Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Alokes, Majumdar"'
Publikováno v:
Critical Reviews in Biochemistry and Molecular Biology. 45:23-49
Interstrand DNA crosslinks (ICLs) are formed by natural products of metabolism and by chemotherapeutic reagents. Work in E. coli identified a two cycle repair scheme involving incisions on one strand on either side of the ICL (unhooking) producing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e036ed3de082d17b6207211ceed795
https://doi.org/10.3109/10409230903501819
https://doi.org/10.3109/10409230903501819
Autor:
Arun K. Thazhathveetil, Ji Lan Liu, Su Ting Liu, Paul S. Miller, Bernard Cuenoud, Alokes Majumdar, Michael M. Seidman, Shigeki Sasaki, Nitin Puri, Rowshon Alam
Publikováno v:
Biochemistry. 46:10222-10233
We are developing triple helix forming oligonucleotides (TFOs) for gene targeting. Previously, we synthesized bioactive TFOs containing 2'-O-methylribose (2'-OMe) and 2'-O-aminoethylribose (2'-AE) residues. Active TFOs contained four contiguous 2'-AE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bdf115494ae8aa829f1ec39c308f312
https://doi.org/10.1021/bi7003153
https://doi.org/10.1021/bi7003153
Autor:
Alokes Majumdar, Irène Ceballos-Picot, Mairead Kelly, Kiyoshi Egami, Thomas L. Shirley, Hyder A. Jinnah, J. Chris Lewers, Michael M. Seidman
Publikováno v:
Journal of Neurochemistry. 101:841-853
Mutations in the gene encoding the purine salvage enzyme, hypoxanthine-guanine phosphoribosyltransferase (HPRT) cause Lesch-Nyhan disease, a neurodevelopmental disorder characterized by cognitive, neurological, and behavioral abnormalities. Despite d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79cf6ba8a851b8213414579eed688421
https://doi.org/10.1111/j.1471-4159.2007.04472.x
https://doi.org/10.1111/j.1471-4159.2007.04472.x
Autor:
Alokes Majumdar, Su Ting Liu, Peter M. Glazer, Rowshon Alam, Bernard Cuenoud, Jean Y. Kuan, Paul S. Miller, Kazi Abdus Shahid, Xuifen Sui, Michael M. Seidman
Publikováno v:
Biochemistry. 45:1970-1978
Triple helix forming oligonucleotides (TFOs) may have utility as gene targeting reagents for "in situ" gene therapy of genetic disorders. Triplex formation is challenged by negative charge repulsion between third strand and duplex phosphates, and des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8121647b3e1dad071f9a4ce721ba9c9a
https://doi.org/10.1021/bi0520986
https://doi.org/10.1021/bi0520986
Autor:
Michael M. Seidman, Alokes Majumdar, Veronica Maher, Michel Bernier, Ji-Lan Liu, Sally Richards, Su-ting Liu, Rodney S. Nairn
Publikováno v:
Nucleic Acids Research
We have synthesized triple helix forming oligonucleotides (TFOs) that target a psoralen (pso) interstrand crosslink to a specific chromosomal site in mammalian cells. Mutagenesis of the targeted crosslinks results in base substitutions and deletions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2f95959a964af779c46247281f8d06
http://europepmc.org/articles/PMC1236719
http://europepmc.org/articles/PMC1236719
Autor:
Ji Lan Liu, Matthew D. Gray, Vilhelm A. Bohr, Michael M. Seidman, Alokes Majumdar, Jeanine A. Harrigan, Cayetano von Kobbe, E. Jeffery Metter, David M. Wilson
Publikováno v:
Mechanisms of Ageing and Development. 125:491-496
The leading causes of death for individuals with Werner syndrome (WS) are myocardial infarction (MI) and stroke. The WS gene encodes a nuclear protein with both helicase and exonuclease activities. While individuals with WS have mutations that result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f562829d79060536976536a5266c4ff
https://doi.org/10.1016/j.mad.2004.05.001
https://doi.org/10.1016/j.mad.2004.05.001
Autor:
Alokes Majumdar, Nicholas McCOLLUM, Sally Richards, Michael M. Seidman, Paul S. Miller, Nitin Puri, Bernard Cuenoud
Publikováno v:
Annals of the New York Academy of Sciences. 1002:141-153
Effective gene targeting reagents would have widespread utility for genomic manipulation including transgenic cell and animal construction and for gene therapy. They would also be useful in basic research as probes of chromatin structure, and as tool
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d249ecf3a914dc958daf43ba9b0304
https://doi.org/10.1196/annals.1281.013
https://doi.org/10.1196/annals.1281.013
Autor:
Pierre Martin, Bernard Cuenoud, Nitin Puri, Francois Natt, Alokes Majumdar, Paul S. Miller, Albert J. George, Michael M. Seidman, Alexander Khorlin, Natalia B. Dyatkina
Publikováno v:
Journal of Biological Chemistry. 278:11072-11077
Successful gene-targeting reagents must be functional under physiological conditions and must bind chromosomal target sequences embedded in chromatin. Triple helix-forming oligonucleotides (TFOs) recognize and bind specific sequences via the major gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b44ef07c4d28ac1e3fdd1a21cb0e0ed
https://doi.org/10.1074/jbc.m211837200
https://doi.org/10.1074/jbc.m211837200
Autor:
Nitin Puri, Pierre Martin, Paul S. Miller, Alokes Majumdar, Michael M. Seidman, Bernard Cuenoud, Andre Boyd, Francois Natt
Publikováno v:
Biochemistry. 41:7716-7724
Triple helix forming oligonucleotides (TFOs) that bind chromosomal targets in living cells may become tools for genome manipulation, including gene knockout, conversion, or recombination. However, triplex formation by DNA third strands, particularly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78943156665b848a4a7882c13b7dc61e
https://doi.org/10.1021/bi025734y
https://doi.org/10.1021/bi025734y
Autor:
Krystyna Lesiak, Stephen F. Carr, Marek Sochacki, Alokes Majumdar, Krzysztof W. Pankiewicz, Kyoichi A. Watanabe, Barry M. Goldstein, Andrzej Zatorski, Michael M. Seidman
Publikováno v:
Journal of Medicinal Chemistry. 40:1287-1291
beta-Methylene-BAD (8), a nonhydrolyzable analogue of benzamide adenine dinucleotide (BAD), was synthesized as potential inhibitor of human inosine monophosphate dehydrogenase (IMPDH). Treatment of 2',3'-O-isopropylideneadenosine 5'-methylenebisphosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c550e790bd07c95eb636f323258c5138
https://doi.org/10.1021/jm960641y
https://doi.org/10.1021/jm960641y