Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Alpeshkumar K. Malde"'
Autor:
Max T. B. Clabbers, Susannah Holmes, Timothy W. Muusse, Parimala R. Vajjhala, Sara J. Thygesen, Alpeshkumar K. Malde, Dominic J. B. Hunter, Tristan I. Croll, Leonie Flueckiger, Jeffrey D. Nanson, Md. Habibur Rahaman, Andrew Aquila, Mark S. Hunter, Mengning Liang, Chun Hong Yoon, Jingjing Zhao, Nadia A. Zatsepin, Brian Abbey, Emma Sierecki, Yann Gambin, Katryn J. Stacey, Connie Darmanin, Bostjan Kobe, Hongyi Xu, Thomas Ve
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
MAL and MyD88 are downstream adaptors of Toll-like receptors (TLR) and the MAL TIR domain forms filaments in vitro, which in turn nucleate the assembly of crystalline arrays of the MyD88 TIR domain. Here, the authors present the structure of these My
Externí odkaz:
https://doaj.org/article/5393cc79aa8d46d7b03a93a616d4e3b9
Autor:
Benjamin Bailly, Mark von Itzstein, Alpeshkumar K. Malde, Larissa Dirr, Susan J. Berners-Price, Anil K. Gorle, Nicholas Farrell
Publikováno v:
Chemical Communications. 57:4666-4669
We determine that the substitution-inert polynuclear platinum complex (PPC) TriplatinNC is an antiviral agent and protects cells from enterovirus 71 and human metapneumovirus infection. This protection occurs through the formation of adducts with cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f87474a990d3436a6c5dbb96546b995c
https://doi.org/10.1039/d1cc01593a
https://doi.org/10.1039/d1cc01593a
Autor:
Vivek Makwana, Alpeshkumar K. Malde, Shailendra Anoopkumar-Dukie, Santosh Rudrawar, Philip Ryan
Publikováno v:
ChemMedChem. 16:477-483
The O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) is a master regulator of installing O-GlcNAc onto serine or threonine residues on a multitude of target proteins. Numerous nuclear and cytosolic proteins of varying functional classes,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::753b2c3a044aa843e986d755ba4b4a44
https://doi.org/10.1002/cmdc.202000582
https://doi.org/10.1002/cmdc.202000582
Publikováno v:
Food Hydrocolloids. 133:108005
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f699464931be600bf01eaba397aa04f
https://doi.org/10.1016/j.foodhyd.2022.108005
https://doi.org/10.1016/j.foodhyd.2022.108005
Publikováno v:
Biomacromolecules. 22(11)
Granule-bound starch synthase (GBSS) plays a major role, that of chain elongation, in the biosynthesis of amylose, a starch component with mostly (1 → 4)-α connected long chains of glucose with a few (1 → 6)-α branch points. Chain-length distri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa08f71ed745c89f61902778e21c5ef
https://pubmed.ncbi.nlm.nih.gov/34669391
https://pubmed.ncbi.nlm.nih.gov/34669391
Autor:
Cheng Li, Alex Chi Wu, Rob Marc Go, Jacob Malouf, Mark S Turner, Alpeshkumar K Malde, Alan E Mark, Robert G Gilbert
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0125507 (2015)
Starch is a complex branched glucose polymer whose branch molecular weight distribution (the chain-length distribution, CLD) influences nutritionally important properties such as digestion rate. Chain-stopping in starch biosynthesis is by starch bran
Externí odkaz:
https://doaj.org/article/70db23f0bdcc4bbeabab818d5ea4f3d5
Autor:
Andrew Aquila, Emma Sierecki, Chun Hong Yoon, Jingjing Zhao, Connie Darmanin, Tristan I. Croll, Md. Habibur Rahaman, Yann Gambin, Alpeshkumar K. Malde, Timothy W. Muusse, Parimala R. Vajjhala, Hongyi Xu, Max T. B. Clabbers, Sara J. Thygesen, Leonie Flueckiger, Mark S. Hunter, Brian Abbey, Bostjan Kobe, Nadia A. Zatsepin, Jeffrey D. Nanson, Katryn J. Stacey, Thomas Ve, Dominic J. B. Hunter, Susannah Holmes, Mengning Liang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications 12(1), 2578 (2021). doi:10.1038/s41467-021-22590-6
Nature Communications
Nature Communications 12(1), 2578 (2021). doi:10.1038/s41467-021-22590-6
MyD88 and MAL are Toll-like receptor (TLR) adaptors that signal to induce pro-inflammatory cytokine production. We previously observed that the TIR domain of MAL (MALTIR) forms filaments in vitro and induces formation of crystalline higher-order asse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de89df648be80cc1ecc2cd07ba2b8bad
Autor:
Matthew D, Figley, Weixi, Gu, Jeffrey D, Nanson, Yun, Shi, Yo, Sasaki, Katie, Cunnea, Alpeshkumar K, Malde, Xinying, Jia, Zhenyao, Luo, Forhad K, Saikot, Tamim, Mosaiab, Veronika, Masic, Stephanie, Holt, Lauren, Hartley-Tassell, Helen Y, McGuinness, Mohammad K, Manik, Todd, Bosanac, Michael J, Landsberg, Philip S, Kerry, Mehdi, Mobli, Robert O, Hughes, Jeffrey, Milbrandt, Bostjan, Kobe, Aaron, DiAntonio, Thomas, Ve
Publikováno v:
Neuron. 109(7)
Axon degeneration is a central pathological feature of many neurodegenerative diseases. Sterile alpha and Toll/interleukin-1 receptor motif-containing 1 (SARM1) is a nicotinamide adenine dinucleotide (NAD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::850dd49db6faec49e9f5dd7ffea7ec3f
https://pubmed.ncbi.nlm.nih.gov/33831359
https://pubmed.ncbi.nlm.nih.gov/33831359
Publikováno v:
Malde, A K, Stroet, M, Caron, B, Visscher, K M & Mark, A E 2018, ' Predicting the Prevalence of Alternative Warfarin Tautomers in Solution ', Journal of Chemical Theory and Computation, vol. 14, no. 8, pp. 4405-4415 . https://doi.org/10.1021/acs.jctc.8b00453
Journal of Chemical Theory and Computation, 14(8), 4405-4415. American Chemical Society
Journal of Chemical Theory and Computation, 14(8), 4405-4415. American Chemical Society
Warfarin, a widely used oral anticoagulant, is prescribed as a racemic mixture. Each enantiomer of neutral Warfarin can exist in 20 possible tautomeric states leading to complex pharmacokinetics and uncertainty as to the relevant species under differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db04a1478a8663b6c0dc0b1dd9d8c103
https://doi.org/10.1021/acs.jctc.8b00453
https://doi.org/10.1021/acs.jctc.8b00453