Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Almut Schulze"'
Autor:
Tal Levy, Kai Voeltzke, Laura Hruby, Khawla Alasad, Zuelal Bas, Marteinn Snaebjörnsson, Ran Marciano, Katerina Scharov, Mélanie Planque, Kim Vriens, Stefan Christen, Cornelius M. Funk, Christina Hassiepen, Alisa Kahler, Beate Heider, Daniel Picard, Jonathan K. M. Lim, Anja Stefanski, Katja Bendrin, Andres Vargas-Toscano, Ulf D. Kahlert, Kai Stühler, Marc Remke, Moshe Elkabets, Thomas G. P. Grünewald, Andreas S. Reichert, Sarah-Maria Fendt, Almut Schulze, Guido Reifenberger, Barak Rotblat, Gabriel Leprivier
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Energetic stress compels cells to evolve adaptive mechanisms to adjust their metabolism. Inhibition of mTOR kinase complex 1 (mTORC1) is essential for cell survival during glucose starvation. How mTORC1 controls cell viability during glucose
Externí odkaz:
https://doaj.org/article/b77120ef8e324fda80f5122560600dc1
Autor:
Changwen Wang, Meng Sun, Chunxuan Shao, Lisa Schlicker, Yue Zhuo, Yassin Harim, Tianping Peng, Weili Tian, Nadja Stöffler, Martin Schneider, Dominic Helm, Youjun Chu, Beibei Fu, Xiaoliang Jin, Jan-Philipp Mallm, Moritz Mall, Yonghe Wu, Almut Schulze, Hai-Kun Liu
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-21 (2024)
Abstract Recent advances in the genomics of glioblastoma (GBM) led to the introduction of molecular neuropathology but failed to translate into treatment improvement. This is largely attributed to the genetic and phenotypic heterogeneity of GBM, whic
Externí odkaz:
https://doaj.org/article/d63afc60087d40eba8fc806d9ff1af6b
Autor:
Carsten Berndt, Hamed Alborzinia, Vera Skafar Amen, Scott Ayton, Uladzimir Barayeu, Alexander Bartelt, Hülya Bayir, Christina M. Bebber, Kivanc Birsoy, Jan P. Böttcher, Simone Brabletz, Thomas Brabletz, Ashley R. Brown, Bernhard Brüne, Giorgia Bulli, Alix Bruneau, Quan Chen, Gina M. DeNicola, Tobias P. Dick, Ayelén Distéfano, Scott J. Dixon, Jan B. Engler, Julia Esser-von Bieren, Maria Fedorova, José Pedro Friedmann Angeli, Manuel A. Friese, Dominic C. Fuhrmann, Ana J. García-Sáez, Karolina Garbowicz, Magdalena Götz, Wei Gu, Linda Hammerich, Behrouz Hassannia, Xuejun Jiang, Aicha Jeridi, Yun Pyo Kang, Valerian E. Kagan, David B. Konrad, Stefan Kotschi, Peng Lei, Marlène Le Tertre, Sima Lev, Deguang Liang, Andreas Linkermann, Carolin Lohr, Svenja Lorenz, Tom Luedde, Axel Methner, Bernhard Michalke, Anna V. Milton, Junxia Min, Eikan Mishima, Sebastian Müller, Hozumi Motohashi, Martina U. Muckenthaler, Shohei Murakami, James A. Olzmann, Gabriela Pagnussat, Zijan Pan, Thales Papagiannakopoulos, Lohans Pedrera Puentes, Derek A. Pratt, Bettina Proneth, Lukas Ramsauer, Raphael Rodriguez, Yoshiro Saito, Felix Schmidt, Carina Schmitt, Almut Schulze, Annemarie Schwab, Anna Schwantes, Mariluz Soula, Benedikt Spitzlberger, Brent R. Stockwell, Leonie Thewes, Oliver Thorn-Seshold, Shinya Toyokuni, Wulf Tonnus, Andreas Trumpp, Peter Vandenabeele, Tom Vanden Berghe, Vivek Venkataramani, Felix C.E. Vogel, Silvia von Karstedt, Fudi Wang, Frank Westermann, Chantal Wientjens, Christoph Wilhelm, Michele Wölk, Katherine Wu, Xin Yang, Fan Yu, Yilong Zou, Marcus Conrad
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103211- (2024)
Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various degenerative diseases and malignancies. The hallmark of ferroptosis is uncontrolled and overwhelming peroxidation of polyunsaturated fatty acids contained in membr
Externí odkaz:
https://doaj.org/article/704bf377a6004407992c3cd92011cf30
Autor:
Catherine Delbrouck, Nicole Kiweler, Oleg Chen, Vitaly I. Pozdeev, Lara Haase, Laura Neises, Anaïs Oudin, Aymeric Fouquier d’Hérouël, Ruolin Shen, Lisa Schlicker, Rashi Halder, Antoine Lesur, Anne Schuster, Nadja I. Lorenz, Christian Jaeger, Maureen Feucherolles, Gilles Frache, Martyna Szpakowska, Andy Chevigne, Michael W. Ronellenfitsch, Etienne Moussay, Marie Piraud, Alexander Skupin, Almut Schulze, Simone P. Niclou, Elisabeth Letellier, Johannes Meiser
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113034- (2023)
Summary: Metabolic rewiring is essential for cancer onset and progression. We previously showed that one-carbon metabolism-dependent formate production often exceeds the anabolic demand of cancer cells, resulting in formate overflow. Furthermore, we
