Topographic mapping of the glioblastoma proteome reveals a triple-axis model of intra-tumoral heterogeneity

Autor: K. H. Brian Lam, Alberto J. Leon, Weili Hui, Sandy Che-Eun Lee, Ihor Batruch, Kevin Faust, Almos Klekner, Gábor Hutóczki, Marianne Koritzinsky, Maxime Richer, Ugljesa Djuric, Phedias Diamandis

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

Gioblastoma tumours consist of different niches defined by histology. Here, the authors use proteomics and machine learning to assign protein expression programs to these niches, and reveal that KRAS and hypoxia are associated with drug resistance.

Externí odkaz: https://doaj.org/article/247ebc3f13744c4b98c1b4e41d550bef

Data from Genetic Aberrations Leading to MAPK Pathway Activation Mediate Oncogene-Induced Senescence in Sporadic Pilocytic Astrocytomas

Autor: Nada Jabado, Uri Tabori, Stefan M. Pfister, V. Peter Collins, Andrey Korshunov, Cynthia Hawkins, Jeffrey Atkinson, Jose-Luis Montes, Jean-Pierre Farmer, Laszlo Bognar, Almos Klekner, Peter Hauser, Miklos Garami, Damien Faury, Margret Shirinian, Catherine Vezina, Olaf Witt, Steffen Albrecht, Sally Lambert, Hendrik Witt, David T.W. Jones, Dongh-Anh Quang-Khuong, Karine Jacob

Purpose: Oncogenic BRAF/Ras or NF1 loss can potentially trigger oncogene-induced senescence (OIS) through activation of the mitogen-activated protein kinase (MAPK) pathway. Somatic genetic abnormalities affecting this pathway occur in the majority of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5567367ea9831f8c13c50f6f3736ab7c
https://doi.org/10.1158/1078-0432.c.6518936

Prognosis and Treatment Outcomes of Patients Undergoing Resection of Brain Metastases from Breast Cancer

Autor: Edit Béres, Judit Tóth, Dezső Tóth, Almos Klekner, László Szivos, Péter Árkosy, János Nagy, József Virga

Publikováno v: Anticancer Research. 40:1759-1770

Background Brain metastases from breast cancer have poor prognosis and are a challenge to treat. Multiple treatment options are available. Descriptive and prognostic data on breast cancer brain metastases is limited. Patients and methods This study a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d249d7a04595d8dd2688c75401a6f898
https://doi.org/10.21873/anticanres.14130

Topographic mapping of the glioblastoma proteome reveals a triple-axis model of intra-tumoral heterogeneity

Autor: K. H. Brian Lam, Alberto J. Leon, Weili Hui, Sandy Che-Eun Lee, Ihor Batruch, Kevin Faust, Almos Klekner, Gábor Hutóczki, Marianne Koritzinsky, Maxime Richer, Ugljesa Djuric, Phedias Diamandis

Publikováno v: Nature Communications
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

Glioblastoma is an aggressive form of brain cancer with well-established patterns of intra-tumoral heterogeneity implicated in treatment resistance and progression. While regional and single cell transcriptomic variations of glioblastoma have been re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32acfe73ccf62968a0b0965527a456e6
https://pubmed.ncbi.nlm.nih.gov/35013227

The transcriptional landscape of Shh medulloblastoma

Autor: Jaume Mora, Erwin G. Van Meir, Olivier Delattre, Diala Abd-Rabbo, Almos Klekner, Peter Hauser, Roger E. McLendon, Amulya A. Nageswara Rao, David Malkin, James M. Olson, Boleslaw Lach, A. Sorana Morrissy, Xiaoyun Zhang, John J.Y. Lee, Steven J.M. Jones, Young Shin Ra, Ulrich Schüller, Miklós Garami, Joanna J. Phillips, Betty Luu, Hamza Farooq, Johan M. Kros, Karel Zitterbart, Michael K. Cooper, Raul Suarez, William A. Weiss, Quang M. Trinh, Ana Guerreiro Stucklin, Tomoko Shofuda, Carmen de Torres, Marco A. Marra, Enrique López-Aguilar, Hiromichi Suzuki, Patryk Skowron, Eric Bouffet, Karen Mungall, Evan Y. Wang, Tina Zheng, Maria C. Vladoiu, Julien Masliah-Planchon, Ian F. Pollack, Wai Sang Poon, Liam D. Hendrikse, Claudia C. Faria, Yu Chang Wang, Kay Ka Wai Li, Carlos Gilberto Carlotti, Joshua B. Rubin, Gary D. Bader, Aaron Gillmor, Caterina Giannini, Uri Tabori, Shin Jung, Franck Bourdeaut, Chi-chung Hui, Avesta Rastan, Reid C. Thompson, Jennifer A. Chan, Nada Jabado, David Meyronet, Rajeev Vibhakar, Jiannis Ragoussis, Michelle Ly, Olivier Ayrault, Charles G. Eberhart, Andrew J. Mungall, Wiesława Grajkowska, Xiaochong Wu, Jüri Reimand, Ho Keung Ng, Vernon Fong, Michael D. Taylor, Seung-Ki Kim, Florence M.G. Cavalli, Carolina Nor, Helen He Zhu, Eric M. Thompson, Borja L. Holgado, David Zagzag, Craig Daniels, Gelareh Zadeh, Haig Djambazian, G. Yancey Gillespie, Peter B. Dirks, Richard A. Moore, John A. Calarco, Shizhong Dai, Vijay Ramaswamy, Lincoln Stein, Pierre Bérubé, Pim J. French, Toshihiro Kumabe, James Loukides, Swneke D. Bailey, Linda M. Liau, Ronald L. Hamilton, Francois P. Doz, Maria Luisa Garrè, László Bognár

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12, pp.1749. ⟨10.1038/s41467-021-21883-0⟩
Nature communications, vol 12, iss 1
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nature Communications, 12(1):1749. Nature Publishing Group
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
NATURE COMMUNICATIONS
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu

Sonic hedgehog medulloblastoma encompasses a clinically and molecularly diverse group of cancers of the developing central nervous system. Here, we use unbiased sequencing of the transcriptome across a large cohort of 250 tumors to reveal differences

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2137115d6e36188a53e6a0ba7dbaf248
https://hal.archives-ouvertes.fr/hal-03405528/file/Skowron_Nat_com_2021.pdf