Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Alnespirone"'
Autor:
Elizabeth Mocaer, Patricia Schmitt, Bernard Renaud, Michel Hamon, C. M. Fattaccini, Christophe Dugast, Francesc Artigas, Guy Chouvet, Josep Casanovas, Monique Lesourd, Fabienne Soulière
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
The effects of the new methoxy-chroman 5-HT1A receptor agonist, alnespirone (S-20499), on the dopamine systems in the rat brain were assessed in vivo by means of electrophysiological and neurochemical techniques. Cumulative doses of alnespirone (0.03
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98b6243c764647ad7b91897357568e6c
https://doi.org/10.1016/s0014-2999(98)00254-4
https://doi.org/10.1016/s0014-2999(98)00254-4
Publikováno v:
Psychopharmacology. 167:145-152
Increased alcohol intake after administration of low doses of 5-HT(1A )agonists is thought to be due to a reduction in 5-HT impulse flow due to activation of 5-HT(1A) somatodendritic receptors, whereas decreased alcohol drinking found after administr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a65bae8389a3bd4900ff7658ad46f5c4
https://doi.org/10.1007/s00213-003-1395-0
https://doi.org/10.1007/s00213-003-1395-0
Autor:
Bea J. van der Vegt, Luis Moya-Albiol, Katsunori Kato, Natasja Lieuwes, Esther H.E.M. van de Wall, Jaap M. Koolhaas, Sonia Martínez-Sanchis, Sietse F. de Boer
Publikováno v:
Behavioral Neuroscience, 117(4), 667-674
Behavioral Neuroscience, 117, 4, pp. 667-74
Behavioral Neuroscience, 117, 667-74
Behavioral Neuroscience, 117, 4, pp. 667-74
Behavioral Neuroscience, 117, 667-74
Item does not contain fulltext High aggression is often linked to lowered serotonin (5-HT) neurotransmission. Although this may hold for high aggression as a trait characteristic of an individual, serotonergic activity is probably increased during pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1113eafe7e273580c3adb9b51b0c6d5
https://hdl.handle.net/2066/184862
https://hdl.handle.net/2066/184862
Autor:
Mariusz Papp, Carmen Muñoz
Publikováno v:
Pharmacology Biochemistry and Behavior. 63:647-653
A chronic mild stress (CMS) model of depression was used to study an antidepressant-like activity of alnespirone (S 20499), a selective agonist of 5-HT1A receptors. In this model, a substantial decrease in consumption of a palatable sucrose solution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6bd4a539c8841c40f50ac72082c236
https://doi.org/10.1016/s0091-3057(99)00031-3
https://doi.org/10.1016/s0091-3057(99)00031-3
Publikováno v:
Neuropharmacology. 38:525-532
In line with the idea that cholecystokinin (CCK) is involved in anxiety-related behaviours, previous investigations showed that stressful conditions and an 'anxiogenic' drug, yohimbine, increased the cortical release of CCK like-material (CCKLM) in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29bfe4ec02772dc25c566d932d7ea698
https://doi.org/10.1016/s0028-3908(98)00209-3
https://doi.org/10.1016/s0028-3908(98)00209-3
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Single treatment with the serotonin (5-hydroxytryptamine) 5-HT1A receptor agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and alnespirone (S-20499) reduces the extracellular 5-HT concentration (5-HText) in the rat midbrain and forebrain.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5d9c4bab18d218474b025a79289abc
https://doi.org/10.1046/j.1471-4159.1999.0720262.x
https://doi.org/10.1046/j.1471-4159.1999.0720262.x
Autor:
Elisabeth Mocaer, N Laaris, Laurence Lanfumey, Emmanuel Le Poul, Claude-Michèle Fattaccini, Michel Hamon, E. Doucet
Publikováno v:
European Journal of Pharmacology. 365:165-173
The effects of long-term (7, 14 or 21 days) administration of the 5-HT1A receptor agonist alnespirone [5 mg/(kg day), i.p.] on the binding characteristics of 5-HT1A, 5-HT2A and 5-HT3 receptors, and the functional status of 5-HT1A autoreceptors were a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbc6c580f3931511ce35e9387cce5200
https://doi.org/10.1016/s0014-2999(98)00886-3
https://doi.org/10.1016/s0014-2999(98)00886-3
Publikováno v:
Pharmacology Biochemistry and Behavior. 60:677-683
VAN DE KAR, L. D., A. D. LEVY, Q. LI AND M. S. BROWNFIELD. A comparison of the oxytocin and vasopressin responses to the 5-HT1A agonist and potential anxiolytic drug alnespirone (S-20499). PHARMACOL BIOCHEM BEHAV 60(3) 677–683, 1998.—The effect o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4b42906206c593e23ef796f6adbc73
https://doi.org/10.1016/s0091-3057(98)00025-2
https://doi.org/10.1016/s0091-3057(98)00025-2
Publikováno v:
British Journal of Pharmacology. 122:733-741
1 We have examined the effects of the systemic administration of the selective 5-HT1A agonist alnespirone (S-20499) on in vivo 5-hydroxytryptamine (5-HT) release in the dorsal raphe nucleus, the median raphe nucleus and four forebrain areas innervate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7005343e93c4a1aeb3284c8ce3bb2180
https://doi.org/10.1038/sj.bjp.0701420
https://doi.org/10.1038/sj.bjp.0701420
Publikováno v:
European Journal of Pharmacology. 337:297-308
Determination of the optimal assay conditions for the specific binding of a tritiated derivative of the novel potential anxiolytic drug alnespirone (S-20499, (+)-4-[N-(5-methoxy-chroman-3-yl)-N-propylamino]butyl-8-azaspiro-(4,5)-decane-7,9-dione) all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::815954253e20333dc52534b332e0e4e9
https://doi.org/10.1016/s0014-2999(97)01288-0
https://doi.org/10.1016/s0014-2999(97)01288-0