Trop-2, Na ⁺ /K ⁺ ATPase, CD9, PKCα, cofilin assemble a membrane signaling super-complex that drives colorectal cancer growth and invasion.

Autor: Guerra E; Laboratory of Cancer Pathology, Center for Advanced Studies and Technology (CAST), University 'G. D'Annunzio', Chieti, Italy.; Department of Medical, Oral and Biotechnological Sciences, University 'G. D'Annunzio', Chieti, Italy., Relli V; Laboratory of Cancer Pathology, Center for Advanced Studies and Technology (CAST), University 'G. D'Annunzio', Chieti, Italy., Ceci M; Laboratory of Cancer Pathology, Center for Advanced Studies and Technology (CAST), University 'G. D'Annunzio', Chieti, Italy., Tripaldi R; Laboratory of Cancer Pathology, Center for Advanced Studies and Technology (CAST), University 'G. D'Annunzio', Chieti, Italy., Simeone P; Laboratory of Cancer Pathology, Center for Advanced Studies and Technology (CAST), University 'G. D'Annunzio', Chieti, Italy.; Department of Medicine and Aging Sciences, University 'G. D'Annunzio', Chieti, Italy.; Laboratory of Cytomorphology, Center for Advanced Studies and Technology (CAST), University 'G. D'Annunzio', Chieti, Italy., Aloisi AL; Laboratory of Cancer Pathology, Center for Advanced Studies and Technology (CAST), University 'G. D'Annunzio', Chieti, Italy., Pantalone L; Laboratory of Cancer Pathology, Center for Advanced Studies and Technology (CAST), University 'G. D'Annunzio', Chieti, Italy., La Sorda R; Laboratory of Cancer Pathology, Center for Advanced Studies and Technology (CAST), University 'G. D'Annunzio', Chieti, Italy., Lattanzio R; Laboratory of Cancer Pathology, Center for Advanced Studies and Technology (CAST), University 'G. D'Annunzio', Chieti, Italy.; Department of Innovative Technologies in Medicine & Dentistry, University 'G.D'Annunzio', Chieti, Italy., Sacchetti A; Laboratory of Cancer Pathology, Center for Advanced Studies and Technology (CAST), University 'G. D'Annunzio', Chieti, Italy.; Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands., Havas K; Laboratory of Cancer Pathology, Center for Advanced Studies and Technology (CAST), University 'G. D'Annunzio', Chieti, Italy.; FIRC Institute of Molecular Oncology (IFOM), Milan, Italy., Guarnieri S; Laboratory of Cell Physiology, Center for Advanced Studies and Technology (CAST), University 'G. D'Annunzio', Chieti, Italy.; Department of Neuroscience, Imaging and Clinical Sciences, University 'G. D'Annunzio', Chieti, Italy., Vergara D; Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy., Fournier I; Inserm U-1192, Laboratoire de Protéomique, Réponse Inflammatoire, Spectrométrie de Masse, Université de Lille 1, Cité Scientifique, Villeneuve D'Ascq Cedex, France., Salzet M; Inserm U-1192, Laboratoire de Protéomique, Réponse Inflammatoire, Spectrométrie de Masse, Université de Lille 1, Cité Scientifique, Villeneuve D'Ascq Cedex, France., Tinari N; Department of Medical, Oral and Biotechnological Sciences, University 'G. D'Annunzio', Chieti, Italy., Piantelli M; Laboratory of Cancer Pathology, Center for Advanced Studies and Technology (CAST), University 'G. D'Annunzio', Chieti, Italy.; Department of Medical, Oral and Biotechnological Sciences, University 'G. D'Annunzio', Chieti, Italy., Trerotola M; Laboratory of Cancer Pathology, Center for Advanced Studies and Technology (CAST), University 'G. D'Annunzio', Chieti, Italy. marco.trerotola@unich.it.; Department of Medical, Oral and Biotechnological Sciences, University 'G. D'Annunzio', Chieti, Italy. marco.trerotola@unich.it., Alberti S; Laboratory of Cancer Pathology, Center for Advanced Studies and Technology (CAST), University 'G. D'Annunzio', Chieti, Italy. salberti@unime.it.; Unit of Medical Genetics, Department of Biomedical Sciences, University of Messina, Messina, Italy. salberti@unime.it.

