Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Alpesh Thakker"'
Autor:
Dunja Aksentijević, Anja Karlstaedt, Marina V. Basalay, Brett A. O’Brien, David Sanchez-Tatay, Seda Eminaga, Alpesh Thakker, Daniel A. Tennant, William Fuller, Thomas R. Eykyn, Heinrich Taegtmeyer, Michael J. Shattock
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The failing heart is characterised by both alterations in mitochondrial metabolism and an elevation of cytosolic sodium. Here, the authors use 23Na NMR and metabolic profiling to show these are related, and that elevation in intracellular Na reprogra
Externí odkaz:
https://doaj.org/article/01651cc80f9b4aad9898d7152d51f740
Autor:
Daniela Nasteska, Federica Cuozzo, Katrina Viloria, Elspeth M. Johnson, Alpesh Thakker, Rula Bany Bakar, Rebecca L. Westbrook, Jonathan P. Barlow, Monica Hoang, Jamie W. Joseph, Gareth G. Lavery, Ildem Akerman, James Cantley, Leanne Hodson, Daniel A. Tennant, David J. Hodson
Publikováno v:
JCI Insight, Vol 6, Iss 16 (2021)
The α-ketoglutarate–dependent dioxygenase, prolyl-4-hydroxylase 3 (PHD3), is an HIF target that uses molecular oxygen to hydroxylate peptidyl prolyl residues. Although PHD3 has been reported to influence cancer cell metabolism and liver insulin se
Externí odkaz:
https://doaj.org/article/1bf081e6aea049debb7985fde804b9c9
Autor:
Matthew C. Sinton, Jose Meseguer-Ripolles, Baltasar Lucendo-Villarin, Sara Wernig-Zorc, John P. Thomson, Roderick N. Carter, Marcus J. Lyall, Paul D. Walker, Alpesh Thakker, Richard R. Meehan, Gareth G. Lavery, Nicholas M. Morton, Christian Ludwig, Daniel A. Tennant, David C. Hay, Amanda J. Drake
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101931- (2021)
Summary: Nonalcoholic fatty liver disease (NAFLD) is currently the most prevalent form of liver disease worldwide. This term encompasses a spectrum of pathologies, from benign hepatic steatosis to non-alcoholic steatohepatitis, which have, to date, b
Externí odkaz:
https://doaj.org/article/231ee5e1aa334f8c91d6ea963c63a1fc
Autor:
Kate E.R. Hollinshead, Haydn Munford, Katherine L. Eales, Chiara Bardella, Chunjie Li, Cristina Escribano-Gonzalez, Alpesh Thakker, Yannic Nonnenmacher, Katarina Kluckova, Mark Jeeves, Robert Murren, Federica Cuozzo, Dan Ye, Giulio Laurenti, Wei Zhu, Karsten Hiller, David J. Hodson, Wei Hua, Ian P. Tomlinson, Christian Ludwig, Ying Mao, Daniel A. Tennant
Publikováno v:
Cell Reports, Vol 22, Iss 12, Pp 3107-3114 (2018)
Summary: Since the discovery of mutations in isocitrate dehydrogenase 1 (IDH1) in gliomas and other tumors, significant efforts have been made to gain a deeper understanding of the consequences of this oncogenic mutation. One aspect of the neomorphic
Externí odkaz:
https://doaj.org/article/26706adfa2534c22a56f1079550fabca
Autor:
Lucy A. Oakey, Rachel S. Fletcher, Yasir S. Elhassan, David M. Cartwright, Craig L. Doig, Antje Garten, Alpesh Thakker, Oliver D. K. Maddocks, Tong Zhang, Daniel A. Tennant, Christian Ludwig, Gareth G. Lavery
Publikováno v:
Wellcome Open Research, Vol 3 (2019)
Background: Skeletal muscle is central to whole body metabolic homeostasis, with age and disease impairing its ability to function appropriately to maintain health. Inadequate NAD+ availability is proposed to contribute to pathophysiology by impairin
Externí odkaz:
https://doaj.org/article/549dd6578fc74f51bc326169ecd9dbcd
Autor:
Judith Favier, Daniel A. Tennant, Eric Letouzé, Anne-Paule Gimenez-Roqueplo, Fatima Mechta-Grigoriou, Raphaël Rodriguez, Jennie Roberts, Lisa Vettore, Alpesh Thakker, Paule Bénit, Charlotte Lussey-Lepoutre, Cynthia L. Andoniadou, Theodora J. Stewart, Katarina Kluckova, Alexander P. Morrell, Sebastian Müller, Géraldine Gentric, Aurélie Morin, Sophie Moog, Judith Goncalves
