Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Alona Epshtein"'
Autor:
Guzel Burganova, Anat Schonblum, Lina Sakhneny, Alona Epshtein, Tomer Wald, Mika Tzaig, Limor Landsman
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionImmune cells were recently shown to support β-cells and insulin secretion. However, little is known about how islet immune cells are regulated to maintain glucose homeostasis. Administration of various cytokines, including Interleukin-33
Externí odkaz:
https://doaj.org/article/5bb295c115024a1d86543465a537de3e
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract β-Cells depend on the islet basement membrane (BM). While some islet BM components are produced by endothelial cells (ECs), the source of others remains unknown. Pancreatic pericytes directly support β-cells through mostly unidentified sec
Externí odkaz:
https://doaj.org/article/04c49dec808b409ab8df48674718bbbd
Publikováno v:
Molecular Metabolism, Vol 6, Iss 10, Pp 1330-1338 (2017)
Objective: The maintenance and expansion of β-cell mass rely on their proliferation, which reaches its peak in the neonatal stage. β-cell proliferation was found to rely on cells of the islet microenvironment. We hypothesized that pericytes, which
Externí odkaz:
https://doaj.org/article/3413ca3a5f9347d2bafa4222dd64acae
Autor:
Lina Sakhneny, Francesca M. Spagnoli, Laura Mueller, Anat Schonblum, Guzel Burganova, Abigail Isaacson, Heather Wilson, Sivan Azaria, Limor Landsman, Alona Epshtein
Publikováno v:
Developmental cell. 56(19)
Glucose homeostasis depends on regulated insulin secretion from pancreatic β cells, which acquire their mature phenotype postnatally. The functional maturation of β cells is regulated by a combination of cell-autonomous and exogenous factors; the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c867396bf2e6497491f92cd5589b5305
https://pubmed.ncbi.nlm.nih.gov/34499867
https://pubmed.ncbi.nlm.nih.gov/34499867
Autor:
Alona Epshtein, Lina Sakhneny, Daria Baer, Adi Sasson, Limor Landsman, Eleonor Rachi, Michal Lisnyansky
Publikováno v:
Diabetes. 65:3008-3014
β-Cells rely on the islet microenvironment for their functionality and mass. Pericytes, along with endothelial cells, make up the dense islet capillary network. However, although the role of endothelial cells in supporting β-cell homeostasis has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d714118325c4bd4c8e3c70d3bb4f828
https://doi.org/10.2337/db16-0365
https://doi.org/10.2337/db16-0365
Autor:
Thomas Vogl, Shai Weiss, Isabel Zvibel, Sigal Fishman, Yael Kuperman, Keren Cohen, Fernanda Dana Mantelmacher, Alona Epshtein, Chen Varol, Metsada Pasmanik-Chor, Daniel J. Drucker
Publikováno v:
Nature metabolism. 1(1)
Enteroendocrine cells relay energy-derived signals to immune cells to signal states of nutrient abundance and control immunometabolism. Emerging data suggest that the gut-derived nutrient-induced incretin glucose-dependent insulinotropic polypeptide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99054ea32577b0ae917a671c723ae866
https://pubmed.ncbi.nlm.nih.gov/32694806
https://pubmed.ncbi.nlm.nih.gov/32694806
Autor:
Shane Wald-Altman, Lina Sakhneny, Alona Epshtein, Laura Khalifa-Malka, Miguel Weil, Daria Baer, Adina Hazan, Michal Lisnyansky, Helen C. Guez, Eleonor Rachi, Avi Priel, Limor Landsman
Publikováno v:
Diabetes. 67(3)
Polymorphism in TCF7L2, a component of the canonical Wnt signaling pathway, has a strong association with β-cell dysfunction and type 2 diabetes through a mechanism that has yet to be defined. β-Cells rely on cells in their microenvironment, includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f55643b8b6a254686acda8b57a40fec
https://pubmed.ncbi.nlm.nih.gov/29246974
https://pubmed.ncbi.nlm.nih.gov/29246974
Publikováno v:
Scientific Reports
Pancreas development requires restrained Hedgehog (Hh) signaling activation. While deregulated Hh signaling in the pancreatic mesenchyme has been long suggested to be detrimental for proper organogenesis, this association was not directly shown. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07930b24b645dd9badc0dede7abcccf1
https://pubmed.ncbi.nlm.nih.gov/27892540
https://pubmed.ncbi.nlm.nih.gov/27892540