Gene expression profiling identifies FLT3 mutation-like cases in wild-type FLT3 acute myeloid leukemia

Autor: Mosquera Orgueira A, Peleteiro Raíndo A, Cid López M, Antelo Rodríguez B, Díaz Arias JÁ, Ferreiro Ferro R, Alonso Vence N, Bendaña López Á, Abuín Blanco A, Bao Pérez L, Melero Valentín P, González Pérez MS, Cerchione C, Martinelli G, Montesinos Fernández P, Pérez Encinas MM, Bello López JL

Publikováno v: Plos One
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname

FLT3 mutation is present in 25-30% of all acute myeloid leukemias (AML), and it is associated with adverse outcome. FLT3 inhibitors have shown improved survival results in AML both as upfront treatment and in relapsed/refractory disease. Curiously, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::e0c49a1fa9824bee0ae545250708af27
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=13884

Survival prediction and treatment optimization of multiple myeloma patients using machine-learning models based on clinical and gene expression data.

Autor: Mosquera Orgueira A; Health Research Institute of Santiago de Compostela (IDIS), Compostela, Spain.; Department of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Compostela, Spain.; University of Santiago de Compostela, Compostela, Spain., González Pérez MS; Health Research Institute of Santiago de Compostela (IDIS), Compostela, Spain.; Department of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Compostela, Spain., Díaz Arias JÁ; Health Research Institute of Santiago de Compostela (IDIS), Compostela, Spain.; Department of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Compostela, Spain.; University of Santiago de Compostela, Compostela, Spain., Antelo Rodríguez B; Health Research Institute of Santiago de Compostela (IDIS), Compostela, Spain.; Department of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Compostela, Spain.; University of Santiago de Compostela, Compostela, Spain., Alonso Vence N; Health Research Institute of Santiago de Compostela (IDIS), Compostela, Spain.; Department of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Compostela, Spain., Bendaña López Á; Health Research Institute of Santiago de Compostela (IDIS), Compostela, Spain.; Department of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Compostela, Spain., Abuín Blanco A; Health Research Institute of Santiago de Compostela (IDIS), Compostela, Spain.; Department of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Compostela, Spain., Bao Pérez L; Health Research Institute of Santiago de Compostela (IDIS), Compostela, Spain.; Department of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Compostela, Spain., Peleteiro Raíndo A; Health Research Institute of Santiago de Compostela (IDIS), Compostela, Spain.; Department of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Compostela, Spain., Cid López M; Health Research Institute of Santiago de Compostela (IDIS), Compostela, Spain.; Department of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Compostela, Spain., Pérez Encinas MM; Health Research Institute of Santiago de Compostela (IDIS), Compostela, Spain.; Department of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Compostela, Spain.; University of Santiago de Compostela, Compostela, Spain., Bello López JL; Health Research Institute of Santiago de Compostela (IDIS), Compostela, Spain.; Department of Hematology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Compostela, Spain.; University of Santiago de Compostela, Compostela, Spain., Mateos Manteca MV; Hospital Universitario de Salamanca, Instituto de Investigación Biomédica de Salamanca (IBSAL), Centro de Investigación del Cancer (IBMCC-USAL, CSIC), Salamanca, Spain. mvmateos@usal.es.

Publikováno v: Leukemia [Leukemia] 2021 Oct; Vol. 35 (10), pp. 2924-2935. Date of Electronic Publication: 2021 May 18.

Personalized Survival Prediction of Patients With Acute Myeloblastic Leukemia Using Gene Expression Profiling.

