Klebsiella oxytoca inhibits Salmonella infection through multiple microbiota-context-dependent mechanisms.

Autor: Osbelt L; Department of Microbial Immune Regulation, Helmholtz Center for Infection Research, Braunschweig, Germany.; ESF International Graduate School on Analysis, Imaging and Modelling of Neuronal and Inflammatory Processes, Otto-von-Guericke University, Magdeburg, Germany.; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany., Almási ÉDH; Department of Microbial Immune Regulation, Helmholtz Center for Infection Research, Braunschweig, Germany., Wende M; Department of Microbial Immune Regulation, Helmholtz Center for Infection Research, Braunschweig, Germany.; ESF International Graduate School on Analysis, Imaging and Modelling of Neuronal and Inflammatory Processes, Otto-von-Guericke University, Magdeburg, Germany., Kienesberger S; Institute of Molecular Biosciences, University of Graz, BioTechMed-Graz, Graz, Austria., Voltz A; Department Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarbrücken, Germany.; Department of Pharmacy, Saarland University, Saarbrücken, Germany., Lesker TR; Department of Microbial Immune Regulation, Helmholtz Center for Infection Research, Braunschweig, Germany., Muthukumarasamy U; Department of Microbial Immune Regulation, Helmholtz Center for Infection Research, Braunschweig, Germany., Knischewski N; Department of Microbial Immune Regulation, Helmholtz Center for Infection Research, Braunschweig, Germany., Nordmann E; Department of Microbial Immune Regulation, Helmholtz Center for Infection Research, Braunschweig, Germany., Bielecka AA; Department of Microbial Immune Regulation, Helmholtz Center for Infection Research, Braunschweig, Germany., Giralt-Zúñiga M; Institute for Biology-Molecular Microbiology, Humboldt-Universität zu Berlin, Berlin, Germany., Kaganovitch E; Institute for Biology-Molecular Microbiology, Humboldt-Universität zu Berlin, Berlin, Germany., Kühne C; Institute for Biology-Molecular Microbiology, Humboldt-Universität zu Berlin, Berlin, Germany., Baier C; Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany., Pietsch M; Division of Enteropathogenic Bacteria and Legionella (FG11)/National Reference Centre for Salmonella and other Bacterial Enteric Pathogens, Robert Koch Institute, Wernigerode, Germany., Müsken M; Central Facility for Microscopy, Helmholtz Centre for Infection Research, Braunschweig, Germany., Greweling-Pils MC; Mouse-Pathology Platform, Helmholtz Centre for Infection Research, Braunschweig, Germany., Breinbauer R; BioTechMed-Graz, Institute of Organic Chemistry, Graz University of Technology, Graz, Austria., Flieger A; Division of Enteropathogenic Bacteria and Legionella (FG11)/National Reference Centre for Salmonella and other Bacterial Enteric Pathogens, Robert Koch Institute, Wernigerode, Germany., Schlüter D; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany.; Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany.; German Center for Infection Research (DZIF),Partner Site Hannover-Braunschweig, Braunschweig, Germany., Müller R; Department Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarbrücken, Germany.; Department of Pharmacy, Saarland University, Saarbrücken, Germany.; German Center for Infection Research (DZIF),Partner Site Hannover-Braunschweig, Braunschweig, Germany., Erhardt M; Institute for Biology-Molecular Microbiology, Humboldt-Universität zu Berlin, Berlin, Germany.; Max Planck Unit for the Science of Pathogens, Berlin, Germany., Zechner EL; Institute of Molecular Biosciences, University of Graz, BioTechMed-Graz, Graz, Austria., Strowig T; Department of Microbial Immune Regulation, Helmholtz Center for Infection Research, Braunschweig, Germany. till.strowig@helmholtz-hzi.de.; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany. till.strowig@helmholtz-hzi.de.; German Center for Infection Research (DZIF),Partner Site Hannover-Braunschweig, Braunschweig, Germany. till.strowig@helmholtz-hzi.de.; Center for Individualized Infection Medicine, Hannover, Germany. till.strowig@helmholtz-hzi.de.

Publikováno v: Nature microbiology [Nat Microbiol] 2024 Jul; Vol. 9 (7), pp. 1792-1811. Date of Electronic Publication: 2024 Jun 11.

Systematically attenuating DNA targeting enables CRISPR-driven editing in bacteria.

Autor: Collias D; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), 97080, Würzburg, Germany.; Department of Chemical and Biomolecular Engineering, North Carolina State University, 27695, Raleigh, NC, USA., Vialetto E; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), 97080, Würzburg, Germany., Yu J; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), 97080, Würzburg, Germany., Co K; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), 97080, Würzburg, Germany., Almási ÉDH; Helmholtz Centre for Infection Research (HZI), 38124, Braunschweig, Germany., Rüttiger AS; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), 97080, Würzburg, Germany., Achmedov T; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), 97080, Würzburg, Germany., Strowig T; Helmholtz Centre for Infection Research (HZI), 38124, Braunschweig, Germany.; German Center for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Braunschweig, Germany., Beisel CL; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), 97080, Würzburg, Germany. chase.beisel@helmholtz-hiri.de.; Department of Chemical and Biomolecular Engineering, North Carolina State University, 27695, Raleigh, NC, USA. chase.beisel@helmholtz-hiri.de.; Medical Faculty, University of Würzburg, 97080, Würzburg, Germany. chase.beisel@helmholtz-hiri.de.

Publikováno v: Nature communications [Nat Commun] 2023 Feb 08; Vol. 14 (1), pp. 680. Date of Electronic Publication: 2023 Feb 08.