Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Alona, Kulesha"'
Autor:
Areetha D’Souza, Liam R. Marshall, Jennifer Yoon, Alona Kulesha, Dona I. U. Edirisinghe, Siddarth Chandrasekaran, Parth Rathee, Rajeev Prabhakar, Olga V. Makhlynets
Publikováno v:
Nano Convergence, Vol 9, Iss 1, Pp 1-8 (2022)
Abstract We have rationally designed a peptide that assembles into a redox-responsive, antimicrobial metallohydrogel. The resulting self-healing material can be rapidly reduced by ascorbate under physiological conditions and demonstrates a remarkable
Externí odkaz:
https://doaj.org/article/84ba9b91efee4c9ab5c98ea3ba16ac76
Autor:
Sagar Bhattacharya, Eleonora G. Margheritis, Katsuya Takahashi, Alona Kulesha, Areetha D’Souza, Inhye Kim, Jennifer H. Yoon, Jeremy R. H. Tame, Alexander N. Volkov, Olga V. Makhlynets, Ivan V. Korendovych
Publikováno v:
Nature. 610:389-393
Publikováno v:
Biomolecules, Vol 11, Iss 3, p 421 (2021)
Antimicrobial peptides (AMPs) present a promising scaffold for the development of potent antimicrobial agents. Substitution of tryptophan by non-natural amino acid Azulenyl-Alanine (AzAla) would allow studying the mechanism of action of AMPs by using
Externí odkaz:
https://doaj.org/article/0da4b2b2f3e34ecb9d888f436efe3848
Autor:
Areetha D’Souza, Liam R. Marshall, Jennifer Yoon, Alona Kulesha, Dona I. U. Edirisinghe, Siddarth Chandrasekaran, Parth Rathee, Rajeev Prabhakar, Olga V. Makhlynets
Publikováno v:
Nano convergence. 9(1)
We have rationally designed a peptide that assembles into a redox-responsive, antimicrobial metallohydrogel. The resulting self-healing material can be rapidly reduced by ascorbate under physiological conditions and demonstrates a remarkable 160-fold
Autor:
Ivan Korendovych, Sagar Bhattacharya, Eleanora Margheritis, Katsuya Takahashi, Alona Kulesha, Areetha D'Souza, Inhye Kim, Jeremy Tame, Jennifer Yoon, Alexander Volkov, Olga Makhlynets
Directed evolution can rapidly achieve dramatic improvements in the properties of a protein or bestow entirely new functions on it. We have discovered a strong correlation between the probability of finding a productive mutation at a particular posit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4950de2418c8971d5aa72a2bcb8bd96
https://doi.org/10.21203/rs.3.rs-1150236/v1
https://doi.org/10.21203/rs.3.rs-1150236/v1
Autor:
Sagar, Bhattacharya, Eleonora G, Margheritis, Katsuya, Takahashi, Alona, Kulesha, Areetha, D'Souza, Inhye, Kim, Jennifer H, Yoon, Jeremy R H, Tame, Alexander N, Volkov, Olga V, Makhlynets, Ivan V, Korendovych
Publikováno v:
Nature. 610(7931)
Directed evolution is a powerful tool for improving existing properties and imparting completely new functionalities to proteins
Autor:
Olga V. Makhlynets, Areetha D'Souza, Elizabeth R. Caselle, Alona Kulesha, Alexander N. Volkov, Joel J. L. Rempillo, Christos Costeas, Zsofia Lengyel-Zhand, Jennifer H. Yoon, Cara Chester
Publikováno v:
Chemistry
Metalloenzymes often utilize radicals in order to facilitate chemical reactions. Recently, DeGrado and coworkers have discovered that model proteins can efficiently stabilize semiquinone radical anion produced by oxidation of 3,5-di-tert-butylcatecho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33339bf8969ed07dd5ec2392c26ee450
https://europepmc.org/articles/PMC6891133/
https://europepmc.org/articles/PMC6891133/
Autor:
Alona Kulesha, Jennifer H. Yoon, Areetha D'Souza, Olga V. Makhlynets, Cara Chester, Christos Costeas
Publikováno v:
Journal of Inorganic Biochemistry. 212:111224
Metalloproteins constitute nearly half of all proteins and catalyze some of the most complex chemical reactions. Recently, we reported a design of 4G-UFsc (Uno Ferro single chain), a single chain four-helical bundle with extraordinarily high (30 pM)