Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Alon Keinan"'
Autor:
Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Low frequency coding single-nucleotide variants (SNVs) are predicted to disproportionately affect protein function. Here, the authors evaluate 2,009 missense SNVs across 2,185 protein-protein interactions using yeast two-hybrid and protein complement
Externí odkaz:
https://doaj.org/article/6ca43b750ead45778c9bbf8306bf1546
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Genome-Wide association studies (GWAS), based on testing one single nucleotide polymorphism (SNP) at a time, have revolutionized our understanding of the genetics of complex traits. In GWAS, there is a need to consider confounding effects such as due
Externí odkaz:
https://doaj.org/article/8136c4b98a064aba8187920e64d243ae
Autor:
Yedael Y Waldman, Arjun Biddanda, Natalie R Davidson, Paul Billing-Ross, Maya Dubrovsky, Christopher L Campbell, Carole Oddoux, Eitan Friedman, Gil Atzmon, Eran Halperin, Harry Ostrer, Alon Keinan
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152056 (2016)
The Bene Israel Jewish community from West India is a unique population whose history before the 18th century remains largely unknown. Bene Israel members consider themselves as descendants of Jews, yet the identity of Jewish ancestors and their arri
Externí odkaz:
https://doaj.org/article/82486e4fb7c14e67b5bb94ed2e7d7d6d
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 11, Pp 2425-2428 (2012)
The mixed dyslipidemia phenotype is characterized by elevated triglycerides (TG), low HDL cholesterol (HDL-C), increased ApoB levels, and premature coronary atherosclerosis. Fibrate-statin combination therapy reduces ApoB levels and coronary events i
Externí odkaz:
https://doaj.org/article/23476a01f99d4f27aa69ed56b5414301
Autor:
Fuli Yu, Jian Lu, Xiaoming Liu, Elodie Gazave, Diana Chang, Srilakshmi Raj, Haley Hunter-Zinck, Ran Blekhman, Leonardo Arbiza, Cris Van Hout, Alanna Morrison, Andrew D Johnson, Joshua Bis, L Adrienne Cupples, Bruce M Psaty, Donna Muzny, Jin Yu, Richard A Gibbs, Alon Keinan, Andrew G Clark, Eric Boerwinkle
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121644 (2015)
Whole genome analysis in large samples from a single population is needed to provide adequate power to assess relative strengths of natural selection across different functional components of the genome. In this study, we analyzed next-generation seq
Externí odkaz:
https://doaj.org/article/82d23a2115ca48b08e1cafeb0077e3eb
Autor:
Diana Chang, Alon Keinan
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 9, p e1003820 (2014)
Genome-wide association studies (GWASs) have recently revealed many genetic associations that are shared between different diseases. We propose a method, disPCA, for genome-wide characterization of shared and distinct risk factors between and within
Externí odkaz:
https://doaj.org/article/7750cba233e54e10811b9031ffafb1df
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92469 (2014)
Epistasis has been suggested to underlie part of the missing heritability in genome-wide association studies. In this study, we first report an analysis of gene-gene interactions affecting HDL cholesterol (HDL-C) levels in a candidate gene study of 2
Externí odkaz:
https://doaj.org/article/d8ac5011aa4340fc88117c6ebe6e8237
Autor:
Diana Chang, Feng Gao, Andrea Slavney, Li Ma, Yedael Y Waldman, Aaron J Sams, Paul Billing-Ross, Aviv Madar, Richard Spritz, Alon Keinan
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e113684 (2014)
Many complex human diseases are highly sexually dimorphic, suggesting a potential contribution of the X chromosome to disease risk. However, the X chromosome has been neglected or incorrectly analyzed in most genome-wide association studies (GWAS). W
Externí odkaz:
https://doaj.org/article/2b6b7d9875d94e669bbf80e84b5feb1f
Publikováno v:
PLoS Genetics, Vol 9, Iss 2, p e1003321 (2013)
Various methods have been developed for identifying gene-gene interactions in genome-wide association studies (GWAS). However, most methods focus on individual markers as the testing unit, and the large number of such tests drastically erodes statist
Externí odkaz:
https://doaj.org/article/d8da92e982fa41728b2529cc84c32b92
Publikováno v:
PLoS Genetics, Vol 8, Iss 5, p e1002714 (2012)
Total cholesterol, low-density lipoprotein cholesterol, triglyceride, and high-density lipoprotein cholesterol (HDL-C) levels are among the most important risk factors for coronary artery disease. We tested for gene-gene interactions affecting the le
Externí odkaz:
https://doaj.org/article/6cccbbf2450b4e53955c2f0625a3399f