Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Allyson K Palmer"'
Autor:
Hui Tang, Lilach O Lerman, Xiaohui Bian, Tomás P Griffin, Xiangyang Zhu, Md Nahidul Islam, Sabena M Conley, Alfonso Eirin, Paula M O’Shea, Allyson K Palmer, Sandra M Herrmann, Ramila A Mehta, John R Woollard, Andrew D Rule, James L Kirkland, Tamar Tchkonia, Stephen C Textor, Matthew D Griffin, LaTonya J Hickson
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 7, Iss 1 (2019)
Objective Activin A, an inflammatory mediator implicated in cellular senescence-induced adipose tissue dysfunction and profibrotic kidney injury, may become a new target for the treatment of diabetic kidney disease (DKD) and chronic kidney diseases.
Externí odkaz:
https://doaj.org/article/60ce9afc505b4b7c971e0dda7eb4788a
Autor:
Ming Xu, Allyson K Palmer, Husheng Ding, Megan M Weivoda, Tamar Pirtskhalava, Thomas A White, Anna Sepe, Kurt O Johnson, Michael B Stout, Nino Giorgadze, Michael D Jensen, Nathan K LeBrasseur, Tamar Tchkonia, James L Kirkland
Publikováno v:
eLife, Vol 4 (2015)
Senescent cells accumulate in fat with aging. We previously found genetic clearance of senescent cells from progeroid INK-ATTAC mice prevents lipodystrophy. Here we show that primary human senescent fat progenitors secrete activin A and directly inhi
Externí odkaz:
https://doaj.org/article/ec852c46c83c4207854436df1e2e57e8
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101601- (2022)
Cellular senescence is a cell fate involving cell cycle arrest, resistance against apoptosis, and the development of a secretome that can be pro-inflammatory. In aging and obesity, senescent cells accumulate in many tissues, including adipose tissue,
Externí odkaz:
https://doaj.org/article/27d3f1b26b264caeadbc2f367227900f
Autor:
Allyson K. Palmer, Michael D. Jensen
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 16 (2022)
Aging and metabolism are inextricably linked, and many age-related changes in body composition, including increased central adiposity and sarcopenia, have underpinnings in fundamental aging processes. These age-related changes are further exacerbated
Externí odkaz:
https://doaj.org/article/2f572606a2134cd4ac997de48a291801
Publikováno v:
J Clin Endocrinol Metab
The elderly population is increasing faster than other segments of the population throughout the world. Age is the leading predictor for most chronic diseases and disorders, multimorbidity, geriatric syndromes, and impaired ability to recover from ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71185bb2a1d7c8260ff9c938012c3fcf
https://doi.org/10.1210/clinem/dgaa728
https://doi.org/10.1210/clinem/dgaa728
Autor:
Lichao Wang, Binsheng Wang, Nathan S. Gasek, Yueying Zhou, Rachel L. Cohn, Dominique E. Martin, Wulin Zuo, William F. Flynn, Chun Guo, Evan R. Jellison, Taewan Kim, Larissa G.P. Langhi Prata, Allyson K. Palmer, Ming Li, Christina L. Inman, Lauren S. Barber, Iman M.A. Al-Naggar, Yanjiao Zhou, Wenqiang Du, null Kshitiz, George A. Kuchel, Alexander Meves, Tamar Tchkonia, James L. Kirkland, Paul Robson, Ming Xu
Publikováno v:
Cell Metab
Insulin resistance is a pathological state often associated with obesity, representing a major risk factor for type 2 diabetes. Limited mechanism-based strategies exist to alleviate insulin resistance. Here, using single-cell transcriptomics, we iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1d77c97bb9b099109e3f03b8f5948f
https://europepmc.org/articles/PMC8832725/
https://europepmc.org/articles/PMC8832725/
Autor:
Shariq Abid, Serge Adnot, Alvar Agusti, Delphine Beaulieu, Anil Bhushan, Thomas G. Bird, Emmanuelle Born, Marielle Breau, Alexander F. Chin, Jennifer H. Elisseeff, Zulrahman Erlangga, Konstantinos Evangelou, Rosa Faner, Joshua N. Farr, Eleni Georgakopoulou, Estela González-Gualda, Vassilis G. Gorgoulis, Elise Gray-Gaillard, Jin Han, Fernanda Hernandez-Gonzalez, Amal Houssaini, Michael D. Jensen, Diana Jurk, Goro Katsuumi, Sundeep Khosla, Christos Kiourtis, James L. Kirkland, Marta Kovatcheva, Larissa Lipskaia, Jose Alberto López-Domínguez, David Macías, Elisabeth Marcos, Mate Maus, Anette Melk, Kathleen Meyer, John Michel, Tohru Minamino, Satomi Miwa, David G. Monroe, Daniel Muñoz-Espín, Hui-Ling Ou, Allyson K. Palmer, Nayuta Saito, Roland Schmitt, Jacobo Sellares, Manuel Serrano, Myong-Hee Sung, Tamara Tchkonia, Peter J. Thompson, Thomas von Zglinicki, Tengfei Wan, Peisu Zhang
Publikováno v:
Cellular Senescence in Disease ISBN: 9780128225141
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86b75ae32a421dd67dc1780eb3c723f4
https://doi.org/10.1016/b978-0-12-822514-1.01002-6
https://doi.org/10.1016/b978-0-12-822514-1.01002-6
Publikováno v:
Cellular Senescence in Disease ISBN: 9780128225141
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4ee2376700c5320f39be742fa0dc009
https://doi.org/10.1016/b978-0-12-822514-1.00009-2
https://doi.org/10.1016/b978-0-12-822514-1.00009-2
Publikováno v:
Diabetologia
Ageing and diabetes lead to similar organ dysfunction that is driven by parallel molecular mechanisms, one of which is cellular senescence. The abundance of senescent cells in various tissues increases with age, obesity and diabetes. Senescent cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eff45afcc2ea577fade2e28d3c2be0f
https://doi.org/10.1007/s00125-019-4934-x
https://doi.org/10.1007/s00125-019-4934-x
Autor:
Andrzej Bartke, Shadab A. Siddiqi, Augusto Schneider, Michael B. Stout, Yimin Fang, John J. Kopchick, Michal M. Masternak, Silvana Sidhom, Frederik J. Steyn, Justin Darcy, Samuel McFadden, Johannes Grillari, Allyson K. Palmer, Roshini Sathiaseelan
Publikováno v:
J Gerontol A Biol Sci Med Sci
Aging is the greatest risk factor for most chronic diseases. The somatotropic axis is one of the most conserved biological pathways that regulates aging across species. 17α-Estradiol (17α-E2), a diastereomer of 17β-estradiol (17β-E2), was recentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac796cf76bc16ee5febdaab6abd1d6f
https://pubmed.ncbi.nlm.nih.gov/32857104
https://pubmed.ncbi.nlm.nih.gov/32857104