Externí odkaz:
https://doaj.org/article/d667e6854d774c98bcdedc3d5a151980
Autor:
Hamed Alborzinia, Zhiyi Chen, Umut Yildiz, Florencio Porto Freitas, Felix C E Vogel, Julianna Patricia Varga, Jasmin Batani, Christoph Bartenhagen, Werner Schmitz, Gabriele Büchel, Bernhard Michalke, Jashuo Zheng, Svenja Meierjohann, Enrico Girardi, Elisa Espinet, Andrés F Flórez, Ancely Ferreira dosSantos, Nesrine Aroua, Tasneem Cheytan, Julie Haenlin, Lisa Schlicker, Thamara N Xavier da Silva, Adriana Przybylla, Petra Zeisberger, Giulio Superti‐Furga, Martin Eilers, Marcus Conrad, Marietta Fabiano, Ulrich Schweizer, Matthias Fischer, Almut Schulze, Andreas Trumpp, José Pedro Friedmann Angeli
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 8, Pp n/a-n/a (2023)
Abstract Ferroptosis has emerged as an attractive strategy in cancer therapy. Understanding the operational networks regulating ferroptosis may unravel vulnerabilities that could be harnessed for therapeutic benefit. Using CRISPR‐activation screens
Externí odkaz:
https://doaj.org/article/f738f088a5b24d4d84df76ffa09916f9
Autor:
Nadine Vollmuth, Lisa Schlicker, Yongxia Guo, Pargev Hovhannisyan, Sudha Janaki-Raman, Naziia Kurmasheva, Werner Schmitz, Almut Schulze, Kathrin Stelzner, Karthika Rajeeve, Thomas Rudel
Publikováno v:
eLife, Vol 11 (2022)
Chlamydia trachomatis (Ctr) can persist over extended times within their host cell and thereby establish chronic infections. One of the major inducers of chlamydial persistence is interferon-gamma (IFN-γ) released by immune cells as a mechanism of i
Externí odkaz:
https://doaj.org/article/b5901aba18994e7e8ed2c8f6ada5ed36
Autor:
Jessica Denise Schwarz, Sören Lukassen, Pranjali Bhandare, Lorenz Eing, Marteinn Thor Snaebjörnsson, Yiliam Cruz García, Jan Philipp Kisker, Almut Schulze, Elmar Wolf
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Cellular growth is a fundamental process of life and must be precisely controlled in multicellular organisms. Growth is crucially controlled by the number of functional ribosomes available in cells. The production of new ribosomes depends critically
Externí odkaz:
https://doaj.org/article/89c05fdd745a45f78a80af68cbaedfcd
Autor:
Oliver Hartmann, Michaela Reissland, Carina R. Maier, Thomas Fischer, Cristian Prieto-Garcia, Apoorva Baluapuri, Jessica Schwarz, Werner Schmitz, Martin Garrido-Rodriguez, Nikolett Pahor, Clare C. Davies, Florian Bassermann, Amir Orian, Elmar Wolf, Almut Schulze, Marco A. Calzado, Mathias T. Rosenfeldt, Markus E. Diefenbacher
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Lung cancer is the most common cancer worldwide and the leading cause of cancer-related deaths in both men and women. Despite the development of novel therapeutic interventions, the 5-year survival rate for non-small cell lung cancer (NSCLC) patients
Externí odkaz:
https://doaj.org/article/25bb6c9a9e3b4539a37791d85b52657e
Autor:
María Victoria Ruiz-Pérez, Lourdes Sainero-Alcolado, Ganna Oliynyk, Isabell Matuschek, Nicola Balboni, S.J. Kumari A. Ubhayasekera, Marteinn Thor Snaebjornsson, Kamil Makowski, Kristina Aaltonen, Daniel Bexell, Dolors Serra, Roland Nilsson, Jonas Bergquist, Almut Schulze, Marie Arsenian-Henriksson
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102128- (2021)
Summary: Many metabolic pathways, including lipid metabolism, are rewired in tumors to support energy and biomass production and to allow adaptation to stressful environments. Neuroblastoma is the second deadliest solid tumor in children. Genetic abe
Externí odkaz:
https://doaj.org/article/fdcde282d39e41aa9c4af63f5a3e2e3b
Autor:
Karin Bartel, Helmut Pein, Bastian Popper, Sabine Schmitt, Sudha Janaki-Raman, Almut Schulze, Florian Lengauer, Andreas Koeberle, Oliver Werz, Hans Zischka, Rolf Müller, Angelika M. Vollmar, Karin von Schwarzenberg
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-16 (2019)
Abstract Background The understanding of lysosomes has been expanded in recent research way beyond their view as cellular trash can. Lysosomes are pivotal in regulating metabolism, endocytosis and autophagy and are implicated in cancer. Recently it w
Externí odkaz:
https://doaj.org/article/44f0d07f9d1342d094461524911b0514