Zobrazeno 1 - 10
of 353
pro vyhledávání: '"Alnawaz Rehemtulla"'
Autor:
Cooper M. Stansbury, Gabrielle A. Dotson, Harrison Pugh, Alnawaz Rehemtulla, Indika Rajapakse, Lindsey A. Muir
Publikováno v:
JCI Insight, Vol 8, Iss 19 (2023)
Adipose tissue macrophage (ATM) infiltration is associated with adipose tissue dysfunction and insulin resistance in mice and humans. Recent single-cell data highlight increased ATM heterogeneity in obesity but do not provide a spatial context for AT
Externí odkaz:
https://doaj.org/article/b0eea1834ac746279936bdccf695f8e6
Autor:
Sundaresh Ram, Wenfei Tang, Alexander J. Bell, Ravi Pal, Cara Spencer, Alexander Buschhaus, Charles R. Hatt, Marina Pasca diMagliano, Alnawaz Rehemtulla, Jeffrey J. Rodríguez, Stefanie Galban, Craig J. Galban
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 42, Iss , Pp 100911- (2023)
Early detection of lung cancer is critical for improvement of patient survival. To address the clinical need for efficacious treatments, genetically engineered mouse models (GEMM) have become integral in identifying and evaluating the molecular under
Externí odkaz:
https://doaj.org/article/460f7e89aaaa4281be99afd45042a8d2
Autor:
Wajd N. Al-Holou, Hanxiao Wang, Visweswaran Ravikumar, Sunita Shankar, Morgan Oneka, Ziad Fehmi, Roel GW Verhaak, Hoon Kim, Drew Pratt, Sandra Camelo-Piragua, Corey Speers, Daniel R Wahl, Todd Hollon, Oren Sagher, Jason A Heth, Karin M. Muraszko, Theodore S. Lawrence, Ana C de Carvalho, Tom Mikkelsen, Arvind Rao, Alnawaz Rehemtulla
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 36, Iss , Pp 100872- (2023)
Purpose: Glioblastoma(GBM) is a lethal disease characterized by inevitable recurrence. Here we investigate the molecular pathways mediating resistance, with the goal of identifying novel therapeutic opportunities. Experimental design: We developed a
Externí odkaz:
https://doaj.org/article/a0132180ec4b462dbadc5529f928818b
Autor:
Ren Wang, Tianqi Chen, Stephen M. Lindsly, Cooper M. Stansbury, Alnawaz Rehemtulla, Indika Rajapakse, Alfred O. Hero
Publikováno v:
IEEE Access, Vol 10, Pp 22061-22078 (2022)
Adversarial attacks against deep neural networks (DNNs) are continuously evolving, requiring increasingly powerful defense strategies. We develop a novel adversarial defense framework inspired by the adaptive immune system: the Robust Adversarial Imm
Externí odkaz:
https://doaj.org/article/d6f8dc4f089741988445eee6941b25d1
Autor:
Yinghua Li, Bo Li, Wei Li, Yuan Wang, Seçkin Akgül, Daniel M. Treisman, Kevin A. Heist, Brianna R. Pierce, Benjamin Hoff, Cheng-Ying Ho, David O. Ferguson, Alnawaz Rehemtulla, Siyuan Zheng, Brian D. Ross, Jun Z. Li, Yuan Zhu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Recent studies suggest spatial segregation of tumor initiation and manifestation in IDH-WT glioblastomas. Here, the authors use serial MRI/3D-reconstruction, whole-genome sequencing and spectral karyotyping-based single-cell phylogenetic tree buildin
Externí odkaz:
https://doaj.org/article/4bdb60bfd8b842efb554542d31c8e854
Autor:
Shyam Nyati, Brandon S. Gregg, Jiaqi Xu, Grant Young, Lauren Kimmel, Mukesh K. Nyati, Dipankar Ray, Corey Speers, Alnawaz Rehemtulla
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 4, Pp 163-178 (2020)
BUB1 (budding uninhibited by benzimidazoles-1) is required for efficient TGF-β signaling, through its role in stabilizing the TGFBR1 and TGFBR2 complex. Here we demonstrate that TGFBR2 phosphorylates BUB1 at Serine-318, which is conserved in primate
Externí odkaz:
https://doaj.org/article/15ddb17817d04f17a196bc1e17d92b72
Autor:
Stephen Lindsly, Wenlong Jia, Haiming Chen, Sijia Liu, Scott Ronquist, Can Chen, Xingzhao Wen, Cooper Stansbury, Gabrielle A. Dotson, Charles Ryan, Alnawaz Rehemtulla, Gilbert S. Omenn, Max Wicha, Shuai Cheng Li, Lindsey Muir, Indika Rajapakse
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103452- (2021)
Summary: Every human somatic cell inherits a maternal and a paternal genome, which work together to give rise to cellular phenotypes. However, the allele-specific relationship between gene expression and genome structure through the cell cycle is lar
Externí odkaz:
https://doaj.org/article/1464b2f0f40c401fb323e8020e9122d5
Autor:
Ibrahim Oraiqat, Samuel DeBruin, Robin Pearce, Christopher Como, Justin Mikell, Charles Taylor, John Way, Manuel Suarez, Alnawaz Rehemtulla, Roy Clarke, Issam El Naqa
Publikováno v:
IEEE Photonics Journal, Vol 11, Iss 4, Pp 1-16 (2019)
Cerenkov Emission (CE) during external beam radiation therapy (EBRT) from a linear accelerator (Linac) has been demonstrated as a useful tool for radiotherapy quality assurance and potentially other applications for online tracking of tumors during t
Externí odkaz:
https://doaj.org/article/045272512b7b4653b49b07fe377ee60d
Autor:
Ibrahim Oraiqat, Essam Al-Snayyan, Andrew Calcaterra, Roy Clarke, Alnawaz Rehemtulla, Issam El Naqa
Publikováno v:
Frontiers in Physics, Vol 9 (2021)
Cerenkov Emission (CE) multispectral analysis with silicon photomultiplier (SiPM)-based optical probes is a promising tool for online tumor microenvironment interrogation and targeting during radiotherapy delivery. With the extreme sensitivity of SiP
Externí odkaz:
https://doaj.org/article/8ac04be23624470fa3cb3debbaee1488
Autor:
Yajing Liu, Sahezeel Awadia, Amy Delaney, Merna Sitto, Carl G. Engelke, Heli Patel, Andrew Calcaterra, Sylvia Zelenka-Wang, Hojin Lee, Joseph Contessa, Nouri Neamati, Mats Ljungman, Theodore S. Lawrence, Meredith A. Morgan, Alnawaz Rehemtulla
Publikováno v:
Translational Oncology, Vol 13, Iss 11, Pp 100834- (2020)
The Unfolded Protein Response (UPR) plays a key role in the adaptive response to loss of protein homeostasis within the endoplasmic reticulum (ER). The UPR has an adaptive function in protein homeostasis, however, sustained activation of the UPR due
Externí odkaz:
https://doaj.org/article/8565fd736ec64fb4919739945b14f89d