Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Alokesh Duttaroy"'
Autor:
Rohit N. Kulkarni, Chong Wee Liew, Bryan Burkey, Jiang Hu, Dan Kawamori, Alokesh Duttaroy, Jun Shirakawa, Tomoaki Morioka
Publikováno v:
Diabetologia. 60:1442-1453
We aimed to investigate potential interactions between insulin and glucagon-like peptide (GLP)-1 signalling pathways in the regulation of beta cell-cycle dynamics in vivo, in the context of the therapeutic potential of GLP-1 to modulate impaired beta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eebdbdc738274635ffd4715ef7bcb3ff
https://doi.org/10.1007/s00125-017-4303-6
https://doi.org/10.1007/s00125-017-4303-6
Autor:
Siralee Munshi, Shari L. Caplan, Jinsheng Liang, Jiaping Gao, Bethany A Dale, Ramesh Chandra Gupta, Gregory Raymond Bebernitz, Michael Kavana, Brian Edward Vash, Paul Taslimi, Richard Deacon, Louise Kirman, Sunil Sadanand Nadkarni, Melissa S. Grondine, Valerie Beaulieu, Mesut Kakmak, Wieslawa Maniara, Irene St. Denny, Alokesh Duttaroy, Herbert F. Schuster, Travis Stams
Publikováno v:
Journal of Medicinal Chemistry. 52:6142-6152
Type 2 diabetes is a polygenic disease which afflicts nearly 200 million people worldwide and is expected to increase to near epidemic levels over the next 10-15 years. Glucokinase (GK) activators are currently under investigation by a number of phar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f42388d9d384fa55ff534be29a734c9
https://doi.org/10.1021/jm900839k
https://doi.org/10.1021/jm900839k
Autor:
Kathryn M.S. Johnson, Xia Zhang, Alan D. Cherrington, Alokesh Duttaroy, Dale S. Edgerton, Melanie Scott, C. H. Hobbs, Doss W. Neal
Publikováno v:
Diabetes
OBJECTIVE—This study investigated the acute effects of treatment with vildagliptin on dipeptidyl peptidase-4 (DPP-4) activity, glucagon-like peptide 1 (GLP-1) concentration, pancreatic hormone levels, and glucose metabolism. The primary aims were t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1ce89c163b4040e18d1f4791ebe6d39
https://doi.org/10.2337/db08-0515
https://doi.org/10.2337/db08-0515
Autor:
Dinesh Gautam, Sung-Jun Han, Christian Alzheimer, Chu-Xia Deng, Thomas Seeger, Yinghong Cui, Alokesh Duttaroy, Jürgen Wess
Publikováno v:
Journal of Molecular Neuroscience. 30:157-160
The five muscarinic acetylcholine receptors (M1-M5 mAChRs) mediate a very large number of important physiological functions (Caulfield, 1993; Caulfield and Birdsall, 1998; Wess, 2004). Because of the lack of small molecule ligands endowed with a high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41a6f0d888b694ba97fa58232038dab8
https://doi.org/10.1385/jmn:30:1:157
https://doi.org/10.1385/jmn:30:1:157
Autor:
Shashi Kaithamana, Melisa Carey-Barber, Kelly Murphy, Olivier Blondel, Thomas Kaufman, Malia A. McLean, Charles E. Birse, Oxana K. Pickeral, Robert Schulingkamp, Jana K. Siskind, Peter Reavey, Palanisamy Kanakaraj, Dan Crossan, Jason Bock, Andy Garcia, Susan Cheng, Mallika Singh, Blaire L. Osborn, Helmut Schneider, Surekha R. Krishnan, Steve Ruben, Alokesh Duttaroy, Cecil Chen, Guiyi Zhang
Publikováno v:
Diabetes. 54:251-258
The primary therapeutic goal for the treatment of diabetes is maintenance of a long-term, near-normoglycemic condition and prevention of the onset or progression of the complications associated with the disease. Although several analogs of human insu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d8a6fdf70c40d8c8b645ac9f998ab1d
https://doi.org/10.2337/diabetes.54.1.251
https://doi.org/10.2337/diabetes.54.1.251