Autor: Mosquera Orgueira A; University Hospital of Santiago de Compostela (SERGAS), Department of Hematology, Santiago de Compostela, Spain.; Health Research Institute of Santiago de Compostela, Grupo de Investigación en Síndromes Linfoproliferativos, Santiago de Compostela, Spain.; Departamento de Medicina, University of Santiago de Compostela, Santiago de Compostela, Spain., Peleteiro Raíndo A; University Hospital of Santiago de Compostela (SERGAS), Department of Hematology, Santiago de Compostela, Spain.; Health Research Institute of Santiago de Compostela, Grupo de Investigación en Síndromes Linfoproliferativos, Santiago de Compostela, Spain.; Departamento de Medicina, University of Santiago de Compostela, Santiago de Compostela, Spain., Cid López M; University Hospital of Santiago de Compostela (SERGAS), Department of Hematology, Santiago de Compostela, Spain.; Health Research Institute of Santiago de Compostela, Grupo de Investigación en Síndromes Linfoproliferativos, Santiago de Compostela, Spain.; Departamento de Medicina, University of Santiago de Compostela, Santiago de Compostela, Spain., Díaz Arias JÁ; University Hospital of Santiago de Compostela (SERGAS), Department of Hematology, Santiago de Compostela, Spain.; Health Research Institute of Santiago de Compostela, Grupo de Investigación en Síndromes Linfoproliferativos, Santiago de Compostela, Spain., González Pérez MS; University Hospital of Santiago de Compostela (SERGAS), Department of Hematology, Santiago de Compostela, Spain.; Health Research Institute of Santiago de Compostela, Grupo de Investigación en Síndromes Linfoproliferativos, Santiago de Compostela, Spain., Antelo Rodríguez B; University Hospital of Santiago de Compostela (SERGAS), Department of Hematology, Santiago de Compostela, Spain.; Health Research Institute of Santiago de Compostela, Grupo de Investigación en Síndromes Linfoproliferativos, Santiago de Compostela, Spain.; Departamento de Medicina, University of Santiago de Compostela, Santiago de Compostela, Spain., Alonso Vence N; University Hospital of Santiago de Compostela (SERGAS), Department of Hematology, Santiago de Compostela, Spain.; Health Research Institute of Santiago de Compostela, Grupo de Investigación en Síndromes Linfoproliferativos, Santiago de Compostela, Spain.; Departamento de Medicina, University of Santiago de Compostela, Santiago de Compostela, Spain., Bao Pérez L; University Hospital of Santiago de Compostela (SERGAS), Department of Hematology, Santiago de Compostela, Spain.; Health Research Institute of Santiago de Compostela, Grupo de Investigación en Síndromes Linfoproliferativos, Santiago de Compostela, Spain.; Departamento de Medicina, University of Santiago de Compostela, Santiago de Compostela, Spain., Ferreiro Ferro R; University Hospital of Santiago de Compostela (SERGAS), Department of Hematology, Santiago de Compostela, Spain.; Health Research Institute of Santiago de Compostela, Grupo de Investigación en Síndromes Linfoproliferativos, Santiago de Compostela, Spain., Albors Ferreiro M; University Hospital of Santiago de Compostela (SERGAS), Department of Hematology, Santiago de Compostela, Spain.; Health Research Institute of Santiago de Compostela, Grupo de Investigación en Síndromes Linfoproliferativos, Santiago de Compostela, Spain., Abuín Blanco A; University Hospital of Santiago de Compostela (SERGAS), Department of Hematology, Santiago de Compostela, Spain.; Health Research Institute of Santiago de Compostela, Grupo de Investigación en Síndromes Linfoproliferativos, Santiago de Compostela, Spain., Fontanes Trabazo E; University Hospital of Santiago de Compostela (SERGAS), Department of Hematology, Santiago de Compostela, Spain.; Health Research Institute of Santiago de Compostela, Grupo de Investigación en Síndromes Linfoproliferativos, Santiago de Compostela, Spain., Cerchione C; Hematology Unit, Istituto Tumori della Romagna IRST IRCCS, Meldola, Italy., Martinnelli G; Hematology Unit, Istituto Tumori della Romagna IRST IRCCS, Meldola, Italy., Montesinos Fernández P; Hospital Universitari i Politècnic La Fe, Department of Hematology, Valencia, Spain., Mateo Pérez Encinas M; University Hospital of Santiago de Compostela (SERGAS), Department of Hematology, Santiago de Compostela, Spain.; Health Research Institute of Santiago de Compostela, Grupo de Investigación en Síndromes Linfoproliferativos, Santiago de Compostela, Spain.; Departamento de Medicina, University of Santiago de Compostela, Santiago de Compostela, Spain., Luis Bello López J; University Hospital of Santiago de Compostela (SERGAS), Department of Hematology, Santiago de Compostela, Spain.; Health Research Institute of Santiago de Compostela, Grupo de Investigación en Síndromes Linfoproliferativos, Santiago de Compostela, Spain.; Departamento de Medicina, University of Santiago de Compostela, Santiago de Compostela, Spain.

