Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Alon Lai"'
Autor:
Alon Lai, Denise Iliff, Kashaf Zaheer, Jennifer Gansau, Damien M. Laudier, Venetia Zachariou, James C. Iatridis
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1762 (2024)
Chronic painful intervertebral disc (IVD) degeneration (i.e., discogenic pain) is a major source of global disability needing improved knowledge on multiple-tissue interactions and how they progress in order improve treatment strategies. This study u
Externí odkaz:
https://doaj.org/article/75d9ffc03fd64012be12f8a682c69cce
Autor:
Alon Lai, Denise Iliff, Kashaf Zaheer, Dalin Wang, Jennifer Gansau, Damien M. Laudier, Venetia Zachariou, James C. Iatridis
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3425 (2023)
Intervertebral disc (IVD) degeneration with Modic-like changes is strongly associated with pain. Lack of effective disease-modifying treatments for IVDs with endplate (EP) defects means there is a need for an animal model to improve understanding of
Externí odkaz:
https://doaj.org/article/e3bdd6b53a2041dca2901cacd237f033
Autor:
Sarah E. Gullbrand, Beth G. Ashinsky, Alon Lai, Jennifer Gansau, James Crowley, Carla Cunha, Julie B. Engiles, Marion Fusellier, Carol Muehleman, Matthew Pelletier, Steven Presciutti, Jordy Schol, Yoshiki Takeoka, Takashi Yurube, Yejia Zhang, Koichi Masuda, James C. Iatridis
Publikováno v:
JOR Spine, Vol 4, Iss 2, Pp n/a-n/a (2021)
Abstract Background The rabbit lumbar spine is a commonly utilized model for studying intervertebral disc degeneration and for the pre‐clinical evaluation of regenerative therapies. Histopathology is the foundation for which alterations to disc mor
Externí odkaz:
https://doaj.org/article/b3459f50ee684517ac802771d06a3cf6
Autor:
Alon Lai, Jennifer Gansau, Sarah E. Gullbrand, James Crowley, Carla Cunha, Stefan Dudli, Julie B. Engiles, Marion Fusellier, Raquel M. Goncalves, Daisuke Nakashima, Jeffrey Okewunmi, Matthew Pelletier, Steven M. Presciutti, Jordy Schol, Yoshiki Takeoka, Sidong Yang, Takashi Yurube, Yejia Zhang, James C. Iatridis
Publikováno v:
JOR Spine, Vol 4, Iss 2, Pp n/a-n/a (2021)
Abstract Background Rats are a widely accepted preclinical model for evaluating intervertebral disc (IVD) degeneration and regeneration. IVD morphology is commonly assessed using histology, which forms the foundation for quantifying the state of IVD
Externí odkaz:
https://doaj.org/article/701a2b7974e448fda80b7a31a3170428
Autor:
Chitra L. Dahia, Julie B. Engiles, Sarah E. Gullbrand, James C. Iatridis, Alon Lai, Christine L. Le Maitre, Jeffrey C. Lotz, Koichi Masuda, Cheryle A. Séguin, Marianna A. Tryfonidou
Publikováno v:
JOR Spine, Vol 4, Iss 2, Pp n/a-n/a (2021)
Externí odkaz:
https://doaj.org/article/2949e6636e8a428584b86baa9cafd9e5
Autor:
Devorah M Natelson, Alon Lai, Divya Krishnamoorthy, Robert C Hoy, James C Iatridis, Svenja Illien-Jünger
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0227527 (2020)
Type 2 diabetes and obesity are associated with back pain in juveniles and adults and are implicated in intervertebral disc (IVD) degeneration. Hypercaloric Western diets are associated with both obesity and type 2 diabetes. The objective of this stu
Externí odkaz:
https://doaj.org/article/96d5e4c409cb45338ed2d60d9828eb94
Autor:
Alon Lai, Lap Ho, Thomas W Evashwick-Rogler, Hironobu Watanabe, Jonathan Salandra, Beth A Winkelstein, Damien Laudier, Andrew C Hecht, Giulio M Pasinetti, James C Iatridis
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0225674 (2019)
[This corrects the article DOI: 10.1371/journal.pone.0223435.].
Externí odkaz:
https://doaj.org/article/e479ee6b189e401086ce53da05f478f1
Autor:
Alon Lai, Lap Ho, Thomas W Evashwick-Rogler, Hironobu Watanabe, Jonathan Salandra, Beth A Winkelstein, Damien Laudier, Andrew C Hecht, Giulio M Pasinetti, James C Iatridis
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0223435 (2019)
Developing effective therapies for back pain associated with intervertebral disc (IVD) degeneration is a research priority since it is a major socioeconomic burden and current conservative and surgical treatments have limited success. Polyphenols are
Externí odkaz:
https://doaj.org/article/2d3a83857bdd4963a72bdadab1e4d815
Autor:
Thomas W. Evashwick‐Rogler, Alon Lai, Hironobu Watanabe, Jonathan M. Salandra, Beth A. Winkelstein, Samuel K. Cho, Andrew C. Hecht, James C. Iatridis
Publikováno v:
JOR Spine, Vol 1, Iss 2, Pp n/a-n/a (2018)
Background Painful intervertebral disc (IVD) degeneration has tremendous societal costs and few effective therapies. Intradiscal tumor necrosis factor‐alpha (TNFα) is commonly associated with low back pain, but the direct relationship remains uncl
Externí odkaz:
https://doaj.org/article/45b870f1dfcc4e7fb71a3fc72dac86c5
Autor:
Michael Frohbergh, Yi Ge, Fanli Meng, Nesrin Karabul, Alexander Solyom, Alon Lai, James Iatridis, Edward H Schuchman, Calogera M Simonaro
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100882 (2014)
BACKGROUND:We previously demonstrated the benefits of daily, oral pentosan polysulfate (PPS) treatment in a rat model of mucopolysaccharidosis (MPS) type VI. Herein we compare these effects to once weekly, subcutaneous (s.c.) injection. The bioavaila
Externí odkaz:
https://doaj.org/article/33938f5f1c0446a886807e8274d52f6b