Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Allyson D Roe"'
Autor:
Samantha B Nicholls, Sarah L DeVos, Caitlin Commins, Chloe Nobuhara, Rachel E Bennett, Diana L Corjuc, Eduardo Maury, Bahareh Eftekharzadeh, Ololade Akingbade, Zhanyun Fan, Allyson D Roe, Shuko Takeda, Susanne Wegmann, Bradley T Hyman
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177914 (2017)
The spread of neurofibrillary tangle (NFT) pathology through the human brain is a hallmark of Alzheimer's disease (AD), which is thought to be caused by the propagation of "seeding" competent soluble misfolded tau. "TauC3", a C-terminally truncated f
Externí odkaz:
https://doaj.org/article/6b7577e645ef4883bb7ef913fa08713d
Autor:
Maria Calvo-Rodriguez, Bradley T. Hyman, Allyson D. Roe, Susanne Wegmann, Jordan D. Marks, Eleanna Kara, Caitlin Commins, Eloise Hudry, Zhanyun Fan
Publikováno v:
Journal of Biological Chemistry. 293:13247-13256
Apolipoprotein E (ApoE) is a secreted apolipoprotein with three isoforms, E2, E3, and E4, that binds to lipids and facilitates their transport in the extracellular environment of the brain and the periphery. The E4 allele is a major genetic risk fact
Autor:
Hsin-Yi Wu, Chia-Li Han, Hwan-Ching Tai, Hao-Tai Lin, Yi-Ting Wang, Po-Cheng Kuo, Yu-Ju Chen, Bradley T. Hyman, Allyson D. Roe, Bo Y Wang
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 77:814-826
A synergy between β-amyloid (Aβ) and tau appears to occur in Alzheimer disease (AD), but the mechanisms of interaction, and potential locations, are little understood. This study investigates the possibility of such interactions within the cortical
Autor:
Tara L. Spires-Jones, Claudia Cannavo, Bradley T. Hyman, Taylie Sargent, Rebecca A. Betensky, Jacob Aaron Klickstein, Kishore V. Kuchibhotla, Eloise Hudry, Alona Muzikansky, Lauren Wrobleski, Allyson D. Roe, David Urick, Steven S. Hou, Rosemary J. Jackson, Sheetal Gandhi
Publikováno v:
Life Science Alliance
Hudry, E, Klickstein, J, Cannavo, C, Jackson, R, Muzikansky, A, Gandhi, S, Urick, D, Sargent, T, Wrobleski, L, Roe, A D, Hou, S S, Kuchibhotla, K V, Betensky, R A, Spires-Jones, T & Hyman, B T 2019, ' Opposing Roles of apolipoprotein E in aging and neurodegeneration ', Life Science Alliance, vol. 2, no. 1 . https://doi.org/10.26508/lsa.201900325
Hudry, E, Klickstein, J, Cannavo, C, Jackson, R, Muzikansky, A, Gandhi, S, Urick, D, Sargent, T, Wrobleski, L, Roe, A D, Hou, S S, Kuchibhotla, K V, Betensky, R A, Spires-Jones, T & Hyman, B T 2019, ' Opposing Roles of apolipoprotein E in aging and neurodegeneration ', Life Science Alliance, vol. 2, no. 1 . https://doi.org/10.26508/lsa.201900325
This study investigates how APOE modulates neuronal function integrity during normal aging and in the context of amyloidosis. This work demonstrates that APOE is a necessary partner of Aβ-dependent neuronal dysfunction and synaptotoxicity but also p
Autor:
Rose Pitstick, Mehdi Jorfi, Jose A Gonzales, Bradley T. Hyman, Daniel Irimia, Patrick M. Dooley, George A. Carlson, Matthew P. Frosch, Riley N. Bannon, Benjamin D. Moore, Sarah L. DeVos, Allyson D. Roe, Diana L. Corjuc, Caitlin Commins, Rachel E. Bennett, Bianca T. Corjuc, Simon Dujardin
Several studies have now supported the use of a tau lowering agent as a possible therapy in the treatment of tauopathy disorders, including Alzheimer's disease. In human Alzheimer's disease, however, concurrent amyloid-β deposition appears to synerg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb5796816ae863af71c6ae261d8fc484
https://europepmc.org/articles/PMC6022692/
https://europepmc.org/articles/PMC6022692/
Autor:
Sarah C. Hopp, Sarah L. DeVos, Yang Lin, Derek H. Oakley, Bradley T. Hyman, David Hanlon, Allyson D. Roe
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-15 (2018)
Background Misfolding of microtubule-associated protein tau (MAPT) within neurons into neurofibrillary tangles is an important pathological feature of Alzheimer’s disease (AD). Tau pathology correlates with cognitive decline in AD and follows a ste
Autor:
Zhanyun Fan, Tarun V. Kamath, Anthony A. Hyman, Charles R. Vanderburg, J. Paul Taylor, Bahareh Eftekharzadeh, Amandine Molliex, Bradley T. Hyman, Katarzyna Marta Zoltowska, Katharina Tepper, Rachel E. Bennett, Allyson D. Roe, Pawel R. Laskowski, Susanne Wegmann, Amayra Hernández-Vega, Daniel J. Müller, Caitlin Commins, Eckhard Mandelkow, Simon Dujardin, Danny MacKenzie
Publikováno v:
EMBO Journal
The EMBO Journal
The EMBO journal 37(7), e98049 (2018). doi:10.15252/embj.201798049
The EMBO Journal
The EMBO journal 37(7), e98049 (2018). doi:10.15252/embj.201798049
The transition between soluble intrinsically disordered tau protein and aggregated tau in neurofibrillary tangles in Alzheimer's disease is unknown. Here, we propose that soluble tau species can undergo liquid–liquid phase separation (LLPS) under c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9167a871aa08aef02aee28352f25acf4
https://hdl.handle.net/21.11116/0000-0003-53A6-421.11116/0000-0003-53A8-2
https://hdl.handle.net/21.11116/0000-0003-53A6-421.11116/0000-0003-53A8-2
Autor:
Eleanna, Kara, Jordan D, Marks, Allyson D, Roe, Caitlin, Commins, Zhanyun, Fan, Maria, Calvo-Rodriguez, Susanne, Wegmann, Eloise, Hudry, Bradley T, Hyman
Publikováno v:
The Journal of biological chemistry. 293(34)
Apolipoprotein E (ApoE) is a secreted apolipoprotein with three isoforms, E2, E3, and E4, that binds to lipids and facilitates their transport in the extracellular environment of the brain and the periphery. The E4 allele is a major genetic risk fact
Autor:
Nickey Lee, Louise Monte, Michael C. Donohue, Kathleen U. Lao, Allyson D. Roe, Shannon N. Campbell, Cheng Zhang, Robert A. Rissman
Publikováno v:
Journal of Alzheimer's Disease. 45:1175-1184
Stress exposure and the corticotropin-releasing factor (CRF) system have been implicated as mechanistically involved in both Alzheimer's disease (AD) and associated rodent models. In particular, the major stress receptor, CRF receptor type 1 (CRFR1),
Autor:
Shannon N. Campbell, Cheng Zhang, Eliezer Masliah, Louise Monte, Yvette Taché, Allyson D. Roe, Robert A. Rissman, Kenner C. Rice
Publikováno v:
Journal of Alzheimer's disease : JAD, vol 43, iss 3
Clinical and basic science research suggests that stress and/or changes in central stress signaling intermediates may be involved in Alzheimer's disease (AD) pathogenesis. Although the links between stress and AD remain unsettled, data from our group