Integrating Genetic Alterations and Histopathological Features for Enhanced Risk Stratification in Non-Muscle-Invasive Bladder Cancer

Autor: Melinda Lillesand, Vebjørn Kvikstad, Einar Gudlaugsson, Ivar Skaland, Aida Slewa Johannessen, Almaz Nigatu Tesfahun, Sigmund Vegard Sperstad, Emiel A. M. Janssen, Marie Austdal

Publikováno v: Diagnostics, Vol 14, Iss 19, p 2137 (2024)

Background: Urothelial carcinoma presents as non-muscle-invasive bladder cancer (NMIBC) in ~75% of primary cases. Addressing the limitations of the TNM and WHO04/16 classification systems, this study investigates genetic alterations, the mitotic acti

Externí odkaz: https://doaj.org/article/3447ba89c1054086b413356606b62cba

The Escherichia coli alkA Gene Is Activated to Alleviate Mutagenesis by an Oxidized Deoxynucleoside

Autor: Kristin Grøsvik, Almaz Nigatu Tesfahun, Izaskun Muruzábal-Lecumberri, Gyri Teien Haugland, Ingar Leiros, Peter Ruoff, Jan Terje Kvaløy, Ingeborg Knævelsrud, Hilde Ånensen, Marina Alexeeva, Kousuke Sato, Akira Matsuda, Ingrun Alseth, Arne Klungland, Svein Bjelland

Publikováno v: Frontiers in Microbiology, Vol 11 (2020)

The cellular methyl donor S-adenosylmethionine (SAM) and other endo/exogenous agents methylate DNA bases non-enzymatically into products interfering with replication and transcription. An important product is 3-methyladenine (m3A), which in Escherich

Externí odkaz: https://doaj.org/article/280bd5dc7186445797b3732e6d822e02

Alleviation of C⋅C Mismatches in DNA by the

Autor: Almaz Nigatu, Tesfahun, Marina, Alexeeva, Miglė, Tomkuvienė, Aysha, Arshad, Prashanna, Guragain, Arne, Klungland, Saulius, Klimašauskas, Peter, Ruoff, Svein, Bjelland

Publikováno v: Frontiers in Microbiology

DNA polymerase III mis-insertion may, where not corrected by its 3′→ 5′ exonuclease or the mismatch repair (MMR) function, result in all possible non-cognate base pairs in DNA generating base substitutions. The most thermodynamically unstable b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7714eb1155c9071220e50be8427a58ad
https://pubmed.ncbi.nlm.nih.gov/34276575

Excision of uracil from DNA by hSMUG1 includes strand incision and processing

Autor: Marina Alexeeva, Peter Ruoff, Izaskun Muruzábal-Lecumberri, Kristin Grøsvik, Xiang Ming Xu, Almaz Nigatu Tesfahun, Arne Klungland, Anette Rasmussen, Marivi N. Moen, Finn Kirpekar, Kristine M. Olsen, Svein Bjelland

Publikováno v: Alexeeva, M, Moen, M N, Grøsvik, K, Tesfahun, A N, Xu, X M, Muruzábal-Lecumberri, I, Olsen, K M, Rasmussen, A, Ruoff, P, Kirpekar, F, Klungland, A & Bjelland, S 2019, ' Excision of uracil from DNA by hSMUG1 includes strand incision and processing ', Nucleic Acids Research, vol. 47, no. 2, pp. 779-793 . https://doi.org/10.1093/nar/gky1184
Nucleic Acids Research

Uracil arises in DNA by hydrolytic deamination of cytosine (C) and by erroneous incorporation of deoxyuridine monophosphate opposite adenine, where the former event is devastating by generation of C → thymine transitions. The base excision repair (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75365a8bc8f013d98f4a9e88573fb64b
http://hdl.handle.net/10852/71387

DHA-induced stress response in human colon cancer cells - Focus on oxidative stress and autophagy

Autor: Vivi Anita Talstad Monsen, Hilde Bremseth Overland, Geir Bjørkøy, Grete Klippenvåg Pettersen, Svanhild A. Schønberg, Anne Gøril Lundemo, Caroline Hild Pettersen, Helle Samdal, Kristine Pettersen, Almaz Nigatu Tesfahun

Publikováno v: Free Radical Biology & Medicine

Polyunsaturated fatty acids (PUFAs) are important constituents of the diet and health benefits of omega-3/n−3 PUFAs, especially eicosapentaenoic acid (EPA, 20:5 n−3) and docosahexaenoic acid (DHA, 22:6 n−3) have been well documented in relation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53fe2ec9abb532d729b620ed26db30a6
https://hdl.handle.net/11250/2456442