Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Almudena Pino-Angeles"'
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 1, p e1004570 (2016)
Magainin 2 and PGLa are among the best-studied cationic antimicrobial peptides. They bind preferentially to negatively charged membranes and apparently cause their disruption by the formation of transmembrane pores, whose detailed structure is still
Externí odkaz:
https://doaj.org/article/941b73a956fc40f89b80206d7dfb757b
Publikováno v:
Ding, T, Karlov, D S, Pino-Angeles, A & Tikhonova, I G 2022, ' Intermolecular interactions in G protein-coupled receptor allosteric sites at the membrane interface from molecular dynamics simulations and quantum chemical calculations ', Journal of Chemical Information and Modeling, vol. 62, no. 19, pp. 4736–4747 . https://doi.org/10.1021/acs.jcim.2c00788
Allosteric modulators are called promising candidates in G protein-coupled receptor (GPCR) drug development by displaying subtype selectivity and more specific receptor modulation. Among the allosteric sites known to date, cavities at the receptor-li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2c0f57a696a968bc4e0988e2faa73f1
https://pure.qub.ac.uk/en/publications/d024882a-8c0f-4835-a9aa-bacfaed4cac3
https://pure.qub.ac.uk/en/publications/d024882a-8c0f-4835-a9aa-bacfaed4cac3
Autor:
Almudena Pino-Angeles, María Isabel Jiménez Morales, Rocío Rodríguez-López, Francisca Sánchez-Jiménez, José Luis Urdiales
Publikováno v:
Pharmacological Research. 114:90-102
Human histidine decarboxylase (HDC) and dopa decarboxilase (DDC) are highly homologous enzymes responsible for the synthesis of biogenic amines (BA) like histamine, and serotonin and dopamine, respectively. The enzymes share many structural and funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15de7653f23665653744f24259948e25
https://doi.org/10.1016/j.phrs.2016.08.032
https://doi.org/10.1016/j.phrs.2016.08.032
Publikováno v:
Biophys J
Pore formation by membrane-active peptides, naturally encountered in innate immunity and infection, could have important medical and technological applications. Recently, the well-studied lytic peptide melittin has formed the basis for the developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf7a16c169647526ca738a314e9406a
https://pubmed.ncbi.nlm.nih.gov/32183940
https://pubmed.ncbi.nlm.nih.gov/32183940
Autor:
Aurelio A. Moya-García, Almudena Pino-Angeles, Francisca Sánchez-Jiménez, Miguel Ángel Medina, José Luis Urdiales
Publikováno v:
Biomolecules, Vol 11, Iss 415, p 415 (2021)
Biomolecules
Biomolecules
Histamine is a highly pleiotropic biogenic amine involved in key physiological processes including neurotransmission, immune response, nutrition, and cell growth and differentiation. Its effects, sometimes contradictory, are mediated by at least four
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0366c0e8b2efbe2e9fdd03d3e1fa7145
https://doi.org/10.3390/biom11030415
https://doi.org/10.3390/biom11030415
Publikováno v:
Biophysical Journal. 118:234a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c49d8ae6489bfe5314db992bebc21795
https://doi.org/10.1016/j.bpj.2019.11.1382
https://doi.org/10.1016/j.bpj.2019.11.1382
Publikováno v:
Biophysical journal. 114(12)
Melittin is a short cationic peptide that exerts cytolytic effects on bacterial and eukaryotic cells. Experiments suggest that in zwitterionic membranes, melittin forms transmembrane toroidal pores supported by four to eight peptides. A recently cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::707d096ce449634495c4ada9b7b0142c
https://pubmed.ncbi.nlm.nih.gov/29925023
https://pubmed.ncbi.nlm.nih.gov/29925023
Protegrin-1 is an 18-residue β-hairpin antimicrobial peptide (AMP) that has been suggested to form transmembrane β-barrels in biological membranes. However, alternative structures have also been proposed. Here, we performed multimicrosecond, all-at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8fd5d46775bae23baf92d70ef094e44
https://europepmc.org/articles/PMC5686775/
https://europepmc.org/articles/PMC5686775/
Autor:
Aurelio A. Moya-García, Francisca Sánchez-Jiménez, José Luis Urdiales, F. Sarabia, Lo Persson, A. R. Khomutov, R. Castro-Oropeza, Jouko Vepsäläinen, Almudena Pino-Angeles, M. A. Khomutov
Publikováno v:
Amino Acids. 46:621-631
Histamine plays highlighted roles in the development of many common, emergent and rare diseases. In mammals, histamine is formed by decarboxylation of L-histidine, which is catalyzed by pyridoxal-5'-phosphate (PLP) dependent histidine decarboxylase (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::608f4527f67115298b7e0a416c1e29a2
https://doi.org/10.1007/s00726-013-1589-7
https://doi.org/10.1007/s00726-013-1589-7
Autor:
Ana R. Quesada, Almudena Pino-Angeles, Miguel Ángel Medina, Javier A. García-Vilas, Beatriz Martínez-Poveda
Publikováno v:
RIUMA. Repositorio Institucional de la Universidad de Málaga
instname
instname
Este es el manuscrito que fue aceptado y que finalmente se publicó en Cancer Letters con el DOI: 10.1016/j.canlet.2016.10.037 The natural bioactive compound damnacanthal inhibits several tyrosine kinases. Herein, we show that -in fact- damancanthal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aec27d2b57b09743655d6f4109bd3fd
https://pubmed.ncbi.nlm.nih.gov/27816491
https://pubmed.ncbi.nlm.nih.gov/27816491