Zobrazeno 1 - 10
of 190
pro vyhledávání: '"Alon Korngreen"'
Publikováno v:
Journal of Computational Neuroscience. 51:263-282
To understand single neuron computation, it is necessary to know how specific physiological parameters affect neural spiking patterns that emerge in response to specific stimuli. Here we present a computational pipeline combining biophysical and stat
Autor:
Lilach Gorodetski, Yocheved Loewenstern, Anna Faynveitz, Izhar Bar-Gad, Kim T. Blackwell, Alon Korngreen
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
The entopeduncular nucleus is one of the basal ganglia's output nuclei, thereby controlling basal ganglia information processing. Entopeduncular nucleus neurons integrate GABAergic inputs from the Striatum and the globus pallidus, together with gluta
Externí odkaz:
https://doaj.org/article/63cddd9edc1b4cc89107f2c6da34ff99
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
The substantia nigra pars reticulata (SNr) is one of the output nuclei of the basal ganglia (BG) and plays a vital role in movement execution. Death of dopaminergic neurons in the neighboring nucleus, the substantia nigra pars compacta (SNc), leads t
Externí odkaz:
https://doaj.org/article/d15eb3b8cfff4b3bbb18038f6f752a8d
Autor:
Sophia Kriegeskorte, Raya Bott, Martin Hampl, Alon Korngreen, Ralf Hausmann, Angelika Lampert
Voltage-gated sodium channels (Nav) are key players in excitable tissues with the capability to generate and propagate action potentials. Mutations in the genes encoding Navs can lead to severe inherited diseases, and some of these so-called channelo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1315e0b87af6e31fdb936e77f0df4a86
https://doi.org/10.1101/2022.12.19.521077
https://doi.org/10.1101/2022.12.19.521077
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Exploring the properties of action potentials is a crucial step toward a better understanding of the computational properties of single neurons and neural networks. The voltage-gated sodium channel is a key player in action potential generation. A co
Externí odkaz:
https://doaj.org/article/28201a794ed64962aa7ad3fc4e242215
Changes in basal ganglia processing of cortical input following magnetic stimulation in Parkinsonism
Publikováno v:
Neurobiology of Disease, Vol 48, Iss 3, Pp 464-473 (2012)
Parkinsonism is associated with major changes in neuronal activity throughout the cortico-basal ganglia loop. Current measures quantify changes in baseline neuronal and network activity but do not capture alterations in information propagation throug
Externí odkaz:
https://doaj.org/article/6aa187af9fd444f888e6a8322b88e8fd
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Computational models are crucial to studying the encoding of individual neurons. Static models are composed of a fixed set of parameters, thus resulting in static encoding properties that do not change under different inputs. Here, we challenge this
Autor:
Hersh Sanghevi, Kevin J. Bender, Christopher Cross, Kristofer E. Bouchard, Nikhil S. Artherya, Kyung Geun Kim, Alexander Ladd, Alon Korngreen, Roy Ben-Shalom
Publikováno v:
J Neurosci Methods
Background The membrane potential of individual neurons depends on a large number of interacting biophysical processes operating on spatial-temporal scales spanning several orders of magnitude. The multi-scale nature of these processes dictates that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236f8b1d7891d2b7b919f4bed035ddef
https://europepmc.org/articles/PMC9887806/
https://europepmc.org/articles/PMC9887806/
Like all biological and chemical reactions, ion channel kinetics are highly sensitive to changes in temperature. Therefore, it is prudent to investigate channel dynamics at physiological temperatures. However, most ion channel investigations are perf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3edcf4f6abbf71fbd548f813c175d6d0
https://doi.org/10.1101/2021.09.25.461780
https://doi.org/10.1101/2021.09.25.461780
Publikováno v:
European Journal of Neuroscience. 48:2139-2151
The hyperdirect pathway of the basal ganglia bypasses the striatum, and delivers cortical information directly to the subthalamic nucleus (STN). In rodents, the STN excites the two output nuclei of the basal ganglia, the entopeduncular nucleus (EP) a