Publikováno v: Oncogene [Oncogene] 2022 Mar; Vol. 41 (12), pp. 1795-1808. Date of Electronic Publication: 2022 Feb 07.

The Tumor-Associated Calcium Signal Transducer 2 (TACSTD2) oncogene is upregulated in cystic epithelial cells revealing a potential new target for polycystic kidney disease.

Autor: Smith, Abigail O.^1,2 (AUTHOR), Frantz, William Tyler^1,2 (AUTHOR), Preval, Kenley M.^1,2 (AUTHOR), Edwards, Yvonne J. K.¹ (AUTHOR), Ceol, Craig J.¹ (AUTHOR), Jonassen, Julie A.³ (AUTHOR), Pazour, Gregory J.¹ (AUTHOR) gregory.pazour@umassmed.edu

Publikováno v: PLoS Genetics. 12/12/2024, Vol. 20 Issue 12, p1-23. 23p.

Updated clinical evidence and molecular features of antibody-drug conjugates for advanced urothelial carcinoma.

Autor: Wang, Ching-Yun¹ (AUTHOR), Teng, Pai-Chi^2,3 (AUTHOR), Hong, Jian-Hua^3,4 (AUTHOR) d07528012@ntu.edu.tw

Publikováno v: Urological Science. Sep2024, Vol. 35 Issue 3, p103-111. 9p.

Trop-2 Induces Tumor Growth Through AKT and Determines Sensitivity to AKT Inhibitors.

Autor: Guerra E; Unit of Cancer Pathology, CeSI-MeT, University 'G. d'Annunzio,' Chieti, Italy., Trerotola M; Unit of Cancer Pathology, CeSI-MeT, University 'G. d'Annunzio,' Chieti, Italy., Tripaldi R; Unit of Cancer Pathology, CeSI-MeT, University 'G. d'Annunzio,' Chieti, Italy., Aloisi AL; Unit of Cancer Pathology, CeSI-MeT, University 'G. d'Annunzio,' Chieti, Italy., Simeone P; Unit of Cancer Pathology, CeSI-MeT, University 'G. d'Annunzio,' Chieti, Italy., Sacchetti A; Unit of Cancer Pathology, CeSI-MeT, University 'G. d'Annunzio,' Chieti, Italy., Relli V; Unit of Cancer Pathology, CeSI-MeT, University 'G. d'Annunzio,' Chieti, Italy., D'Amore A; Unit of Cancer Pathology, CeSI-MeT, University 'G. d'Annunzio,' Chieti, Italy., La Sorda R; Unit of Cancer Pathology, CeSI-MeT, University 'G. d'Annunzio,' Chieti, Italy., Lattanzio R; Unit of Cancer Pathology, CeSI-MeT, University 'G. d'Annunzio,' Chieti, Italy. Department of Medical, Oral and Biotechnological Sciences, University 'G. d'Annunzio,' Chieti, Italy., Piantelli M; Unit of Cancer Pathology, CeSI-MeT, University 'G. d'Annunzio,' Chieti, Italy. Department of Medical, Oral and Biotechnological Sciences, University 'G. d'Annunzio,' Chieti, Italy., Alberti S; Unit of Cancer Pathology, CeSI-MeT, University 'G. d'Annunzio,' Chieti, Italy. Department of Neuroscience, Imaging and Clinical Sciences, Unit of Physiology and Physiopathology, University 'G. d'Annunzio,' Chieti, Italy. s.alberti@unich.it.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2016 Aug 15; Vol. 22 (16), pp. 4197-205. Date of Electronic Publication: 2016 Mar 28.

Advances in Trop-2 targeted antibody-drug conjugates for breast cancer: mechanisms, clinical applications, and future directions.

Autor: Tong, Yujun, Fan, Xiaobing, Liu, Huan, Liang, Tiantian

Publikováno v: Frontiers in Immunology; 2024, p1-18, 18p