Výsledky vyhledávání - "Allyson E. Vaughn"

Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c

Autor: Allyson E. Vaughn, Mohanish Deshmukh

Publikováno v: Nature cell biology

Summary Paragraph Neurons and cancer cells utilize glucose extensively, yet the precise advantage of this adaptation remains elusive. These two seemingly disparate cell types also exhibit an increased regulation of the apoptotic pathway, which allows

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78b632a35530a2887b18832f15fff08
https://doi.org/10.1038/ncb1807

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Differential Apaf-1 levels allow cytochrome c to induce apoptosis in brain tumors but not in normal neural tissues

Autor: Carrie E. Johnson, Qian Zhang, Michelle I. Smith, Sally Kornbluth, Terry Van Dyke, Amanda B. Parrish, Robert J. Wechsler-Reya, Allyson E. Vaughn, Kevin M. Wright, Yolanda Y. Huang, Mohanish Deshmukh

Publikováno v: Proceedings of the National Academy of Sciences. 104:20820-20825

Brain tumors are typically resistant to conventional chemotherapeutics, most of which initiate apoptosis upstream of mitochondrial cytochrome c release. In this study, we demonstrate that directly activating apoptosis downstream of the mitochondria,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e6a7a678bec9fb1e79c67101d5eb2a
https://doi.org/10.1073/pnas.0709101105

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Essential postmitochondrial function of p53 uncovered in DNA damage-induced apoptosis in neurons

Autor: Allyson E. Vaughn, Mohanish Deshmukh

Publikováno v: Cell Death & Differentiation. 14:973-981

In postmitotic sympathetic neurons, unlike most mitotic cells, death by apoptosis requires not only the release of cytochrome c from the mitochondria, but also an additional step to relieve X-linked inhibitor of apoptosis protein (XIAP)'s inhibition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8922de35a4f5630634da15026fe27fe
https://doi.org/10.1038/sj.cdd.4402084

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Apoptosome dependent caspase-3 activation pathway is non-redundant and necessary for apoptosis in sympathetic neurons

Autor: Kevin M. Wright, Mohanish Deshmukh, Allyson E. Vaughn

Publikováno v: Cell Death & Differentiation. 14:625-633

Although sympathetic neurons are a well-studied model for neuronal apoptosis, the role of the apoptosome in activating caspases in these neurons remains debated. We find that the ability of sympathetic neurons to undergo apoptosis in response to nerv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9752fef44e58dfc1248a47bca545558e
https://doi.org/10.1038/sj.cdd.4402024

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Reduced Apaf-1 levels in cardiomyocytes engage strict regulation of apoptosis by endogenous XIAP

Autor: Holly McDonough, Mohanish Deshmukh, Cam Patterson, Malia B. Potts, Allyson E. Vaughn

Publikováno v: The Journal of Cell Biology

Overexpression studies have identified X-linked inhibitor of apoptosis protein (XIAP) as a potent inhibitor of caspases. However, the exact function of endogenous XIAP in regulating mammalian apoptosis is less clear. Endogenous XIAP strictly regulate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0b55b4908db94fbcad68683a8096b8

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