Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Aloysius T. Nchinda"'
Autor:
Rudolf Mueller, Virsinha Reddy, Aloysius T. Nchinda, Fanuel Mebrahtu, Dale Taylor, Nina Lawrence, Lloyd Tanner, Marine Barnabe, Charles J. Eyermann, Bin Zou, Ravinder R. Kondreddi, Suresh B. Lakshminarayana, Matthias Rottmann, Leslie J. Street, Kelly Chibale
Publikováno v:
ACS Omega, Vol 5, Iss 12, Pp 6967-6982 (2020)
Externí odkaz:
https://doaj.org/article/4ad36f674d374ec382c3bc8f6343258f
Autor:
Stephen Fienberg, Gregory S. Basarab, Anne J. Lenaerts, Virsinha Reddy, Sandeep R. Ghorpade, Mathew Njoroge, Grant A. Boyle, Charles J. Eyermann, Clifton E. Barry, Timothy G. Myers, Efrem Abay, Nina Lawrence, Alissa Myrick, Helena I. Boshoff, Vinayak Singh, Lutete Peguy Khonde, Lisa M. Massoudi, Paul D. van Helden, Frederick A. Sirgel, Gregory T. Robertson, Rudolf Müller, Kelly Chibale, Aloysius T. Nchinda, Qin Su
Publikováno v:
Journal of Medicinal Chemistry. 64:12790-12807
Phenotypic whole cell high-throughput screening of a ∼150,000 diverse set of compounds against Mycobacterium tuberculosis (Mtb) in cholesterol-containing media identified 1,3-diarylpyrazolyl-acylsulfonamide 1 as a moderately active hit. Structure-a
Autor:
Anthony J. Smith, Dale Taylor, Anne J. Lenaerts, Thomas R. Ioerger, Nina Lawrence, Kelly Chibale, Rudolf Mueller, Vinayak Singh, Claire Le Manach, Aloysius T. Nchinda, Alissa Myrick, Mathew Njoroge, Paul M. Njaria, Elizabeth J. Brooks, Atica Moosa, Jessica N. Akester, Gregory T. Robertson
Publikováno v:
ACS Infectious Diseases
Phenotypic whole-cell screening against Mycobacterium tuberculosis (Mtb) in glycerol-alanine-salts supplemented with Tween 80 and iron (GASTE-Fe) media led to the identification of a 2-aminoquinazolinone hit compound, sulfone 1 which was optimized fo
Autor:
Lutete Peguy, Khonde, Rudolf, Müller, Grant A, Boyle, Virsinha, Reddy, Aloysius T, Nchinda, Charles J, Eyermann, Stephen, Fienberg, Vinayak, Singh, Alissa, Myrick, Efrem, Abay, Mathew, Njoroge, Nina, Lawrence, Qin, Su, Timothy G, Myers, Helena I M, Boshoff, Clifton E, Barry, Frederick A, Sirgel, Paul D, van Helden, Lisa M, Massoudi, Gregory T, Robertson, Anne J, Lenaerts, Gregory S, Basarab, Sandeep R, Ghorpade, Kelly, Chibale
Publikováno v:
Journal of medicinal chemistry. 64(17)
Phenotypic whole cell high-throughput screening of a ∼150,000 diverse set of compounds against
Autor:
Jean Dam, Keletso Maepa, Lutete Peguy Khonde, Claire Le Manach, Janette Reader, Mariëtte van der Watt, Gregory S. Basarab, Sergio Wittlin, John Okombo, Kathryn J. Wicht, James Duffy, Aloysius T. Nchinda, Dale Taylor, André Horatscheck, Mathew Njoroge, Christel Brunschwig, Timothy J. Egan, Nina Lawrence, Ana Carolina C. de Sousa, Leslie J. Street, Kelly Chibale, Lyn-Marie Birkholtz, Ana Andrijevic, Liezl Gibhard, Tanya Paquet, Kailash P. Pawar, Paul V. Fish
Publikováno v:
J Med Chem
A series of 2,4-disubstituted imidazopyridines, originating from a SoftFocus Kinase library, was identified from a high throughput phenotypic screen against the human malaria parasite Plasmodium falciparum. Hit compounds showed moderate asexual blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0f65b29b16b46e7c416d1fc66f6377
https://europepmc.org/articles/PMC7756195/
https://europepmc.org/articles/PMC7756195/
Autor:
