An adaptive phase II/III safety and efficacy randomized controlled trial of single day or three-day fixed-dose albendazole-ivermectin co-formulation versus albendazole for the treatment of Trichuris trichiura and other STH infections. ALIVE trial protocol [version 1; peer review: 2 approved]

Autor: Inacio Mandomando, Alejandro Krolewiecki, Javier Gandasegui, Wendemagegn Enbiale, Stella Kepha, Lisette van Lieshout, Michel Bengtson, Augusto Messa Junior, Valdemiro Escola, Woyneshet Gelaye, María Cambra-Pellejà, María Martinez-Valladares, Pedro Fleitas, Jaime Algorta, Stephen R. Doyle, Maria Rosa Ballester, Almudena Legarda, Nana Aba Williams, José Muñoz, Helena Martí-Soler, Charles Mwandawiro

Publikováno v: Gates Open Research, Vol 6 (2022)

Background: Soil-transmitted helminths (STH) are targeted for control through mass drug-administration campaigns to prevent morbidity affecting at-risk groups in endemic regions. Although broadly successful, the use of albendazole and mebendazole ach

Externí odkaz: https://doaj.org/article/26cd25d378dd4987a8a2caa032a316d2

Controlled human malaria infection by intramuscular and direct venous inoculation of cryopreserved Plasmodium falciparum sporozoites in malaria-naïve volunteers : effect of injection volume and dose on infectivity rates

Autor: Cecilia Justino Zita, Eric R. James, Gemma Moncunill, Benjamin Mordmüller, Pedro L. Alonso, Stephen L. Hoffman, Peter F. Billingsley, Peter G. Kremsner, Pau Cisteró, Gloria P Gómez-Pérez, Jose Muñoz, Carlota Dobaño, Anusha Gunasekera, Carlos Arlindo Nhamuave, Diana Barrios, Josefina Pardos, John J. Aponte, Joseph J. Campo, Alfons Jiménez, Caterina Guinovart, Marta Aldea, Rosa M. Antonijoan, Mireia Navarro, Maria Ballester, Anita Manoj, Almudena Legarda, B. Kim Lee Sim, Alberto L. García-Basteiro, Ariadna Sanz

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Malaria Journal
MALARIA JOURNAL
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Dipòsit Digital de la UB
Universidad de Barcelona
Malaria journal, 14(1). BioMed Central

BACKGROUND: Controlled human malaria infection (CHMI) by mosquito bite is a powerful tool for evaluation of vaccines and drugs against Plasmodium falciparum malaria. However, only a small number of research centres have the facilities required to per

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4aaa656ddb6ab68f969e8005db9faa
https://ddd.uab.cat/record/254415