Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Alparslan Asan"'
Autor:
Lisa Hong, Dennis C. Braden, Yaoning Zhao, John J. Skoko, Fei Chang, Steven R. Woodcock, Crystall Uvalle, Allison Casey, Katherine Wood, Sonia R. Salvatore, Alparslan Asan, Trey Harkness, Adeola Fagunloye, Mortezaali Razzaghi, Adam Straub, Maria Spies, Daniel D. Brown, Adrian V. Lee, Francisco Schopfer, Bruce A. Freeman, Carola A. Neumann
Publikováno v:
Redox Biology, Vol 66, Iss , Pp 102856- (2023)
Nitro fatty acids (NO2-FAs) are endogenously generated lipid signaling mediators from metabolic and inflammatory reactions between conjugated diene fatty acids and nitric oxide or nitrite-derived reactive species. NO2-FAs undergo reversible Michael a
Externí odkaz:
https://doaj.org/article/74e2d4a459964b33908f0fc33cbe7493
Autor:
John J. Skoko, Juxiang Cao, David Gaboriau, Myriam Attar, Alparslan Asan, Lisa Hong, Candice E. Paulsen, Hongqiang Ma, Yang Liu, Hanzhi Wu, Trey Harkness, Cristina M. Furdui, Yefim Manevich, Ciaran G. Morrison, Erika T. Brown, Daniel Normolle, Maria Spies, Michael Ashley Spies, Kate Carroll, Carola A. Neumann
Publikováno v:
Redox Biology, Vol 56, Iss , Pp 102443- (2022)
RAD51 is a critical recombinase that functions in concert with auxiliary mediator proteins to direct the homologous recombination (HR) DNA repair pathway. We show that Cys319 RAD51 possesses nucleophilic characteristics and is important for irradiati
Externí odkaz:
https://doaj.org/article/2fc66d80d6fa4b56ae9f41a240a26b8a
Publikováno v:
PLoS Genetics, Vol 12, Iss 5, p e1006077 (2016)
[This corrects the article DOI: 10.1371/journal.pgen.1005950.].
Externí odkaz:
https://doaj.org/article/49d4eec3304f416cbf90623a29fe6ac3
Autor:
Balakrishnan Ganapathy, Nikitha Nandhagopal, Brian D Polizzotti, David Bennett, Alparslan Asan, Yijen Wu, Bernhard Kühn
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155456 (2016)
BACKGROUND:We previously developed and validated a strategy for stimulating heart regeneration by administration of recombinant neuregulin (rNRG1), a growth factor, in mice. rNRG1 stimulated proliferation of heart muscle cells, cardiomyocytes, and wa
Externí odkaz:
https://doaj.org/article/5c29601be6df4c94a87b315224a8e42b
Autor:
Megan K. Wright, Shireen Attaran, Carola A. Neumann, Barbara L. Hopkins, Laurel E. Wood, Hyun Ae Woo, John J. Skoko, Adam W. Feinberg, Alparslan Asan
Publikováno v:
Br J Cancer
BACKGROUND: Peroxiredoxin 1 (PRDX1) belongs to an abundant family of peroxidases whose role in cancer is still unresolved. While mouse knockout studies demonstrate a tumour suppressive role for PRDX1, in cancer cell xenografts, results denote PRDX1 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb4dcc97de5e5c5911b75e9877bba6d9
https://europepmc.org/articles/PMC8505437/
https://europepmc.org/articles/PMC8505437/
Autor:
Bentley M. Wingert, Chen-Shan Chen Woodcock, Yi Huang, Jeremy M. Stark, Daniel P. Normolle, Carlos J. Camacho, Alparslan Asan, Carola A. Neumann, Bruce A. Freeman, John J. Skoko, Steven R. Woodcock
Publikováno v:
Journal of Biological Chemistry. 294:397-404
Homologous recombination (HR)-directed DNA double-strand break (DSB) repair enables template-directed DNA repair to maintain genomic stability. RAD51 recombinase (RAD51) is a critical component of HR and facilitates DNA strand exchange in DSB repair.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fdcce77e8392faffcd94a445fe25f16
https://doi.org/10.1074/jbc.ac118.005899
https://doi.org/10.1074/jbc.ac118.005899
Autor:
David C. A. Gaboriau, Steven R. Woodcock, Carola A. Neumann, Erika T. Brown, Yefim Manevich, Ciaran G. Morrison, Yang Liu, Hongqiang Ma, Alparslan Asan, Bentley M. Wingert, Juxiang Cao, Kate S. Carroll, Myriam A. Attar, Carlos J. Camacho, John J. Skoko, Candice E. Paulsen, Chen Shan C. Woodcock, Bruce A. Freeman, Jennifer Schulte
Publikováno v:
SSRN Electronic Journal.
Peroxiredoxin 1 (PRDX1) senses and reduces peroxides and coordinates the signaling actions of its binding partners. We show that PRDX1 protects RAD51 from oxidation-induced repression of homologous recombination (HR) repair following ɣ-irradiation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fab5ca4e38b2f9d3306deac0bcfc0207
https://doi.org/10.2139/ssrn.3155568
https://doi.org/10.2139/ssrn.3155568
Publikováno v:
PLoS Genetics, Vol 12, Iss 5, p e1006077 (2016)
[This corrects the article DOI: 10.1371/journal.pgen.1005950.].
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff9c4b26421e1d68ef0adbd8a8959c3b
http://europepmc.org/articles/PMC4871574?pdf=render
http://europepmc.org/articles/PMC4871574?pdf=render
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 12, Iss 4, p e1005950 (2016)
PLoS Genetics, Vol 12, Iss 4, p e1005950 (2016)
Genetic and molecular studies have provided considerable insight into how various tissue progenitors are specified in early embryogenesis, but much less is known about how those progenitors create three-dimensional tissues and organs. The C. elegans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3715bb52c78870e2c11bbbd6fdc33d6a
http://europepmc.org/articles/PMC4817974
http://europepmc.org/articles/PMC4817974
Autor:
Jennifer Schulte, Hongqiang Ma, Kate S. Carroll, Candice E. Paulsen, Chen-Shan Chen Woodcock, John J. Skoko, Bruce A. Freeman, Steven R. Woodcock, Bentley M. Wingert, David C. A. Gaboriau, Juxiang Cao, Myriam A. Attar, Carlos J. Camacho, Ciaran G. Morrison, Yang Liu, Carola A. Neumann, Alparslan Asan
Publikováno v:
Free Radical Biology and Medicine. 112:100-101
Peroxiredoxin 1 (PRDX1) senses and reduces peroxides and coordinates the signaling actions of its binding partners. Loss of Prdx1 function in mice has been shown to enhance susceptibility to various cancers, including breast cancer. Homologous recomb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0c5ce6f5a8f476fb8e4c38a2409f052
https://doi.org/10.1016/j.freeradbiomed.2017.10.151
https://doi.org/10.1016/j.freeradbiomed.2017.10.151