Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Alpha Alex"'
Autor:
Eri Hashino, Alpha Alex, Jiyoon Lee, Kevin T. Booth, Adam A. Roth, Karl R. Koehler, Pei Ciao Tang, Jing Nie, Rick F. Nelson
Publikováno v:
Stem Cell Reports, Vol 13, Iss 1, Pp 147-162 (2019)
Stem Cell Reports
Stem Cell Reports
Summary Mutations in the gene encoding the type II transmembrane protease 3 (TMPRSS3) cause human hearing loss, although the underlying mechanisms that result in TMPRSS3-related hearing loss are still unclear. We combined the use of stem cell-derived
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Diabetic retinopathy (DR) is a leading cause of visual impairment. Muller cells in DR are dysfunctional due to downregulation of the inwardly rectifying potassium channel Kir4.1. Metformin, a commonly used oral antidiabetic drug, is known to
Automated computer-based enumeration of acellular capillaries for assessment of diabetic retinopathy
Publikováno v:
Medical Imaging: Biomedical Applications in Molecular, Structural, and Functional Imaging
Diabetic retinopathy (DR) is the most common complications of diabetes; if untreated the DR can lead to a vision loss. The treatment options for DR are limited and the development of newer therapies are of considerable interest. Drug screening for th
GENERATION OF MOSAIC STEM CELL DERIVED INNER EAR ORGANOIDS TO DETERMINE PARACRINE EFFECTS OF TMPRSS3
Publikováno v:
Proceedings of IMPRS. 2
Background and Hypothesis: The carefully timed treatment of mouse embryonic stem cell (mESC) cultures with small molecules results in mESC differentiation into 3D organoids containing all components of the inner ear such as hair cells (HCs), support
Autor:
Ashay D. Bhatwadekar, Maria B. Grant, Qianyi Luo, James M. Dominguez, Eleni Beli, Sergio Caballero, Jonathan Chen, Mark S. Segal, Alpha Alex, Tatiana E. Salazar, Julia V. Busik, Yanpeng Diao
Publikováno v:
The American Journal of Pathology. 187:1426-1435
The brain and muscle aryl hydrocarbon receptor nuclear translocator–like protein (BMAL)-1 constitutes a major transcriptional regulator of the circadian clock. Here, we explored the impact of conditional deletion of Bmal1 in endothelium and hematop
Publikováno v:
Diabetes. 68
Introduction: Diabetes is the leading cause of microvascular disorders such as diabetic retinopathy (DR). There are no treatments for DR and finding new drug targets is of considerable interest. SGLT2 inhibitors, a newer class of antidiabetics are pr
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Diabetes leads to the downregulation of the retinal Kir4.1 channels and Muller cell dysfunction. The insulin receptor substrate-1 (IRS-1) is a critical regulator of insulin signaling in Muller cells. Circadian rhythms play an integral role in