Succinate dehydrogenase is a key enzyme in the tricarboxylic acid cycle and the electron transport chain. All four subunits of succinate dehydrogenase are tumor suppressor genes predisposing to paraganglioma, but only mutations in the SDHB subunit ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8344fed531abd70c4e2067dd3f8dac8
https://doi.org/10.1158/0008-5472.c.6513153.v1
https://doi.org/10.1158/0008-5472.c.6513153.v1
Autor:
Judith Favier, Daniel A. Tennant, Eric Letouzé, Anne-Paule Gimenez-Roqueplo, Fatima Mechta-Grigoriou, Raphaël Rodriguez, Jennie Roberts, Lisa Vettore, Alpesh Thakker, Paule Bénit, Charlotte Lussey-Lepoutre, Cynthia L. Andoniadou, Theodora J. Stewart, Katarina Kluckova, Alexander P. Morrell, Sebastian Müller, Géraldine Gentric, Aurélie Morin, Sophie Moog, Judith Goncalves
Supplementary Figure 1 - Supplementary Figure 2 - Supplementary Figure 3 - Supplementary Figure 4 - Supplementary Figure 5 - Supplementary Figure 6 - Supplementary Table 1 - Supplementary Table 2 - Supplementary Table 3 - Supplementary Table 4 - Supp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14fa5c66a17bcd42509bb7c99b59f814
https://doi.org/10.1158/0008-5472.22428819
https://doi.org/10.1158/0008-5472.22428819
Autor:
Judith Favier, Daniel A. Tennant, Eric Letouzé, Anne-Paule Gimenez-Roqueplo, Fatima Mechta-Grigoriou, Raphaël Rodriguez, Jennie Roberts, Lisa Vettore, Alpesh Thakker, Paule Bénit, Charlotte Lussey-Lepoutre, Cynthia L. Andoniadou, Theodora J. Stewart, Katarina Kluckova, Alexander P. Morrell, Sebastian Müller, Géraldine Gentric, Aurélie Morin, Sophie Moog, Judith Goncalves
Supplementary Table 2 Related to Figure 2. Differentially methylated gene-based features in Sdhb-/- versus Sdhd-/- imCCs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b04c08f42c8e0660b2c6f91c099c84
https://doi.org/10.1158/0008-5472.22428816.v1
https://doi.org/10.1158/0008-5472.22428816.v1
Autor:
Heinrich Taegtmeyer, Seda Eminaga, David Sanchez-Tatay, William Fuller, Michael J. Shattock, Thomas R. Eykyn, Dunja Aksentijevic, Marina Basalay, Alpesh Thakker, Anja Karlstaedt, Brett A. O’Brien, Daniel A. Tennant
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Aksentijević, D, Karlstaedt, A, Basalay, M V, O'Brien, B A, Sanchez-Tatay, D, Eminaga, S, Thakker, A, Tennant, D A, Fuller, W, Eykyn, T R, Taegtmeyer, H & Shattock, M 2020, ' Intracellular sodium elevation reprograms cardiac metabolism ', Nature Communications, vol. 11, no. 1, 4337 . https://doi.org/10.1038/s41467-020-18160-x
Nature Communications
Aksentijević, D, Karlstaedt, A, Basalay, M V, O'Brien, B A, Sanchez-Tatay, D, Eminaga, S, Thakker, A, Tennant, D A, Fuller, W, Eykyn, T R, Taegtmeyer, H & Shattock, M 2020, ' Intracellular sodium elevation reprograms cardiac metabolism ', Nature Communications, vol. 11, no. 1, 4337 . https://doi.org/10.1038/s41467-020-18160-x
Intracellular Na elevation in the heart is a hallmark of pathologies where both acute and chronic metabolic remodelling occurs. Here, we assess whether acute (75 μM ouabain 100 nM blebbistatin) or chronic myocardial Nai load (PLM3SA mouse) are causa
Autor:
Rebecca L. Hindshaw, Gareth G. Lavery, Baksho Kaul, Judith Goncalves, Cristina Escribano-Gonzalez, Katarína Kľučková, Lisa Vettore, Alpesh Thakker, Judith Favier, Daniel A. Tennant, Jacqueline L. E. Tearle
Publikováno v:
The FASEB Journal. 34:303-315
Mutations in succinate dehydrogenase (SDH) lead to the development of tumors in a restricted subset of cell types, including chromaffin cells and paraganglia. The molecular basis for this specificity is currently unknown. We show that loss of SDH act