Publikováno v: Frontiers in oncology [Front Oncol] 2021 Mar 29; Vol. 11, pp. 657191. Date of Electronic Publication: 2021 Mar 29 (Print Publication: 2021).

Improved personalized survival prediction of patients with diffuse large B-cell Lymphoma using gene expression profiling.

Autor: Mosquera Orgueira A; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain. adrian.mosquera@live.com.; Department of Hematology, SERGAS, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Santiago, Spain. adrian.mosquera@live.com.; Hospital Clínico Universitario de Santiago de Compostela, Servicio de Hematología, planta 1, Avenida da Choupana s/n, 15706, Santiago de Compostela, Spain. adrian.mosquera@live.com.; University of Santiago de Compostela, Santiago de Compostela, Spain. adrian.mosquera@live.com., Díaz Arias JÁ; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.; Department of Hematology, SERGAS, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Santiago, Spain.; University of Santiago de Compostela, Santiago de Compostela, Spain., Cid López M; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.; Department of Hematology, SERGAS, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Santiago, Spain., Peleteiro Raíndo A; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.; Department of Hematology, SERGAS, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Santiago, Spain., Antelo Rodríguez B; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.; Department of Hematology, SERGAS, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Santiago, Spain.; University of Santiago de Compostela, Santiago de Compostela, Spain., Aliste Santos C; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.; Department of Pathology, SERGAS, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Santiago de Compostela, Spain., Alonso Vence N; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.; Department of Hematology, SERGAS, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Santiago, Spain., Bendaña López Á; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.; Department of Hematology, SERGAS, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Santiago, Spain., Abuín Blanco A; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.; Department of Hematology, SERGAS, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Santiago, Spain., Bao Pérez L; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.; Department of Hematology, SERGAS, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Santiago, Spain., González Pérez MS; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.; Department of Hematology, SERGAS, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Santiago, Spain., Pérez Encinas MM; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.; Department of Hematology, SERGAS, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Santiago, Spain.; University of Santiago de Compostela, Santiago de Compostela, Spain., Fraga Rodríguez MF; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.; University of Santiago de Compostela, Santiago de Compostela, Spain.; Department of Pathology, SERGAS, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Santiago de Compostela, Spain., Bello López JL; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.; Department of Hematology, SERGAS, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Santiago, Spain.; University of Santiago de Compostela, Santiago de Compostela, Spain.

Publikováno v: BMC cancer [BMC Cancer] 2020 Oct 21; Vol. 20 (1), pp. 1017. Date of Electronic Publication: 2020 Oct 21.

Novel Mutation Hotspots within Non-Coding Regulatory Regions of the Chronic Lymphocytic Leukemia Genome.

Autor: Mosquera Orgueira A; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain. adrian.mosquera@live.com.; Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Division of Hematology, SERGAS, Santiago de Compostela, Spain. adrian.mosquera@live.com.; University of Santiago de Compostela, Santiago de Compostela, Spain. adrian.mosquera@live.com., Rodríguez Antelo B; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.; Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Division of Hematology, SERGAS, Santiago de Compostela, Spain.; University of Santiago de Compostela, Santiago de Compostela, Spain., Díaz Arias JÁ; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.; Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Division of Hematology, SERGAS, Santiago de Compostela, Spain., Díaz Varela N; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.; Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Division of Hematology, SERGAS, Santiago de Compostela, Spain., Alonso Vence N; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.; Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Division of Hematology, SERGAS, Santiago de Compostela, Spain., González Pérez MS; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.; Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Division of Hematology, SERGAS, Santiago de Compostela, Spain., Bello López JL; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.; Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Division of Hematology, SERGAS, Santiago de Compostela, Spain.; University of Santiago de Compostela, Santiago de Compostela, Spain.

Publikováno v: Scientific reports [Sci Rep] 2020 Feb 12; Vol. 10 (1), pp. 2407. Date of Electronic Publication: 2020 Feb 12.