Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Alma Fujisawa"'
Autor:
Tomonori Tamura, Tsuyoshi Ueda, Taiki Goto, Taku Tsukidate, Yonatan Shapira, Yuki Nishikawa, Alma Fujisawa, Itaru Hamachi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Chemically modifying proteins is hard to achieve selectively without purifying the target protein. Here, the authors present a method to modify proteins on lysine residues in living cells quicker than via known approaches and show that it can be used
Externí odkaz:
https://doaj.org/article/7cb4a42cb77f46bb9985a6f970724a6a
Autor:
Kohjiro Nagao, Itaru Hamachi, Yasushi Tamura, Yuying Shen, Toshiya Endo, Masaki Tsuchiya, Shin Kawano, Alma Fujisawa, Masato Umeda, Tomonori Tamura
Publikováno v:
Nature Chemical Biology. 16:1361-1367
Lipids play crucial roles as structural elements, signaling molecules and material transporters in cells. However, the functions and dynamics of lipids within cells remain unclear because of a lack of methods to selectively label lipids in specific o
Autor:
Yuki Nishikawa, Tomonori Tamura, Itaru Hamachi, Mikiko Takato, Hao Zhu, Rong Cheng, Alma Fujisawa
Publikováno v:
Journal of the American Chemical Society. 142(37)
Reactive oxygen species (ROS) such as hydrogen peroxide (H2O2) can inflict damage to biomolecules under oxidative stress and also act as signaling molecules at physiological levels. Here we developed a unique chemical tool to elucidate the biological
Autor:
Yonatan Shapira, Yuki Nishikawa, Tsuyoshi Ueda, Alma Fujisawa, Taiki Goto, Taku Tsukidate, Tomonori Tamura, Itaru Hamachi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Nature Communications
Selective modification of native proteins in live cells is one of the central challenges in recent chemical biology. As a unique bioorthogonal approach, ligand-directed chemistry recently emerged, but the slow kinetics limits its scope. Here we succe
Autor:
Hiromi Hayashi, Sam-Yong Park, Hiromi Doi, Tomoko Shoji, Hiroki Noguchi, Alma Fujisawa, Arnout Voet, Koji Tamura, Rina Hanabusa, Tadashi Ando, Risako Toki, Hideaki Miyake, Hiromi Mutsuro-Aoki, Takuya Umehara
Publikováno v:
Biochemical and biophysical research communications. 511(2)
This study reports the X-ray crystallographic structure of the glycyl-tRNA synthetase (GlyRS) of Nanoarchaeum equitans — a hyperthermophilic archaeal species. This is the first archaeal GlyRS crystal structure elucidated. The GlyRS comprises an N-t
Publikováno v:
Journal of the American Chemical Society. 140(49)
The endoplasmic reticulum (ER) is an organelle that performs a variety of essential cellular functions via interactions with other organelles. Despite its important role, chemical tools for profiling the composition and dynamics of ER proteins remain
Autor:
Shigeki Kiyonaka, Yuki Yasueda, Tomonori Tamura, Itaru Hamachi, Alma Fujisawa, Keiko Kuwata, Shinya Tsukiji
Publikováno v:
Journal of the American Chemical Society. 138(24)
Protein functions are tightly regulated by their subcellular localization in live cells, and quantitative evaluation of dynamically altered proteomes in each organelle should provide valuable information. Here, we describe a novel method for organell
Autor:
Yuki Yasueda, Tomonori Tamura, Alma Fujisawa, Keiko Kuwata, Shinya Tsukiji, Shigeki Kiyonaka, Itaru Hamachi
Publikováno v:
Journal of the American Chemical Society; 6/22/2016, Vol. 138 Issue 24, p7592-7602, 11p