Publikováno v: Biochimica et Biophysica Acta (BBA) - General Subjects. 1865:129769

Background Oxysterols, which are derivatives of cholesterol produced by enzymic or non-enzymic pathways, are potent regulators of cellular lipid homeostasis. Sterol homeostasis in the brain is an important area of interest with regards to neurodegene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f2de6dd545cb1f026daa5dc1e80b76
https://doi.org/10.1016/j.bbagen.2020.129769

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[P1–178]: NEW INSIGHTS INTO THE ROLE OF ABC‐TRANSPORTERS IN AMYLOID‐BETA CLEARANCE FROM CELLS IN THE BRAIN

Autor: Ingrid C. Gelissen, Alryel Yang, Divya Muthiah, Richard Callaghan

Publikováno v: Alzheimer's & Dementia. 13

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2eace2eeafef2bbadb88e2441c60dcc7
https://doi.org/10.1016/j.jalz.2017.06.245

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The E3 ubiquitin ligase, HECTD1, is involved in ABCA1-mediated cholesterol export from macrophages

Autor: Shereen M. Aleidi, Ingrid C. Gelissen, Kerry-Anne Rye, Blake J. Cochran, Alryel Yang, Maaike Kockx, Laura J. Sharpe, Andrew J. Brown, Geetha Rao

Publikováno v: Biochimica et biophysica acta. Molecular and cell biology of lipids. 1863(4)

The ABC lipid transporters, ABCA1 and ABCG1, are essential for maintaining lipid homeostasis in cells such as macrophages by exporting excess cholesterol to extracellular acceptors. These transporters are highly regulated at the post-translational le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf6e9ad786913611d2dcb7f28ccf73f
https://pubmed.ncbi.nlm.nih.gov/29306077

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ABC-Transporter Mediated Sterol Export from Cells Using Radiolabeled Sterols

Autor: Alryel, Yang, Ingrid C, Gelissen

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1583

Cholesterol export from cells to extracellular acceptors represents the first step of the reverse cholesterol transport process and is an essential part of the multifaceted pathway for cells to control their cholesterol levels. Malfunction of this pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::59e089240a1bc9e4bda86033feac8aa8
https://pubmed.ncbi.nlm.nih.gov/28205181

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ABC-Transporter Mediated Sterol Export from Cells Using Radiolabeled Sterols

Autor: Ingrid C. Gelissen, Alryel Yang

Publikováno v: Methods in Molecular Biology ISBN: 9781493968732

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6ccccc4197141d9ab8dc044439724b88
https://doi.org/10.1007/978-1-4939-6875-6_20

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The E3 Ubiquitin Ligases, HUWE1 and NEDD4-1, Are Involved in the Post-translational Regulation of the ABCG1 and ABCG4 Lipid Transporters*

Autor: Ingrid C. Gelissen, Shereen M. Aleidi, Geetha Rao, Laura J. Sharpe, Vicky Howe, Alryel Yang, Andrew J. Brown

The ATP-binding cassette transporter ABCG1 has an essential role in cellular cholesterol homeostasis, and dysregulation has been associated with a number of high burden diseases. Previous studies reported that ABCG1 is ubiquitinated and degraded via

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e5e0aa1b0b843b229e6f40eac0991a
https://europepmc.org/articles/PMC4591838/

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