Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Alok V. Joglekar"'
Publikováno v:
Molecular Metabolism, Vol 78, Iss , Pp 101809- (2023)
Background: T1D is an autoimmune disease in which pancreatic islets of Langerhans are infiltrated by immune cells resulting in the specific destruction of insulin-producing islet beta cells. Our understanding of the factors leading to islet infiltrat
Externí odkaz:
https://doaj.org/article/739a8296cccc4b859cd972ef3d538867
Autor:
Caroline Y. Kuo, Joseph D. Long, Beatriz Campo-Fernandez, Satiro de Oliveira, Aaron R. Cooper, Zulema Romero, Megan D. Hoban, Alok V. Joglekar, Georgia R. Lill, Michael L. Kaufman, Sorel Fitz-Gibbon, Xiaoyan Wang, Roger P. Hollis, Donald B. Kohn
Publikováno v:
Cell Reports, Vol 23, Iss 9, Pp 2606-2616 (2018)
X-linked hyper-immunoglobulin M (hyper-IgM) syndrome (XHIM) is a primary immunodeficiency due to mutations in CD40 ligand that affect immunoglobulin class-switch recombination and somatic hypermutation. The disease is amenable to gene therapy using r
Externí odkaz:
https://doaj.org/article/a9f7ea463fcd4ac88ca63a2c49143223
Autor:
Javad Rahimikollu, Hanxi Xiao, Anna E. Rosengart, Tracy Tabib, Paul Zdinak, Kun He, Xin Bing, Florentina Bunea, Marten Wegkamp, Amanda C. Poholek, Alok V Joglekar, Robert A Lafyatis, Jishnu Das
Modern multi-omic technologies can generate deep multi-scale profiles. However, differences in data modalities, multicollinearity of the data, and large numbers of irrelevant features make the analyses and integration of high-dimensional omic dataset
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cec6bc44336b7a8ce433f6ebd5892e10
https://doi.org/10.1101/2022.11.25.518001
https://doi.org/10.1101/2022.11.25.518001
Autor:
Paul Zdinak, Stephanie Grebinoski, Jessica Torrey, Eduardo Zarate-Martinez, Louise Hicks, Rashi Ranjan, Nishtha Trivedi, Sanya Arshad, Mark Anderson, Dario AA Vignali, Alok V. Joglekar
CD4+ T cells recognize peptide antigens presented on class II Major Histocompatibility Complex (MHC-II) molecules to carry out their function. The remarkable diversity of T cell receptor (TCR) sequences and lack of antigen discovery approaches for MH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d019acb14b7542891872b9bc999dfbc5
https://doi.org/10.1101/2022.11.21.517373
https://doi.org/10.1101/2022.11.21.517373
Autor:
Mackenzie J. Bender, Alex C. McPherson, Catherine M. Phelps, Surya P. Pandey, Colin R. Laughlin, Jake H. Shapira, Luzmariel Medina Sanchez, Mohit Rana, Tanner G. Richie, Tahliyah S. Mims, Angela M. Gocher-Demske, Luisa Cervantes-Barragan, Steven J. Mullett, Stacy L. Gelhaus, Tullia C. Bruno, Nikki Cannon, John A. McCulloch, Dario A.A. Vignali, Reinhard Hinterleitner, Alok V. Joglekar, Joseph F. Pierre, Sonny T.M. Lee, Diwakar Davar, Hassane M. Zarour, Marlies Meisel
Publikováno v:
Cell. 186:1846-1862.e26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c602601337b3b15471cb1ee257b9d43
https://doi.org/10.1016/j.cell.2023.03.011
https://doi.org/10.1016/j.cell.2023.03.011
Autor:
Guideng Li, Alok V. Joglekar
Publikováno v:
Nature Methods. 18:873-880
T cells respond to threats in an antigen-specific manner using T cell receptors (TCRs) that recognize short peptide antigens presented on major histocompatibility complex (MHC) proteins. The TCR-peptide-MHC interaction mediated between a T cell and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52783c2b19d8845d613c3bb4420ca2df
https://doi.org/10.1038/s41592-020-0867-z
https://doi.org/10.1038/s41592-020-0867-z
Autor:
Margaret B. Swift, Jesse M. Zaretsky, Alok V. Joglekar, Michael T. Bethune, David Baltimore, Stephanie Wong, John D. Jeppson, Songming Peng, James R. Heath, Michael T. Leonard, Antoni Ribas, Guideng Li
Publikováno v:
Nature methods, vol 16, iss 2
Nature methods
Nature methods
CD8+ T cells recognize and eliminate tumors in an antigen-specific manner. Despite progress in characterizing the antitumor T cell repertoire and function, identifying their target antigens remains a challenge. Here, we describe the use of chimeric r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddde0c193708314b7132a967ac83d6a4
https://doi.org/10.1038/s41592-018-0304-8
https://doi.org/10.1038/s41592-018-0304-8
Autor:
Paul Zdinak, Stephanie J Grebinoski, Jessica Torrey, Sanjay Rathod, Rashi Ranjan, Louise Hicks, Alok V Joglekar
Publikováno v:
The Journal of Immunology. 208:104.05-104.05
Type 1 Diabetes (T1D) is an autoimmune disease caused by progressive destruction of pancreatic β-cells, resulting in reduced insulin production. The role of islet-infiltrating CD4+ T cells in mediating β-cell destruction and autoantibody formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c18df5dfa67ee8bcd1b3591a366a4976
https://doi.org/10.4049/jimmunol.208.supp.104.05
https://doi.org/10.4049/jimmunol.208.supp.104.05
Autor:
Godhev Kumar Manakkat Vijay, Kairavee Thakkar, Kashish Chetal, Stuart Hay, Jingyu Fan, Alok V Joglekar, Nathan Salomonis, Harinder Singh
Publikováno v:
The Journal of Immunology. 208:168.08-168.08
Plasma cell (PC) precursors are generated during a germinal center (GC) response and migrate to the bone marrow (BM) where they undergo terminal differentiation into short-lived (SL) or long-lived (LL) antibody secreting cells. The developmental dyna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01c9a8d40a4dbe0eac2763debf8f3377
https://doi.org/10.4049/jimmunol.208.supp.168.08
https://doi.org/10.4049/jimmunol.208.supp.168.08
Publikováno v:
RNA
At the heart of an innate immune response lies a tightly regulated gene expression program. This precise regulation is crucial because small changes can shift the balance from protective to destructive immunity. Here we identify a frequently used alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d700015130e03cb32486a242f3bb33
https://resolver.caltech.edu/CaltechAUTHORS:20191125-134707503
https://resolver.caltech.edu/CaltechAUTHORS:20191125-134707503