Hot-melt co-extrusion technology as a manufacturing platform for anti-hypertensive fixed-dose combinations

Autor: Ammar Almajaan, Anne-Marie Healy, David Jones, Gareth Colm Gilvary, Gavin Paul Andrews, Jeremiah Francis Kelleher, Shu Li, Yiwei Tian, Zoe Senta-Loys

Publikováno v: British Journal of Pharmacy, Vol 4, Iss 1 (2019)

This work focused on the development of a concentric multi-layered fixed-dose combination via an advanced manufacturing technique, hot-melt co-extrusion. The dosage form was designed to offer differing release behaviour; immediate and sustained relea

Externí odkaz: https://doaj.org/article/a84fd7c9f8de421aaf297b06189d0e88

Metformin Hydrochloride and Sitagliptin Phosphate Fixed Dose Combination Product Prepared Using Melt Granulation Continuous Processing Technology

Autor: Gareth C. Gilvary, Gavin Andrews, Shu Li, Zoe Senta Loys, Atif Madi, Jeremiah Kelleher, David S. Jones, Anne Marie Healy, Yiwei Tian, Ammar Almajaan

Publikováno v: Kelleher, J, Madi, A M, Gilvary, G C, Tian, Y W, Li, S, Almajaan, A, Senta Loys, Z, Jones, D, Andrews, G & Healy, A M 2019, ' Metformin Hydrochloride and Sitagliptin Phosphate Fixed Dose Combination Product Prepared Using Melt Granulation Continuous Processing Technology ', AAPS PharmSciTech, vol. 21 . https://doi.org/10.1208/s12249-019-1553-2

The development of oral solid dosage forms, such as tablets that contain a high dose of drug(s), requires polymers and other additives to be incorporated at low levels as possible, to keep the final tablet weight low, and, correspondingly, the dosage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b259d6eff78f1ec9df342f7d4390dcc9
https://pure.qub.ac.uk/en/publications/d6cf7089-5a67-4181-9253-a9903b1fd8ca

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Fixed Dose Combination Formulations: Multi-Layered Platforms Designed for the Management of Cardiovascular Disease

Autor: Gavin Andrews, David S. Jones, Shu Li, Tao Yu, Anne Marie Healy, Ammar Almajaan, Luigi Martini

Publikováno v: Andrews, G P, Li, S, Almajaan, A, Yu, T, Martini, L, Healy, A M & Jones, D S 2019, ' Fixed Dose Combination Formulations: Multi-Layered Platforms Designed for the Management of Cardiovascular Disease ', Molecular Pharmaceutics, vol. 16, no. 5, pp. 1827-1838 . https://doi.org/10.1021/acs.molpharmaceut.8b01068

Hyperlipidaemia is considered as one of the main risk factors associated with cardiovascular diseases (CVDs). Among different lipid-lowering agents used to manage hyperlipidaemia, statins are highly prescribed for management of hyperlipidaemia with s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1db147a0f2c40810e36b90337ddca55
https://pure.qub.ac.uk/en/publications/fixed-dose-combination-formulations-multilayered-platforms-designed-for-the-management-of-cardiovascular-disease(db0408c4-25d4-44b5-a24c-a92859dc5a44).html

The development of an inline Raman spectroscopic analysis method as a quality control tool for hot melt extruded ramipril fixed-dose combination products

Autor: Anne Marie Healy, Jeremiah Kelleher, Zoe Senta-Loys, Ammar Almajaan, David S. Jones, Gareth C. Gilvary, Atif Madi, Shu Li, Olivier P. Chevallier, Yiwei Tian, C. Elliot, Gavin Andrews

Publikováno v: Andrews, G P, Jones, D S, Senta-Loys, Z, Almajaan, A, Li, S, Chevallier, O, Elliott, C, Healy, A-M, Kelleher, J, Madi, A, Gilvary, G C & Tian, Y 2019, ' The development of an inline Raman spectroscopic analysis method as a quality control tool for hot melt extruded ramipril fixed-dose combination products ', International Journal of Pharmaceutics, vol. 566, pp. 476-487 . https://doi.org/10.1016/j.ijpharm.2019.05.029

Currently in the pharmaceutical industry, continuous manufacturing is an area of significant interest. In particular, hot-melt extrusion (HME) offers many advantages and has been shown to significantly reduce the number of processing steps relative t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e95d6ddd8aac5d71cd287d595f93536
https://pubmed.ncbi.nlm.nih.gov/31085253