Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Alois Kozubik"'
Autor:
Pavel Krejci, Anie Aklian, Marketa Kaucka, Eva Sevcikova, Jirina Prochazkova, Jan Kukla Masek, Pavol Mikolka, Tereza Pospisilova, Tereza Spoustova, MaryAnn Weis, William A Paznekas, Joshua H Wolf, J Silvio Gutkind, William R Wilcox, Alois Kozubik, Ethylin Wang Jabs, Vitezslav Bryja, Lisa Salazar, Iva Vesela, Lukas Balek
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35826 (2012)
Receptor tyrosine kinase signaling cooperates with WNT/β-catenin signaling in regulating many biological processes, but the mechanisms of their interaction remain poorly defined. We describe a potent activation of WNT/β-catenin by FGFR2, FGFR3, EGF
Externí odkaz:
https://doaj.org/article/c0182a0e9b1847789602f32735b60daf
Autor:
Pavel Krejci, Lisa Salazar, Tamara A Kashiwada, Katarina Chlebova, Alena Salasova, Leslie Michels Thompson, Vitezslav Bryja, Alois Kozubik, William R Wilcox
Publikováno v:
PLoS ONE, Vol 3, Iss 12, p e3961 (2008)
Activating mutations in FGFR3 tyrosine kinase cause several forms of human skeletal dysplasia. Although the mechanisms of FGFR3 action in cartilage are not completely understood, it is believed that the STAT1 transcription factor plays a central role
Externí odkaz:
https://doaj.org/article/05d9a687bded42dbbc7fcef01db7e7b0
Autor:
Vitezslav Bryja, Sarka Pavlova, Sarka Pospisilova, Alois Kozubik, Sivasubramanian Baskar, Michaela Machalova, Michael Doubek, Yvona Brychtova, Olga Stehlikova, Marek Borsky, Michaela Hlozkova, Petra Ovesna, Marketa Kaucka, Martin Behal, Hana Plesingerova, Karla Plevova, Lucie Poppova, Pavlina Janovska
Supplementary Figures 1-6. Supplementary Fig. 1: ROR1 mRNA expression determined by qRT-PCR correlates with the amount of the surface receptor present on primary CLL cells. Supplementary Fig. 2: Expression of ROR1 in the WNT5A-negative and WNT5Aposit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71815bf73bd4150f12de2feb302fa99f
https://doi.org/10.1158/1078-0432.22459512
https://doi.org/10.1158/1078-0432.22459512
Autor:
Vitezslav Bryja, Sarka Pavlova, Sarka Pospisilova, Alois Kozubik, Sivasubramanian Baskar, Michaela Machalova, Michael Doubek, Yvona Brychtova, Olga Stehlikova, Marek Borsky, Michaela Hlozkova, Petra Ovesna, Marketa Kaucka, Martin Behal, Hana Plesingerova, Karla Plevova, Lucie Poppova, Pavlina Janovska
Purpose: ROR1, a receptor in the noncanonical Wnt/planar cell polarity (PCP) pathway, is upregulated in malignant B cells of chronic lymphocytic leukemia (CLL) patients. It has been shown that the Wnt/PCP pathway drives pathogenesis of CLL, but which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6229dd060004ef37f6b03258d4975679
https://doi.org/10.1158/1078-0432.c.6524235.v1
https://doi.org/10.1158/1078-0432.c.6524235.v1
Autor:
Jiřina Hofmanová, Josef Slavík, Petra Ovesná, Zuzana Tylichová, Ladislav Dušek, Nicol Straková, Alena Hyršlová Vaculová, Miroslav Ciganek, Zdeněk Kala, Miroslav Jíra, Igor Penka, Jitka Kyclová, Zdeněk Kolář, Alois Kozubík, Miroslav Machala, Jan Vondráček
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0228010 (2020)
Identification of changes of phospholipid (PL) composition occurring during colorectal cancer (CRC) development may help us to better understand their roles in CRC cells. Here, we used LC-MS/MS-based PL profiling of cell lines derived from normal col
Externí odkaz:
https://doaj.org/article/d3d02b79a03c480989e24cf94b55ad2e
Autor:
Jarmila Herůdková, Kamil Paruch, Prashant Khirsariya, Karel Souček, Martin Krkoška, Olga Vondálová Blanářová, Petr Sova, Alois Kozubík, Alena Hyršlová Vaculová
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 10, Pp 830-841 (2017)
Although Chk1 kinase inhibitors are currently under clinical investigation as effective cancer cell sensitizers to the cytotoxic effects of numerous chemotherapeutics, there is still a considerable uncertainty regarding their role in modulation of an
Externí odkaz:
https://doaj.org/article/e81b0f5a2c1d4cceb65c2243075f3a24
Autor:
Jiřina Hofmanová, Josef Slavík, Miroslav Ciganek, Petra Ovesná, Zuzana Tylichová, Martina Karasová, Ondřej Zapletal, Nicol Straková, Jiřina Procházková, Jan Bouchal, Zdeněk Kolář, Jiří Ehrmann, Monika Levková, Zlatka Hušková, Pavel Skalický, Alois Kozubík, Miroslav Machala, Jan Vondráček
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13, p 6650 (2021)
The development of colon cancer, one of the most common malignancies, is accompanied with numerous lipid alterations. However, analyses of whole tumor samples may not always provide an accurate description of specific changes occurring directly in tu
Externí odkaz:
https://doaj.org/article/d72a2e38df374328a61dd8cc467d11d4
Autor:
Olga Vondálová Blanářová, Barbora Šafaříková, Jarmila Herůdková, Martin Krkoška, Silvie Tománková, Zuzana Kahounová, Ladislav Anděra, Jan Bouchal, Gvantsa Kharaishvili, Milan Král, Petr Sova, Alois Kozubík, Alena Hyršlová Vaculová
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188584 (2017)
Searching for new strategies for effective elimination of human prostate cancer cells, we investigated the cooperative cytotoxic action of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and two platinum-based complexes, cisplatin or
Externí odkaz:
https://doaj.org/article/f28d4460e94e49e89d81127c542aa443
Autor:
Zuzana Pernicová, Eva Slabáková, Gvantsa Kharaishvili, Jan Bouchal, Milan Král, Zuzana Kunická, Miroslav Machala, Alois Kozubík, Karel Součcek
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 6, Pp 526-536 (2011)
Although the induction of senescence in cancer cells is a potent mechanism of tumor suppression, senescent cells remain metabolically active and may secrete a broad spectrum of factors that promote tumorigenicity in neighboring malignant cells. Here
Externí odkaz:
https://doaj.org/article/95315d1ad9da43b48a4b6e251a65d3ae
Autor:
Jarmila Lauková, Alois Kozubík, Jiřina Hofmanová, Jana Nekvindová, Petr Sova, Mary Pat Moyer, Jiří Ehrmann, Alena Hyršlová Vaculová
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141020 (2015)
We demonstrated for the first time an outstanding ability of rosiglitazone to mediate a profound enhancement of LA-12-induced apoptosis associated with activation of mitochondrial pathway in human colon cancer cells. This effect was preferentially ob
Externí odkaz:
https://doaj.org/article/e9e52676bb104a499fa76dc88f32d583