Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Alok Pachori"'
Autor:
Umberto Vitolo, Grzegorz S. Nowakowski, John M. Burke, Christopher P. Fox, Marek Trneny, Annalisa Chiappella, Maeve Waldron-Lynch, Steve Wagner, Alok Pachori, Georg Lenz
Publikováno v:
Blood. 140:6618-6620
Autor:
Steven R. Smith, Christopher Bock, Alok Pachori, Joshua S Smith, Stephanie A. Parsons, Stephen J. Gardell, Fanchao Yi, Christopher Petucci, Karen P. Jones, Katie L Whytock, Hui Xie, Karen D. Corbin
Publikováno v:
The American Journal of Clinical Nutrition. 114:267-280
BACKGROUND Low-calorie diet (LCD)-induced weight loss demonstrates response heterogeneity. Physiologically, a decrease in energy expenditure lower than what is predicted based on body composition (metabolic adaptation) and/or an impaired capacity to
Autor:
Stephen A. Harrison, Federico Perez Manghi, William B. Smith, Diana Alpenidze, Diego Aizenberg, Naomi Klarenbeek, Chi-Yi Chen, Eli Zuckerman, Eric Ravussin, Phunchai Charatcharoenwitthaya, Pin-Nan Cheng, Helena Katchman, Samuel Klein, Ziv Ben-Ari, Anisha E. Mendonza, Yiming Zhang, Miljen Martic, Shenglin Ma, Sheena Kao, Sandra Tanner, Alok Pachori, Michael K. Badman, YanLing He, Chinweike Ukomadu, Eric Sicard
Publikováno v:
Nat Med
Nonalcoholic steatohepatitis (NASH) is a common chronic liver disease that may advance to fibrosis and lead to mortality; however, no pharmacotherapy is currently available. We tested the hypothesis that inhibition of both the sodium-glucose cotransp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e75d88194984d7468a9e9fe7ccab93e
https://europepmc.org/articles/PMC10061496/
https://europepmc.org/articles/PMC10061496/
Autor:
Umberto Vitolo, Grzegorz S. Nowakowski, John M. Burke, Christopher P. Fox, Marek Trneny, Annalisa Chiappella, Maeve Waldron-Lynch, Nira Hadar, Alok Pachori, Georg Lenz
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 22:S352-S353
Autor:
Paul Rolzin, Jennifer Matuszkiewicz, James Bilakovics, Alok Pachori, Christopher J. Zopf, Pamela Farrell, Huey-Jing Huang, Artur Plonowski, Urmi Banerjee, Andrea Fanjul, Christopher McBride, Christopher J. Larson, Corine Holub, Zacharia Cheruvallath, Jacques Ermolieff, Darian Bartkowski, Crystal Mazur, Deepika Balakrishna
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 371:299-308
Target-engagement pharmacodynamic (PD) biomarkers are valuable tools in the prioritization of drug candidates, especially for novel, first-in-class mechanisms whose robustness to alter disease outcome is unknown. Methionine aminopeptidase 2 (MetAP2)
Autor:
Umberto Vitolo, Grzegorz S. Nowakowski, John M. Burke, Christopher P. Fox, Marek Trneny, Annalisa Chiappella, Maeve Waldron-Lynch, Nira Hadar, Alok Pachori, Georg Lenz
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 22:S163
Autor:
Umberto Vitolo, Grzegorz S. Nowakowski, John M. Burke, Christopher P. Fox, Marek Trneny, Annalisa Chiappella, Maeve Waldron-Lynch, Nira Hadar, Alok Pachori, Georg Lenz
Publikováno v:
Journal of Clinical Oncology. 40:TPS7590-TPS7590
TPS7590 Background: Up to 40% of patients relapse or are refractory (R/R) to R-CHOP, the current standard of care for diffuse large B-cell lymphoma (DLBCL), indicating an unmet need, particularly in patients with high-intermediate and high-risk disea
Autor:
Shola Richards, Florian Nigsch, Anna Baiges, Nancy Finkel, Alok Pachori, Sabela Lens, Dale Mongeon, Yiming Zhang, Fanny Turon, José Ferrusquia, Michel Blé Caso, Marta Magaz, Xavier Forns, Chinweike Ukomadu, Virginia Hernandez-Gea, Juan Carlos Garcia Pagan
Publikováno v:
Journal of Hepatology. 73:S786-S787
Autor:
Parag Garhyan, Richard E. Pratley, Niels Porksen, Helle Linnebjerg, Steven R. Smith, Eric Chen Quin Lam, Alok Pachori
Publikováno v:
Diabetes, obesitymetabolism. 20(5)
Aims When treated with basal insulin peglispro (BIL), patients with type 1 diabetes mellitus (T1DM) exhibit weight loss and lower prandial insulin requirements versus insulin glargine (GL), while total insulin requirements remain similar. One possibl
Autor:
Susan Khan, Yangbo Feng, Alok Pachori, Thomas Schröter, Yan Yin, Jennifer Pocas, Li Lin, Philip LoGrasso, Yen Ting Chen, Michael D. Cameron, Stephan C. Schürer, Wayne Grant
Publikováno v:
ACS medicinal chemistry letters. 1(4)
A series of urea-based Rho kinase (ROCK) inhibitors were designed and evaluated. The discovered compounds had excellent enzyme and cellular potency, high kinase selectivity, high aqueous solubility, good porcine corneal penetration, and appropriate D