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pro vyhledávání: '"Aloys Lueken"'
Autor:
Toni Weinhage, Timo Wirth, Paula Schütz, Philipp Becker, Aloys Lueken, Boris V. Skryabin, Helmut Wittkowski, Dirk Foell
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Background: The receptor for advanced glycation end products (RAGE) is a multiligand receptor involved in a number of processes and disorders. While it is known that RAGE-signaling can contribute to toxic liver damage and fibrosis, its role in acute
Externí odkaz:
https://doaj.org/article/d8837fd0bfc24332817bb5dad0e379c5
Autor:
Aloys Lueken, Toni Weinhage, Dirk Foell, Philipp Becker, Paula Schütz, Boris V. Skryabin, Timo Wirth, Helmut Wittkowski
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Frontiers in Immunology
Background: The receptor for advanced glycation end products (RAGE) is a multiligand receptor involved in a number of processes and disorders. While it is known that RAGE-signaling can contribute to toxic liver damage and fibrosis, its role in acute
Autor:
Aloys Lueken, Johannes Roth, Mirco Schmolke, Stephan Ludwig, Dorothee Viemann, Helmut Wittkowski, Yvonne Boergeling, Judith Friesenhagen
Publikováno v:
Journal of Immunology, Vol. 186, No 1 (2011) pp. 164-173
H5N1 influenza virus infections in humans cause a characteristic systemic inflammatory response syndrome; however, the molecular mechanisms are largely unknown. Endothelial cells (ECs) play a pivotal role in hyperdynamic septic diseases. To unravel s
Autor:
Frank Kannenberg, Guenther Bode, Gerd Assmann, Udo Seedorf, Jerzy-Roch Nofer, Markus Knop, Thomas Engel, Aloys Lueken
Publikováno v:
FEBS Letters. 580:4551-4559
The ATP-binding cassette transporter ABCG1 mediates the transport of excess cholesterol from macrophages and other cell types to high density lipoprotein (HDL) but not to lipid-depleted apolipoprotein AI. Several splice variants which may have differ
Publikováno v:
Biochemical and Biophysical Research Communications. 320:1337-1341
Ezetimibe belongs to a group of selective and very effective 2-azetidione cholesterol absorption inhibitors which act on the level of cholesterol entry into enterocytes. Recent data indicated that the drug prevents the formation of a heterocomplex co
Autor:
Thomas Engel, Arnold von Eckardstein, Andrea Cignarella, Aloys Lueken, Paul Cullen, Gerd Assmann, Stefan Lorkowski, Mario Kratz
Publikováno v:
Atherosclerosis. 179(2)
Cholesterol efflux from human monocyte-derived macrophages in the absence of exogenous acceptors has been described, but is unclear in mechanism. We investigated this process in relation to the expression of relevant genes, intracellular cholesterol
Autor:
Gudula Berger, Stefan Lorkowski, Thomas Engel, Paul Cullen, Gerd Assmann, Bernhard Schlüter, Stephan Rust, Aloys Lueken
Publikováno v:
Biochemical and biophysical research communications. 288(2)
Here we report the induction of gene expression of ABCG4, a member of the ABC transporter subfamily G, from human macrophages by oxysterols and retinoids, agonists of the nuclear receptors LXR and RXR. The cloned ABCG4 transcript has a size of 3.5 kb
Publikováno v:
Free radical biologymedicine. 28(5)
Tetrachlorohydroquinone (TCHQ) has been identified as a major toxic metabolite of the widely used wood preservative pentachlorophenol and has also been implicated in its genotoxicity. We have recently demonstrated that protection by the trihydroxamat