Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Allyson L. Toro"'
Autor:
Shaunaci A. Stevens, Maria K. Gonzalez Aguiar, Allyson L. Toro, Esma I. Yerlikaya, Siddharth Sunilkumar, Ashley M. VanCleave, Jessica Pfleger, Elisa A. Bradley, Scot R. Kimball, Michael D. Dennis
Publikováno v:
American journal of physiology. Endocrinology and metabolism.
Endoplasmic reticulum (ER) stress and inflammation are hallmarks of myocardial impairment. Here we investigated a role for the stress response protein REDD1 as a molecular link between ER stress and inflammation in cardiomyocytes. In mice fed a high-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac849f5a5cb6ad4931aad7adf30d178
https://pubmed.ncbi.nlm.nih.gov/36383638
https://pubmed.ncbi.nlm.nih.gov/36383638
Spleen Tyrosine Kinase Contributes to Müller Glial Expression of Proangiogenic Cytokines in Diabetes
Autor:
Esma I. Yerlikaya, Allyson L. Toro, Siddharth Sunilkumar, Ashley M. VanCleave, Ming Leung, Yuka Imamura Kawasawa, Scot R. Kimball, Michael D. Dennis
Publikováno v:
Investigative ophthalmologyvisual science. 63(11)
Neuroglial dysfunction occurs early in the progression of diabetic retinopathy. In response to diabetes or hypoxia, Müller glia secrete cytokines and growth factors that contribute to disease progression. This study was designed to examine common si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d46c87ea5b67b81f670c3dfc27ea151c
https://pubmed.ncbi.nlm.nih.gov/36306144
https://pubmed.ncbi.nlm.nih.gov/36306144
Autor:
Siddharth Sunilkumar, Esma I. Yerlikaya, Allyson L. Toro, William P. Miller, Han Chen, Kebin Hu, Scot R. Kimball, Michael D. Dennis
Chronic hyperglycemia contributes to development of diabetic kidney disease by promoting glomerular injury. In this study, we evaluated the hypothesis that hyperglycemic conditions promote expression of the stress response protein regulated in develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::372e88f967f148cb5d912070a21c5430
https://doi.org/10.2337/figshare.20503266
https://doi.org/10.2337/figshare.20503266
Publikováno v:
Circulation Research. 131
Obesity and type 2 diabetes represent a surging public health crisis, impacting nearly half of American adults. Heart failure is a leading cause of mortality and morbidity in patients with diabetes and obesity. Much remains unknown regarding the mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf25ecdd79cc1a25b032ff45757e800c
https://doi.org/10.1161/res.131.suppl_1.p1074
https://doi.org/10.1161/res.131.suppl_1.p1074
Autor:
Michael D. Dennis, Siddharth Sunilkumar, Shaunaci A. Stevens, Allyson L. Toro, Scot R. Kimball, Carson J. Purnell, Jaclyn E. Welles
Publikováno v:
Am J Physiol Endocrinol Metab
Increased expression of the peptide hormone retinol-binding protein 4 (RBP4) has been implicated in the development of insulin resistance, type 2 diabetes, and visual dysfunction. Prior investigations of the mechanisms that influence RBP4 synthesis h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3cb6871bcc52f8347fc1ddc8a4ed2fb
https://doi.org/10.1152/ajpendo.00494.2020
https://doi.org/10.1152/ajpendo.00494.2020
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93a06c81a8cdbd4e964bcbfcefe7b963
https://doi.org/10.1096/fasebj.2022.36.s1.r3610
https://doi.org/10.1096/fasebj.2022.36.s1.r3610
Autor:
William P. Miller, Congzhou M. Sha, Siddharth Sunilkumar, Allyson L. Toro, Ashley M. VanCleave, Scot R. Kimball, Nikolay V. Dokholyan, Michael D. Dennis
Publikováno v:
Diabetes. 71(12)
The stress response protein regulated in development and DNA damage response 1 (REDD1) has been implicated in visual deficits in diabetic patients. The aim here was to investigate the mechanism responsible for the increase in retinal REDD1 protein co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0acf284a89d720768eae7d9f9bc148aa
https://pubmed.ncbi.nlm.nih.gov/36170669
https://pubmed.ncbi.nlm.nih.gov/36170669
Autor:
Siddharth Sunilkumar, Sadie K. Dierschke, Allyson L. Toro, Michael D. Dennis, William P. Miller
Publikováno v:
Journal of Biological Chemistry. 295:10831-10841
Activation of the immune costimulatory molecule cluster of differentiation 40 (CD40) in Muller glia has been implicated in the initiation of diabetes-induced retinal inflammation. Results from previous studies support that CD40 protein expression is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0875538a1d81813f56589c935795a80a
https://doi.org/10.1074/jbc.ra120.013711
https://doi.org/10.1074/jbc.ra120.013711
Autor:
Allyson L. Toro, Michael D. Dennis, Joseph Giordano, Alistair J. Barber, William P. Miller, Siddharth Sunilkumar
Publikováno v:
J Biol Chem
The transcription factor nuclear factor erythroid-2-related factor 2 (Nrf2) plays a critical role in reducing oxidative stress by promoting the expression of antioxidant genes. Both individuals with diabetes and preclinical diabetes models exhibit ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926e9e9709c2373115c4bbfe3c183552
https://doi.org/10.1074/jbc.ra120.013093
https://doi.org/10.1074/jbc.ra120.013093
Autor:
William P. Miller, Allyson L. Toro, Siddharth Sunilkumar, Shaunaci A. Stevens, Ashley M. VanCleave, David L. Williamson, Alistair J. Barber, Michael D. Dennis
Publikováno v:
Diabetes. 71(5)
Clinical studies support a role for the protein regulated in development and DNA damage response 1 (REDD1) in ischemic retinal complications. To better understand how REDD1 contributes to retinal pathology, we examined human single-cell sequencing da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e9afa81441f91d77335a4f8027a05d
https://pubmed.ncbi.nlm.nih.gov/35167652
https://pubmed.ncbi.nlm.nih.gov/35167652