Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Alphonse Garcia"'
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e9981 (2010)
BACKGROUND: Previous studies established that PP1 is a target for Bcl-2 proteins and an important regulator of apoptosis. The two distinct functional PP1 consensus docking motifs, R/Kx((0,1))V/IxF and FxxR/KxR/K, involved in PP1 binding and cell deat
Externí odkaz:
https://doaj.org/article/60d5dc00c6234215a27f4ae8a3e7e098
Autor:
Angélique N Godet, Julien Guergnon, Amélie Croset, Xavier Cayla, Pierre Barthélemy Falanga, Jean-Hervé Colle, Alphonse Garcia
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e13760 (2010)
BACKGROUND: The hallmark of HIV-1 pathogenesis is the progressive CD4(+) T cell depletion and high propensity of CD4(+) T cells to apoptosis. HIV-1 viral protein R (Vpr) is a major pro-apoptotic gene product. A first Vpr-mediated apoptotic mechanism
Externí odkaz:
https://doaj.org/article/4229deeda11844bbae032625bd9e5a5a
Autor:
Alphonse Garcia, Bruno Périchon
Publikováno v:
Clinical Microbiology and Research. :1-4
Therapeutic strategies based on optimization of the unique human LL37 cathelecin sequences including FK16, the core active sequence of LL37, have already been proposed. In this study we have characterized TatIV13 a new host defense hybrid peptide, th
Publikováno v:
Biologics: Targets and Therapy. 13:117-126
Objective: The objective of this study was to test our Viral Quinta Columna Strategy (VQCS), a new biological hypothesis predicting that specific multifunctional virally encoded cationic domains may have the capacity to penetrate human cells and inte
Publikováno v:
Biologics : Targets & Therapy
Objective: The objective of this study was to test our Viral Quinta Columna Strategy (VQCS), a new biological hypothesis predicting that specific multifunctional virally encoded cationic domains may have the capacity to penetrate human cells and inte
Autor:
Alphonse Garcia A, Bruno Perichon
Publikováno v:
Journal of Biotechnology and Biomedicine.
Specific intracellular pathways regulated by Apolipoprotein E (ApoE), a PP2A activator or survivin, an inhibitor of Heat Shock Proteins (HSP), can impact human diseases including cancers. In this study, we have initially observed that anti-tumor Tat-
Autor:
Alphonse Garcia
Publikováno v:
Medical hypotheses. 113
Small viral proteins with cationic domains can be involved in multiple biological processes including cell penetration or interaction with intracellular targets. Within the last two decades several reports indicated that the C-terminus of HIV-1 Vpr i
Publikováno v:
World Journal of AIDS. :148-155
The virally encoded HIV-1 viral protein R (VPR) is a multifunctional factor that is required for induced HIV-1 pathogenesis. VPR is also a cell-penetrating protein found in biological fluids from HIV-1 infected individuals. In this regard, we previou
Autor:
Marie-Lise Thieulant, Ghislaine Garrel, Joëlle Cohen-Tannoudji, Xavier Cayla, Violaine Simon, Alphonse Garcia, Raymond Counis
Publikováno v:
Biology of Reproduction. 82:1170-1179
Previous in vivo studies have established that pituitary nitric oxide synthase type 1 (NOS1) is regulated by gonadotropin-releasing hormone (GnRH). The aim of our study was to elucidate the mechanisms of NOS1 regulation by GnRH in rat pituitary cells
Autor:
Xavier Cayla, Pierre Etienne Bost, Angelita Rebollo, Alphonse Garcia, Frederic Dessauge, Gordon Langsley, François Traincard, Julien Guergnon
Publikováno v:
Apoptosis
Apoptosis, Springer Verlag, 2006, 11 (8), pp.1263-1273. ⟨10.1007/s10495-006-7702-6⟩
Apoptosis, Springer Verlag, 2006, 11 (8), pp.1263-1273
Apoptosis, 2006, 11 (8), pp.1263-1273. ⟨10.1007/s10495-006-7702-6⟩
Apoptosis, Springer Verlag, 2006, 11 (8), pp.1263-1273. ⟨10.1007/s10495-006-7702-6⟩
Apoptosis, Springer Verlag, 2006, 11 (8), pp.1263-1273
Apoptosis, 2006, 11 (8), pp.1263-1273. ⟨10.1007/s10495-006-7702-6⟩
T. annulata, an intracellular pathogenic parasite of the Aplicomplexa protozoan family infects bovine B-lymphocytes and macrophages. Parasitized cells that become transformed survive and proliferate independently of exogenous growth factors. In the p