Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Alona, Shaldubina"'
Publikováno v:
Acta neuropsychiatrica. 14(5)
Background:Eicosapentaenoic acid (EPA) is one of the major components of fish oils. Omega-3 fatty acids, particularly EPA, have been hypothesized to play a role in the etiology, pathogenesis and treatment of mood disorders. Clinical studies have show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80f9a850dbb679c3a5d474cf09e6ccb6
https://pubmed.ncbi.nlm.nih.gov/26984457
https://pubmed.ncbi.nlm.nih.gov/26984457
Autor:
Einav Sudai, Gal Yadid, Moshe Ben-Tzion, Noa Kinor, Yakov Flaumenhaft, Iris Gispan, Ofri Croitoru, Shai Aharoni, Lital Abraham, Alona Shaldubina, Ilana Roth-Deri
Publikováno v:
Addiction Biology. 16:251-260
Drug addiction is a chronic brain disorder, characterized by the loss of the ability to control drug consumption. The neurobiology of addiction is traditionally thought to involve the mesocorticolimbic system of the brain. However, the hippocampus ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8db5be644a104eb41cfaaf449a676b71
https://doi.org/10.1111/j.1369-1600.2010.00241.x
https://doi.org/10.1111/j.1369-1600.2010.00241.x
Publikováno v:
Bipolar Disorders. 10:453-459
Objective: Lithium inhibits inositol monophosphatase and also reduces inositol transporter function. To determine if one or more of these mechanisms might underlie the behavioral effects of lithium, we studied inositol transporter knockout mice. We p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c262094d51b0142478c03fa4a17cef96
https://doi.org/10.1111/j.1399-5618.2007.00546.x
https://doi.org/10.1111/j.1399-5618.2007.00546.x
Autor:
Yuly Bersudsky, Alona Shaldubina, Robert H. Belmaker, Nitzan Kozlovsky, James R. Woodgett, Galila Agam
Publikováno v:
Behavioural Pharmacology. 19:217-224
In mice glycogen synthase kinase (GSK)-3beta heterozygote knockout status was reported to cause reduced immobility in the Porsolt forced swim test and reduced amphetamine-induced hyperactivity, behaviors that mimic the effects of lithium. GSK-3beta p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ffeb955f0ffde2f1a4c04261a071064
https://doi.org/10.1097/fbp.0b013e3282feb099
https://doi.org/10.1097/fbp.0b013e3282feb099
Autor:
W. Timothy O'Brien, Peter S. Klein, Yuly Bersudsky, Robert H. Belmaker, Roberto Buccafusca, Galila Agam, Roy A. Johanson, Alona Shaldubina, Gerard T. Berry
Publikováno v:
Molecular Genetics and Metabolism. 88:384-388
Two leading hypotheses to explain lithium action in bipolar disorder propose either inositol depletion or inhibition of GSK-3 as mechanisms of action. Behavioral effects of lithium are mimicked in Gsk-3β +/− mice, but the contribution of inositol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45bdee42f26e1086b18435aff5f6d345
https://doi.org/10.1016/j.ymgme.2006.03.007
https://doi.org/10.1016/j.ymgme.2006.03.007
Autor:
Alona Shaldubina, Ziva Stahl, Joseph Shapiro, Yuly Bersudsky, Mariala Furszpan, Robert H. Belmaker, William T. Regenold
Publikováno v:
Bipolar Disorders. 8:152-159
Objectives: A major hypothesis explaining the therapeutic effect of lithium (Li) in mania is depletion of inositol via inhibition of inositol monophosphatase. However, inositol is also present in the diet. Restriction of dietary inositol could theore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a680f72ee914a30e6d23703749d8ddd1
https://doi.org/10.1111/j.1399-5618.2006.00290.x
https://doi.org/10.1111/j.1399-5618.2006.00290.x
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 25:855-866
Lithium is an effective drug for both treatment and prophylaxis of bipolar disorder. However, the mechanism of lithium action is still unknown. The inositol depletion hypothesis is supported by biochemical and behavioral data in rats, but primate ino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bb32211f88ee3346a56525a2df41d65
https://doi.org/10.1016/s0278-5846(01)00154-3
https://doi.org/10.1016/s0278-5846(01)00154-3
Publikováno v:
Behavioural Brain Research. 118:77-83
The effect of inositol as an antidepressant was previously demonstrated in both animal models of depression-like behavior and in clinical trials. Unlike most antidepressant drugs, inositol does not have a clear target in the synapse and was not demon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e27a511c5588b2768a8d4dc0a75ae166
https://doi.org/10.1016/s0166-4328(00)00314-4
https://doi.org/10.1016/s0166-4328(00)00314-4
Publikováno v:
Drug Development Research. 50:309-315
Inositol is a simple polyol precursor in a second messenger system important in the brain. A double-blind controlled trial of 12 g daily of inositol in 28 patients with depression for 4 weeks found significant benefit for inositol compared to placebo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::921528c4588aa6dae77d1c1409a239ec
https://doi.org/10.1002/1098-2299(200007/08)50:3/4<309::aid-ddr14>3.0.co
https://doi.org/10.1002/1098-2299(200007/08)50:3/4<309::aid-ddr14>3.0.co
Autor:
Alex Kaptsan, Nimrod Grisaru, Alona Shaldubina, Bella Chudakov, Robert H. Belmaker, Julia Applebaum
This article reviews the existing animal and human literature on the clinical potential of transcranial magnetic stimulation (TMS) in mania and bipolar depression, and discusses potential future directions for this work. Studies of TMS in depression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c905680ce68c30888bb41f8e96d0637b
https://doi.org/10.1093/oxfordhb/9780198568926.013.0041
https://doi.org/10.1093/oxfordhb/9780198568926.013.0041
