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p19ARF is a critical mediator of both cellular senescence and an innate immune response associated with MYC inactivation in mouse model of acute leukemia

Autor: Alper Yetil, Arvin M. Gouw, Benedict Anchang, Ramya Parameswaran, Stacey J. Adam, Dean W. Felsher, Sylvia K. Plevritis, Jan van Riggelen, Tahera Zabuawala

Publikováno v: Oncotarget

MYC-induced T-ALL exhibit oncogene addiction. Addiction to MYC is a consequence of both cell-autonomous mechanisms, such as proliferative arrest, cellular senescence, and apoptosis, as well as non-cell autonomous mechanisms, such as shutdown of angio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fac15227cfbc7d1543f8fdda15766f03
http://europepmc.org/articles/PMC4414137

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The interaction between Myc and Miz1 is required to antagonize TGFβ-dependent autocrine signaling during lymphoma formation and maintenance

Autor: Martin Eilers, Tarik Möröy, Vincent Beuger, Christian Kosan, Peter S. Choi, Dean W. Felsher, Tobias Otto, Jan van Riggelen, Judith Müller, Alper Yetil

Publikováno v: Genes & Development. 24:1281-1294

The Myc protein suppresses the transcription of several cyclin-dependent kinase inhibitors (CKIs) via binding to Miz1; whether this interaction is important for Myc's ability to induce or maintain tumorigenesis is not known. Here we show that the onc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fda2589254a0b83f986392f42ec197d
https://doi.org/10.1101/gad.585710

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Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation

Autor: Chi Hwa Wu, Alper Yetil, Alice C. Fan, Dean W. Felsher, Jan van Riggelen, Pavan Bachireddy

Publikováno v: Proceedings of the National Academy of Sciences. 104:13028-13033

Oncogene-induced senescence is an important mechanism by which normal cells are restrained from malignant transformation. Here we report that the suppression of the c-Myc (MYC) oncogene induces cellular senescence in diverse tumor types including lym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d553be764f724af206baf8e573cc1f1a
https://doi.org/10.1073/pnas.0701953104

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Resistance to Antiangiogenic Therapy Is Associated with an Immunosuppressive Tumor Microenvironment in Metastatic Renal Cell Carcinoma

Publikováno v: Cancer Immunology Research, 3(9), 1017-1029. American Association for Cancer Research Inc.
Liu, X D, Hoang, A, Zhou, L J, Kalra, S, Yetil, A, Sun, M N, Ding, Z Y, Zhang, X S, Bai, S S, German, P, Tamboli, P, Rao, P, Karam, J A, Wood, C, Matin, S, Zurita, A, Bex, A, Griffioen, A W, Gao, J J, Sharma, P, Tannir, N, Sircar, K & Jonasch, E 2015, ' Resistance to Antiangiogenic Therapy Is Associated with an Immunosuppressive Tumor Microenvironment in Metastatic Renal Cell Carcinoma ', Cancer Immunology Research, vol. 3, no. 9, pp. 1017-1029 . https://doi.org/10.1158/2326-6066.CIR-14-0244

Renal cell carcinoma (RCC) is an immunogenic and proangiogenic cancer, and antiangiogenic therapy is the current mainstay of treatment. Patients with RCC develop innate or adaptive resistance to antiangiogenic therapy. There is a need to identify bio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4f439ab15a080e8b9ff77de8add8cdf
https://research.vumc.nl/en/publications/5178595e-67cb-45e5-8e96-36e9fd331496

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Characterization of a synthetic human LINE-1 retrotransposon ORFeus-Hs

Autor: Lixin Dai, Jef D. Boeke, Anna Maria Niewiadomska, Wenfeng An, Alper Yetil, Kathryn A. O'Donnell, Jeffrey S. Han

Publikováno v: Mobile DNA
Mobile DNA, Vol 2, Iss 1, p 2 (2011)

Long interspersed elements, type 1(LINE-1, L1) are the most abundant and only active autonomous retrotransposons in the human genome. Native L1 elements are inefficiently expressed because of a transcription elongation defect thought to be caused by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3a5c370e78f16699343008181d9ddcf
https://doi.org/10.1186/1759-8753-2-2

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MYC as a regulator of ribosome biogenesis and protein synthesis

Autor: Jan van Riggelen, Dean W. Felsher, Alper Yetil

Publikováno v: Nature reviews. Cancer. 10(4)

Recently, MYC has been shown to serve as a direct regulator of ribosome biogenesis and therefore coordinates protein synthesis. Could the regulation of ribosome biogenesis by MYC be necessary for its role in tumorigenesis? MYC regulates the transcrip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a4a01ce96b103f784f25c4dc3804bb5
https://pubmed.ncbi.nlm.nih.gov/20332779

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Association of resistance to antiangiogenic therapy with an immunosuppressive tumor microenvironment in metastatic renal cell carcinoma

Publikováno v: Journal of Clinical Oncology. 33:419-419

419 Background: Renal cell carcinoma (RCC) is an immunogenic and proangiogenic cancer, and anti-angiogenic therapy is the current mainstay of treatment. RCC patients develop innate or adaptive resistance to anti-angiogenic therapy. There is a need to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f471debf6c7f4fa30ae0940a9ec4104d
https://doi.org/10.1200/jco.2015.33.7_suppl.419

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Abstract 29: Myeloid cell and plasma cytokine and angiogenic factor (CAF) dynamics in association with response to VEGFR inhibitors cediranib and sunitinib

Autor: Amado J. Zurita, John V. Heymach, Alper Yetil

Publikováno v: Cancer Research. 74:29-29

Background: Anti-angiogenic agents targeting the VEGF pathway have improved the outcomes of patients with metastatic renal cell carcinoma (mRCC), but therapy resistance consistently occurs. In RCC, the presence of increased intratumoral and periphera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a5a706401f35a47c7bcd60cfcc2e5239
https://doi.org/10.1158/1538-7445.am2014-29

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