Autor:
Charles E. Birse, Steve Ruben, Melisa C. Barber, Yanick Lazard, Ya-Qin Zhang, Carrie L. Fischer, Susan Cheng, Qinghai Zhao, Alokesh Duttaroy, Laurie Pukac, Linyi Zhang, Peter Reavey, Qi Wang, Lilin Zhong, Mallika Singh, Timothy A. Coleman, Steve Barash, Cecil Chen, Olivier Blondel, Krzysztof J. Grzegorzewski, Jon Hirsch, Indra Sanyal, Helmut Schneider, Roxanne Duan, Zhi-Dong Ma, Baiqin Teng, Adam Bell
Publikováno v:
Nature Biotechnology. 21:294-301
A coordinated functional genomics program was implemented to identify secreted polypeptides with therapeutic applications in the treatment of diabetes. Secreted factors were predicted from a diverse expressed-sequence tags (EST) database, representin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca226a899f2bebc47e1656e1a19af24
https://doi.org/10.1038/nbt795
https://doi.org/10.1038/nbt795
Autor:
Chu-Xia Deng, Kathryn G. Lamping, Yinghong Cui, Alokesh Duttaroy, Jiirgen Wess, Weilie Zhang, Frank M. Faraci, Jesus Gomeza, Masahisa Yamada, Tsuyoshi Miyakawa, L McKinzie, Frank P. Bymaster, C C Felder
Publikováno v:
Receptors and Channels. 9:279-290
A large body of evidence indicates that muscarinic acetylcholine receptors (mAChRs) play critical roles in regulating the activity of many important functions of the central and peripheral nervous systems. However, identification of the physiological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef31fd47612c43c9fa96e2119b755590
https://doi.org/10.3109/10606820308262
https://doi.org/10.3109/10606820308262
Autor:
Alokesh Duttaroy, W. Dean Harman, Nasir A. Siddiqui, Anthony S. Basile, Jesus Gomeza, Allan I. Levey, Christian C. Felder, Jai-Wei Gan, Jürgen Wess, Philip L. Smith
Publikováno v:
Molecular Pharmacology. 62:1084-1093
Centrally active muscarinic agonists display pronounced analgesic effects. Identification of the specific muscarinic acetylcholine receptor (mAChR) subtype(s) mediating this activity is of considerable therapeutic interest. To examine the roles of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f97a9e3b02177e3acc0b90b4fabce0
https://doi.org/10.1124/mol.62.5.1084
https://doi.org/10.1124/mol.62.5.1084
Autor:
Jürgen Wess, Alokesh Duttaroy, Kathryn G. Lamping, Christian C. Felder, Yinghong Cui, Chu-Xia Deng, Frank M. Faraci, Frank P. Bymaster, David L. McKinzie, Masahisa Yamada, Weilie Zhang
Publikováno v:
Proceedings of the National Academy of Sciences. 98:14096-14101
The M 5 muscarinic receptor is the most recent member of the muscarinic acetylcholine receptor family (M 1 -M 5 ) to be cloned. At present, the physiological relevance of this receptor subtype remains unknown, primarily because of its low expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f5d929294cb588a5c18079c631cdef
https://doi.org/10.1073/pnas.251542998
https://doi.org/10.1073/pnas.251542998
Autor:
Chieh J. Chou, Akihiro Yamanaka, Chu-Xia Deng, Masahisa Yamada, Tsuyoshi Miyakawa, Jacqueline N. Crawley, Christian C. Felder, Ryosuke Makita, Toru Moriguchi, Jürgen Wess, Alokesh Duttaroy, Masaharu Ogawa, Bing Xia
Publikováno v:
Nature. 410:207-212
Members of the muscarinic acetylcholine receptor family (M1-M5) have central roles in the regulation of many fundamental physiological functions. Identifying the specific receptor subtype(s) that mediate the diverse muscarinic actions of acetylcholin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f511e4f425b35020c785babfd67665e
https://doi.org/10.1038/35065604
https://doi.org/10.1038/35065604