Zobrazeno 1 - 10
of 249
pro vyhledávání: '"Alpha S. Yap"'
Autor:
Sharon Tran, Juliani Juliani, Tiffany J. Harris, Marco Evangelista, Julian Ratcliffe, Sarah L. Ellis, David Baloyan, Camilla M. Reehorst, Rebecca Nightingale, Ian Y. Luk, Laura J. Jenkins, Sonia Ghilas, Marina H. Yakou, Chantelle Inguanti, Chad Johnson, Michael Buchert, James C. Lee, Peter De Cruz, Kinga Duszyc, Paul A. Gleeson, Benjamin T. Kile, Lisa A. Mielke, Alpha S. Yap, John M. Mariadason, W. Douglas Fairlie, Erinna F. Lee
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Autophagy-related genes have been closely associated with intestinal homeostasis. BECLIN1 is a component of Class III phosphatidylinositol 3-kinase complexes that orchestrate autophagy initiation and endocytic trafficking. Here we show intes
Externí odkaz:
https://doaj.org/article/fc863b699bb647f5926120d1c9e15000
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102077- (2023)
Summary: Extracellular matrix (ECM) provides fundamental support for epithelial tissues and controls cell function. The chemistry and mechanical properties of ECM components, including stiffness, elasticity, and fibrillar organization, influence epit
Externí odkaz:
https://doaj.org/article/1d74e25da1f64ad0ada5619b32ea463e
Autor:
Kerrie-Ann McMahon, Yeping Wu, Yann Gambin, Emma Sierecki, Vikas A. Tillu, Thomas Hall, Nick Martel, Satomi Okano, Shayli Varasteh Moradi, Jayde E. Ruelcke, Charles Ferguson, Alpha S. Yap, Kirill Alexandrov, Michelle M. Hill, Robert G. Parton
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Caveolae are plasma membrane invaginations containing cavin proteins that are disrupted upon stress stimuli, causing cavin release inside the cell. Here, McMahon et al. identify cavin interacting proteins using proteomic analyses and reveal functions
Externí odkaz:
https://doaj.org/article/7e714ae10b044f39b3b19d07f1029486
Publikováno v:
STAR Protocols, Vol 1, Iss 2, Pp 100098- (2020)
Summary: Cellular traction forces influence epithelial behavior, including wound healing and cell extrusion. Here, we describe a simple in vitro traction force microscopy (TFM) protocol using ECM protein-coated polydimethylsiloxane substrate and wide
Externí odkaz:
https://doaj.org/article/0ff93303a89e48b1b35887668e803b70
Autor:
Anne Karine Lagendijk, Guillermo A. Gomez, Sungmin Baek, Daniel Hesselson, William E. Hughes, Scott Paterson, Daniel E. Conway, Heinz-Georg Belting, Markus Affolter, Kelly A. Smith, Martin A. Schwartz, Alpha S. Yap, Benjamin M. Hogan
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Mechanical forces play a crucial role during morphogenesis, but how these are sensed and transduced in vivo is not fully understood. Here the authors apply a FRET tension sensor to live zebrafish and study changes in VE-cadherin tension at endothelia
Externí odkaz:
https://doaj.org/article/05f4c034d6774bbe95030ef2e8d3c537
Autor:
Xuan Liang, Srikanth Budnar, Shafali Gupta, Suzie Verma, Siew-Ping Han, Michelle M. Hill, Roger J. Daly, Robert G. Parton, Nicholas A. Hamilton, Guillermo A. Gomez, Alpha S. Yap
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Epithelial cell-cell adhesions are contractile junctions, but whether contractility can be down-regulated is not known. Here the authors report how tyrosine dephosphorylation of the cytoskeletal scaffold, cortactin, recruits the RhoA antagonist SRGAP
Externí odkaz:
https://doaj.org/article/825f4db4af8b457a93e1d6628f784ef4
Autor:
Markus C. Kerr, Guillermo A. Gomez, Charles Ferguson, Maria C. Tanzer, James M. Murphy, Alpha S. Yap, Robert G. Parton, Wilhelmina M. Huston, Rohan D Teasdale
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Chlamydiae replicate in host cells within specialised vacuoles (inclusions), which are eventually ruptured to liberate the bacteria, leading to cell lysis. Here, Kerret al. use a laser ablation technique and videomicroscopy to show that inclusion rup
Externí odkaz:
https://doaj.org/article/5830fce444594ccebf7060c3ecb75ba5
Autor:
Bipul R. Acharya, Selwin K. Wu, Zi Zhao Lieu, Robert G. Parton, Stephan W. Grill, Alexander D. Bershadsky, Guillermo A. Gomez, Alpha S. Yap
Publikováno v:
Cell Reports, Vol 18, Iss 12, Pp 2854-2867 (2017)
Formins are a diverse class of actin regulators that influence filament dynamics and organization. Several formins have been identified at epithelial adherens junctions, but their functional impact remains incompletely understood. Here, we tested the
Externí odkaz:
https://doaj.org/article/78266f0bc89a48699a31cb4997d97b48
Autor:
Natalie K. Lee, Ka Wai Fok, Amanda White, Nicole H. Wilson, Conor J. O’Leary, Hayley L. Cox, Magdalene Michael, Alpha S. Yap, Helen M. Cooper
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The stability of epithelial adherens junctions depends on tension generated by actomyosin contractility. Here Lee et al. describe a novel role for the axon guidance receptor Neogenin in maintaining junctional stability by recruiting actin nucleation
Externí odkaz:
https://doaj.org/article/e78b4bf4b2f348dc937c00673a6a639b
Autor:
Katarzyna Koltowska, Anne Karine Lagendijk, Cathy Pichol-Thievend, Johanna C. Fischer, Mathias Francois, Elke A. Ober, Alpha S. Yap, Benjamin M. Hogan
Publikováno v:
Cell Reports, Vol 13, Iss 9, Pp 1828-1841 (2015)
Lymphatic vessels arise chiefly from preexisting embryonic veins. Genetic regulators of lymphatic fate are known, but how dynamic cellular changes contribute during the acquisition of lymphatic identity is not understood. We report the visualization
Externí odkaz:
https://doaj.org/article/0b38814fe9a54367aa6967152f15edac