Výsledky vyhledávání - "Alok R. Singh"

Akademický článek

A Novel Affinity Engineered Anti-CD47 Antibody With Improved Therapeutic Index That Preserves Erythrocytes and Normal Immune Cells

Autor: Youg R. Thaker, Ianne Rivera, Christophe Pedros, Alok R. Singh, Laura Rivero-Nava, Heyue Zhou, Barbara A. Swanson, Lisa Kerwin, Yanliang Zhang, J. Dixon Gray, Gunnar F. Kaufmann, Henry Ji, Robert D. Allen, Damien Bresson

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Therapeutic blockade of the CD47/SIRPα axis by small molecules or monoclonal antibodies (mAbs) is a proven strategy to enhance macrophages-mediated anti-tumor activity. However, this strategy has been hampered by elevated on-target toxicities and ra

Externí odkaz: https://doaj.org/article/f2fd20b08a484f229820c4f813b7b3de

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Data from Single Agent and Synergistic Activity of the 'First-in-Class' Dual PI3K/BRD4 Inhibitor SF1126 with Sorafenib in Hepatocellular Carcinoma

Autor: Donald L. Durden, Guillermo A. Morales, Joseph R. Garlich, Yuko Kono, Sadakatsu Ikeda, Jason K. Sicklick, Adam M. Burgoyne, Shweta Joshi, Alok R. Singh

Deregulated PI3K/AKT/mTOR, Ras/Raf/MAPK, and c-Myc signaling pathways are of prognostic significance in hepatocellular carcinoma (HCC). Sorafenib, the only drug clinically approved for patients with advanced HCC, blocks the Ras/Raf/MAPK pathway but i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16e518a3ed05b07fda78e3134d0d6975
https://doi.org/10.1158/1535-7163.c.6538561.v1

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Supplementary Figure Legend from A Macrophage-Dominant PI3K Isoform Controls Hypoxia-Induced HIF1α and HIF2α Stability and Tumor Growth, Angiogenesis, and Metastasis

Autor: Donald L. Durden, Muamera Zulcic, Alok R. Singh, Shweta Joshi

Supplementary Figure Legend from A Macrophage-Dominant PI3K Isoform Controls Hypoxia-Induced HIF1α and HIF2α Stability and Tumor Growth, Angiogenesis, and Metastasis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4295afd77f35e423e479f11611130bb2
https://doi.org/10.1158/1541-7786.22514230.v1

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Fig. S2 from Single Agent and Synergistic Activity of the 'First-in-Class' Dual PI3K/BRD4 Inhibitor SF1126 with Sorafenib in Hepatocellular Carcinoma

Autor: Donald L. Durden, Guillermo A. Morales, Joseph R. Garlich, Yuko Kono, Sadakatsu Ikeda, Jason K. Sicklick, Adam M. Burgoyne, Shweta Joshi, Alok R. Singh

SF1126 and Sorafenib inhibit cell cycle progression by inducing apoptosis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03307a9deb77b1c3ff83e6d4c494c1fe
https://doi.org/10.1158/1535-7163.22507045.v1

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Supplementary Data from SF2523: Dual PI3K/BRD4 Inhibitor Blocks Tumor Immunosuppression and Promotes Adaptive Immune Responses in Cancer

Autor: Donald L. Durden, Joseph R. Garlich, Guillermo A. Morales, Christopher K. Glass, Hyun Bae Chun, Dylan Skola, Muamera Zulcic, Timothy V. Pham, Kevin X. Liu, Alok R. Singh, Shweta Joshi

File contains Supplementary Methods and References

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65ed2e16625c34228c62d32c2d601d92
https://doi.org/10.1158/1535-7163.22506045

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Supplementary Method from Single Agent and Synergistic Activity of the 'First-in-Class' Dual PI3K/BRD4 Inhibitor SF1126 with Sorafenib in Hepatocellular Carcinoma

Autor: Donald L. Durden, Guillermo A. Morales, Joseph R. Garlich, Yuko Kono, Sadakatsu Ikeda, Jason K. Sicklick, Adam M. Burgoyne, Shweta Joshi, Alok R. Singh

Contain description of Supplementary methods and legends to supplementary figures and tables

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d7ac18bfdf39c38027d8e16b71000e
https://doi.org/10.1158/1535-7163.22507042

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Supplementary Figures S1-S6 and Tables S1-S2 from SF2523: Dual PI3K/BRD4 Inhibitor Blocks Tumor Immunosuppression and Promotes Adaptive Immune Responses in Cancer

Autor: Donald L. Durden, Joseph R. Garlich, Guillermo A. Morales, Christopher K. Glass, Hyun Bae Chun, Dylan Skola, Muamera Zulcic, Timothy V. Pham, Kevin X. Liu, Alok R. Singh, Shweta Joshi

Supplementary Fig. S1 shows JQ1 blocks IL4 induced CD206 expression. Supplementary Fig. S2 shows Differentially expressed genes in LPS-stimulated or IL4 stimulated BMDMs. Supplementary Fig. S3 shows Effect of JQ1 on LLC tumor growth. Supplementary Fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2adac5ed436b48495ac221a346a90f80
https://doi.org/10.1158/1535-7163.22506042

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Table S1 from Single Agent and Synergistic Activity of the 'First-in-Class' Dual PI3K/BRD4 Inhibitor SF1126 with Sorafenib in Hepatocellular Carcinoma

Autor: Donald L. Durden, Guillermo A. Morales, Joseph R. Garlich, Yuko Kono, Sadakatsu Ikeda, Jason K. Sicklick, Adam M. Burgoyne, Shweta Joshi, Alok R. Singh

Chau Talalay Synergy studies on HCC cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ffa2adb3277e9f93c8f89eb7a21a132
https://doi.org/10.1158/1535-7163.22507039.v1

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Akademický článek

Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype.

Autor: Shweta Joshi, Alok R Singh, Simon S Wong, Muamera Zulcic, Min Jiang, Annie Pardo, Moises Selman, James S Hagood, Donald L Durden

Publikováno v: PLoS ONE, Vol 12, Iss 8, p e0182851 (2017)

Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by cellular phenotype alterations and deposition of extracellular matrix proteins. The alternative activation of macrophages in the lungs has been associated as a major facto

Externí odkaz: https://doaj.org/article/6c067b2716cc4e6b9d917aa70c083a3d

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Modular performance prediction for scientific workflows using Machine Learning

Autor: Alok R. Singh, Arvind Rao, Ilkay Altintas, Shweta Purawat

Publikováno v: Future Generation Computer Systems. 114:1-14

Scientific workflows provide an opportunity for declarative computational experiment design in an intuitive and efficient way. A distributed workflow is typically executed on a variety of resources, and it uses a variety of computational algorithms o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64ae2a0ab41b0231138b3b9e83a300a8
https://doi.org/10.1016/j.future.2020.04.048

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