Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Alpesh Ramanlal Patel"'
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 71, Iss 11, Pp 1361-1365 (2015)
The structure of the title compound, C15H16F6N4O3, was determined using synchrotron radiation on an extremely small crystal (0.015 × 0.01 × 0.01 mm). Although the diffraction was weak, leading to high residuals and a poor data-to-parameter ratio, t
Externí odkaz:
https://doaj.org/article/c42d4588be9e41a2aac3dfda35c84a62
Publikováno v:
Tetrahedron. 73:6401-6409
An aryl-bridged dixanthene scaffold is quickly prepared and readily derivatized with functional groups at the four 4,5-positions adjacent to the oxygen atoms of the two xanthene groups: syntheses of five potentially tetradentate, multinucleating, met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::222ee2bd282e895a0255e77d6cc6ef32
https://doi.org/10.1016/j.tet.2017.09.026
https://doi.org/10.1016/j.tet.2017.09.026
Publikováno v:
Journal of Chemical Education. 94:1107-1110
A laboratory experiment to determine the concentration of the anti-inflammatory drug ibuprofen in liquid gelatin capsule dosage forms, suitable for undergraduate chemistry or pharmacy students, is described. Either individually, or in small teams, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23915aeb19bdec94fa88d8d534ffc782
https://doi.org/10.1021/acs.jchemed.6b00955
https://doi.org/10.1021/acs.jchemed.6b00955
Publikováno v:
Organic & Biomolecular Chemistry. 15:1570-1574
Acquiring a divergent response from homologous protein domains is essential for selective ligand-protein interactions. Stereospecific fluorination of (-)-balanol, an ATP mimic, uncovers a new source of selectivity from integrated chemical and conform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f50d849b17d77dc2b0ac0cc495e9204
https://doi.org/10.1039/c7ob00129k
https://doi.org/10.1039/c7ob00129k
Autor:
Johny Trinh, Alpesh Ramanlal Patel, Md. Iqbal Ahmed, Aggie Lawer, Xiang-Guo Hu, Elizabeth Hannah, Catherine Au, Luke Hunter, Christina Gonzalez, Mohan M. Bhadbhade, Rasha Saad Jwad
Publikováno v:
Tetrahedron. 72:3305-3317
Backbone-fluorinated gamma-amino acids are novel shape-controlled building blocks that have potential utility in a variety of biological contexts. However, their synthesis poses challenges in terms of chemo-, regio- and stereoselectivity, and this ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4caa037d73f479011b49f88a15dc567e
https://doi.org/10.1016/j.tet.2016.04.070
https://doi.org/10.1016/j.tet.2016.04.070
Publikováno v:
European Journal of Organic Chemistry. 2014:2584-2593
Substituted azepanes have flexible ring structures and this conformational diversity is important for their bioactivity. We have shown that a single fluorine atom, when installed diastereoselectively on a model azepane ring, can bias its ring to one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0efa013c7016af552e510a495d4cdd9e
https://doi.org/10.1002/ejoc.201301811
https://doi.org/10.1002/ejoc.201301811
Autor:
Fei Liu, Alpesh Ramanlal Patel
Publikováno v:
Tetrahedron. 69:744-752
Fluorination of bioactive compounds is an important step in drug discovery and development. Fluorination has been extensively studied in acyclic systems, carbocycles, and fused heterocycles. However, there is no report on fluorination of azepanes. As
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::535bb4b603310ce81406b81560990557
https://doi.org/10.1016/j.tet.2012.10.078
https://doi.org/10.1016/j.tet.2012.10.078
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications
Acta Crystallographica Section E: Crystallographic Communications, Vol 71, Iss 11, Pp 1361-1365 (2015)
Acta Crystallographica Section E: Crystallographic Communications, Vol 71, Iss 11, Pp 1361-1365 (2015)
This report describes the crystal structure of highly substituted trifluoroazepane as an important building block of therapeutic interest. Data were collected with synchrotron radiation on a very small crystal.
The structure of the title c
The structure of the title c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a46c2f1f6d1e9e02a27b2477cba860ab
https://pubmed.ncbi.nlm.nih.gov/26594511
https://pubmed.ncbi.nlm.nih.gov/26594511
Autor:
Alpesh Ramanlal Patel, Fei Liu
Publikováno v:
Australian Journal of Chemistry. 68:50
Seven-membered N-heterocycles are flexible ring structures, and their conformational control is important to their bioactivity. Our prior work shows that stereoselective monofluorination, if installed diastereoselectively, can bias a seven-membered,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18180d81cfea75893a6df60b76044ba1
https://doi.org/10.1071/ch14256
https://doi.org/10.1071/ch14256
Publikováno v:
Organic & Biomolecular Chemistry. 11:3781
Substituted azepanes are common bioactive epitopes with flexible ring structures. The conformational effects of monofluorination in model azepane rings were investigated by (1)H NMR spectroscopy and computational modelling. A single fluorine atom, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276bd8927c1d1132312be8c3152cb06c
https://doi.org/10.1039/c3ob40391b
https://doi.org/10.1039/c3ob40391b