Fanuel Mebrahtu, Leslie J. Street, Marine Barnabe, Rudolf Mueller, Nina Lawrence, Matthias Rottmann, Virsinha Reddy, Aloysius T. Nchinda, Ravinder Reddy Kondreddi, Dale Taylor, Lloyd Tanner, Charles J. Eyermann, Kelly Chibale, Suresh B. Lakshminarayana, Bin Zou
Publikováno v:
ACS Omega
ACS Omega, Vol 5, Iss 12, Pp 6967-6982 (2020)
ACS Omega, Vol 5, Iss 12, Pp 6967-6982 (2020)
A phenotypic whole cell high-throughput screen against the asexual blood and liver stages of the malaria parasite identified a benzimidazole chemical series. Among the hits were the antiemetic benzimidazole drug Lerisetron 1 (IC50 NF54 = 0.81 μM) an
Autor:
Claire Le Manach, Dale Taylor, Diego Gonzàlez Cabrera, James Duffy, Nina Lawrence, Santiago Ferrer, Kelly Chibale, Mathew Njoroge, Christel Brunschwig, Efrem Abay, Iñigo Angulo-Barturen, María-Belén Jiménez-Díaz, María Santos Martínez, Jeremy N. Burrows, Sergio Wittlin, Kathryn J. Wicht, Aloysius T. Nchinda, Tanya Paquet, Maria Jose Lafuente-Monasterio, Leslie J. Street
Publikováno v:
Journal of Medicinal Chemistry. 61:4213-4227
Optimization of a chemical series originating from whole-cell phenotypic screening against the human malaria parasite, Plasmodium falciparum, led to the identification of two promising 2,6-disubstituted imidazopyridine compounds, 43 and 74. These com
Autor:
Tanya Paquet, David A. Fidock, Efrem Abay, Iñigo Angulo-Barturen, Kigbafori D. Silué, Diego Gonzàlez Cabrera, Mathew Njoroge, Leslie J. Street, Rintis Noviyanti, Karen L. White, Grennady Wirjanata, Cristina Donini, Michael J Witty, Nina Lawrence, Dalu Mancama, Lyn-Marie Birkholtz, Claire Le Manach, Sergio Wittlin, Ric N. Price, María Belén Jiménez-Díaz, Lubbe Wiesner, Jutta Marfurt, Didier Leroy, David Waterson, Peter Siegl, Christel Brunschwig, Paul V. Fish, Aloysius T. Nchinda, Manu Vanaerschot, Jacob A. McPhail, Mariëtte van der Watt, Dale Taylor, Susan A. Charman, Gregory S. Basarab, Carmen de Kock, Esperanza Herreros, John E. Burke, Suresh Solapure, Kennan C. Marsh, Francisco-Javier Gamo, Kelly Chibale, Theresa L. Coetzer, James Duffy, Rosemary Rochford, Janette Reader, Paolo Denti, Dennis A. Smith, Benjamin Blasco
Publikováno v:
Antimicrobial Agents and Chemotherapy. 62
Autor:
Christel Brunschwig, Sergio Wittlin, Claire Le Manach, Mathew Njoroge, Paul V. Fish, Aloysius T. Nchinda, Dale Taylor, Liezl Gibhard, Nina Lawrence, Kelly Chibale, Kathryn J. Wicht, James Duffy, Charles J. Eyermann, Tanya Paquet, Gregory S. Basarab, Leslie J. Street
Publikováno v:
Journal of medicinal chemistry. 61(20)
A lead-optimization program around a 2,6-imidazopyridine scaffold was initiated based on the two early lead compounds, 1 and 2, that were shown to be efficacious in an in vivo humanized Plasmodium falciparum NODscidIL2Rγnull mouse malaria infection
Autor:
André Horatscheck, Ana Andrijevic, Aloysius T. Nchinda, Claire Le Manach, Tanya Paquet, Lutete Peguy Khonde, Jean Dam, Kailash Pawar, Dale Taylor, Nina Lawrence, Christel Brunschwig, Liezl Gibhard, Mathew Njoroge, Janette Reader, Mariëtte van der Watt, Kathryn Wicht, Ana Carolina C. de Sousa, John Okombo, Keletso Maepa, Timothy J. Egan, Lyn-Marie Birkholtz, Gregory S. Basarab, Sergio Wittlin, Paul V. Fish, Leslie J. Street, James Duffy, Kelly Chibale
Publikováno v:
Journal of Medicinal Chemistry. 64:1762-1762