Zobrazeno 1 - 10
of 332
pro vyhledávání: '"Alpha emitter"'
Autor:
A. K. M. Rezaur Rahman, Mahathe Hasan Babu, Mustofa Khalid Ovi, Md. Mahiuddin Zilani, Israt Sultana Eithu, Amit Chakraborty
Publikováno v:
Journal of Medical Physics, Vol 49, Iss 2, Pp 137-147 (2024)
The utilization of actinium-225 (225Ac) radionuclides in targeted alpha therapy for cancer was initially outlined in 1993. Over the past two decades, substantial research has been conducted, encompassing the establishment of 225Ac production methods,
Externí odkaz:
https://doaj.org/article/fd3d3f7c0ce94a51827a26a032bbaa64
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-14 (2023)
Abstract Background Alpha-emitter radiopharmaceutical therapy (αRPT) has shown promising outcomes in metastatic disease. However, the short range of the alpha particles necessitates dosimetry on a near-cellular spatial scale. Current knowledge on ce
Externí odkaz:
https://doaj.org/article/4ba6d0cb63a7478ebf4195fef83dbf69
Autor:
Matthias Miederer, Martina Benešová-Schäfer, Constantin Mamat, David Kästner, Marc Pretze, Enrico Michler, Claudia Brogsitter, Jörg Kotzerke, Klaus Kopka, David A. Scheinberg, Michael R. McDevitt
Publikováno v:
Pharmaceuticals, Vol 17, Iss 1, p 76 (2024)
The use of radionuclides for targeted endoradiotherapy is a rapidly growing field in oncology. In particular, the focus on the biological effects of different radiation qualities is an important factor in understanding and implementing new therapies.
Externí odkaz:
https://doaj.org/article/25291905b7a14e40b287668ad107995a
Publikováno v:
Pharmaceuticals, Vol 16, Iss 12, p 1720 (2023)
Background: The combination of platinum-containing cytostatic drugs with different radiation qualities has been studied for years. Despite their massive side effects, these drugs still belong to the therapeutic portfolio in cancer treatment. To overc
Externí odkaz:
https://doaj.org/article/5a8f05bb2a0d4c1d897a766a25194817
Akademický článek
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Autor:
Stein Gunnar Larsen, Wilhelm Graf, Anthony Burton Mariathasan, Olaf Sørensen, Milan Spasojevic, Mariusz Adam Goscinski, Silje Selboe, Nadja Lundstrøm, Anne Holtermann, Mona-Elisabeth Revheim, Øyvind Sverre Bruland
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
BackgroundPeritoneal metastasis (PM) from colorectal cancer carries a dismal prognosis despite extensive cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC). With a median time to recurrence of 11–12 months, there is a n
Externí odkaz:
https://doaj.org/article/a8677dc49f144701a7b580b9fa722d54
Autor:
Simen Rykkje Grønningsæter, Johan Blakkisrud, Silje Selboe, Mona-Elisabeth Revheim, Øyvind Sverre Bruland, Tina Bjørnlund Bønsdorff, Stein Gunnar Larsen, Caroline Stokke
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
AimTwo ongoing phase I studies are investigating the use of radium-224 adsorbed to calcium carbonate micro particles (224Ra-CaCO3-MP) to treat peritoneal metastasis originating from colorectal or ovarian cancer. The aim of this work was to study the
Externí odkaz:
https://doaj.org/article/b0d173692f8d4056b9aa21a0313d575f
Autor:
Jenny Karlsson, Christoph A. Schatz, Antje M. Wengner, Stefanie Hammer, Arne Scholz, Alan Cuthbertson, Volker Wagner, Hartwig Hennekes, Vicki Jardine, Urs B. Hagemann
Publikováno v:
Frontiers in Medicine, Vol 9 (2023)
Targeted alpha therapy (TAT) is a promising approach for addressing unmet needs in oncology. Inherent properties make α-emitting radionuclides well suited to cancer therapy, including high linear energy transfer (LET), penetration range of 2–10 ce
Externí odkaz:
https://doaj.org/article/79d527281ca44a4b9b38e38914580781
Akademický článek
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Publikováno v:
EJNMMI Physics, Vol 8, Iss 1, Pp 1-16 (2021)
Abstract Background Actinium-225 is an alpha-particle emitter under investigation for use in radiopharmaceutical therapy. To address limited supply, accelerator-produced 225Ac has been recently made available. Accelerator-produced 225Ac via 232Th irr
Externí odkaz:
https://doaj.org/article/4be748613bc9471289128dc28816d5e9