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pro vyhledávání: '"Alon Abend"'
Autor:
Izhak Kehat, Alon Abend
Publikováno v:
Pharmacology & Therapeutics. 147:55-62
Heart failure is a major public health problem in western society. Recently, agents that inhibit histone deacetylase (HDAC) enzymes were developed and approved by the FDA as anticancer agents. This breakthrough has provided the motivation to develop
Publikováno v:
EMBO reports. 18(7)
A pathologic osteochondrogenic differentiation of vascular smooth muscle cells (VSMCs) promotes arterial calcifications, a process associated with significant morbidity and mortality. The molecular pathways promoting this pathology are not completely
Publikováno v:
Circulation Research. 119
Background: Arterial calcification and valvular calcifications are associated with significant morbidity and mortality. Studies have now conclusively showed that an osteochondrogenic differentiation of vascular smooth muscle cells (VSMC) is a key mec