Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Allysa L Cole"'
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80706 (2013)
Alzheimer's disease (AD), the most common cause of dementia in the elderly, has two pathological hallmarks: Aβ plaques and aggregation of hyperphosphorylated tau (p-tau). Aβ is a cleavage product of Amyloid Precursor Protein (APP). Presenilin 1 (PS
Externí odkaz:
https://doaj.org/article/fd48621a8fb244fe9fa698bc23f943a9
Autor:
Allysa L. Cole, Andelience Croce, Janice B. Harvey, Brittany Enders, Kayla Perry, Barry A. Hedgespeth, Tatiane Terumi Negrão Watanabe
Publikováno v:
Journal of the American Veterinary Medical Association. 259(S2)
In collaboration with the American College of Veterinary Pathologists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba90f6cefe9f23303bd9b0fa90efe672
https://pubmed.ncbi.nlm.nih.gov/35587905
https://pubmed.ncbi.nlm.nih.gov/35587905
Publikováno v:
J Vet Diagn Invest
Two aborted Chester White pig fetuses were presented to a veterinary diagnostic laboratory in Illinois. Postmortem examination identified no gross abnormalities. Histologic evaluation revealed multifocal necrosis of chorionic epithelial cells, coales
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51ebf5e9346c1f93b27b61d5b958116d
https://europepmc.org/articles/PMC8689021/
https://europepmc.org/articles/PMC8689021/
Autor:
Hui Zheng, Oleg Butovsky, Gabriel Chiu, Allysa L. Cole, Virginia M.-Y. Lee, Zhuoran Yin, Baiping Wang, Wei Cao, Ying-Wooi Wan, Stephen D. Ginsberg, Nicholas E. Propson, Joanna L. Jankowsky, Zhandong Liu, Yin Xu, John Q. Trojanowski, Ethan R. Roy
Publikováno v:
J Clin Invest
J Alzheimers Dis
J Alzheimers Dis
Type I interferon (IFN) is a key cytokine that curbs viral infection and cell malignancy. Previously, we demonstrated a potent IFN immunogenicity of nucleic acid–containing (NA-containing) amyloid fibrils in the periphery. Here, we investigated whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d554e3c890daaefea734e4cce10047
https://europepmc.org/articles/PMC7108898/
https://europepmc.org/articles/PMC7108898/
Autor:
Marco Sardiello, Ying-Wooi Wan, John Q. Trojanowski, Virginia M.-Y. Lee, Lakshya Bajaj, Allysa L. Cole, Dan B. Swartzlander, Fading Chen, Hui Zheng, David A. Bader, Zhandong Liu, Heidi Martini-Stoica
Publikováno v:
The Journal of Experimental Medicine
Martini-Stoica et al. demonstrate that the TFEB-mediated lysosomal pathway in astrocytes is increased in tauopathy and plays a functional role in modulating extracellular tau and the propagation of neuronal tau pathology in a mouse model of tau sprea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dcd9d81c0332c322d5f894f9a2841a5
http://europepmc.org/articles/PMC6122971
http://europepmc.org/articles/PMC6122971
Autor:
Longwen Huang, Albert J. Hunt, Hui Zheng, Michael X. Zhu, Jinbin Tian, Melissa Pruski, Rene Flores, Benjamin R. Arenkiel, Nicholas J. Justice, Allysa L. Cole
Publikováno v:
The Journal of Neuroscience. 35:2612-2623
Recent studies have found that those who suffer from posttraumatic stress disorder (PTSD) are more likely to experience dementia as they age, most often Alzheimer's disease (AD). These findings suggest that the symptoms of PTSD might have an exacerba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f72a2a65a38b553932edb36d804d378
https://doi.org/10.1523/jneurosci.3333-14.2015
https://doi.org/10.1523/jneurosci.3333-14.2015
Publikováno v:
Alzheimer's & Dementia. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d33e1533113e33f403a67d3f235178a
https://doi.org/10.1016/j.jalz.2017.07.115
https://doi.org/10.1016/j.jalz.2017.07.115
The Amyloid Precursor Protein Controls Adult Hippocampal Neurogenesis through GABAergic Interneurons
Autor:
Hui Zheng, Lu Sun, Zilai Wang, Jennifer Rodriguez-Rivera, Baiping Wang, Allysa L. Cole, Hongmei Li, Hui-Chen Lu, Li Yang
Publikováno v:
The Journal of Neuroscience. 34:13314-13325
Impaired neurogenesis in the adult hippocampus has been implicated in AD pathogenesis. Here we reveal that the APP plays an important role in the neural progenitor proliferation and newborn neuron maturation in the mouse dentate gyrus. APP controls a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a640b5f4ee3484243fe27bf3861400d8
https://doi.org/10.1523/jneurosci.2848-14.2014
https://doi.org/10.1523/jneurosci.2848-14.2014
Autor:
Alexandra Litvinchuk, Ying Wooi Wan, Qian Wang, Fading Chen, Allysa L. Cole, Zhandong Liu, Nicholas E. Propson, Hui Zheng, Dan B. Swartzlander, Bin Zhang
Publikováno v:
Neuron. 100:1337-1353.e5
Summary Strong evidence implicates the complement pathway as an important contributor to amyloid pathology in Alzheimer’s disease (AD); however, the role of complement in tau modulation remains unclear. Here we show that the expression of C3 and C3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4b590217377503371509a6932b2c69
https://doi.org/10.1016/j.neuron.2018.10.031
https://doi.org/10.1016/j.neuron.2018.10.031
Autor:
Giulio Taglialatela, David J Shim, Jennifer Rodriguez-Rivera, Allysa L. Cole, Hui Zheng, Joanna L. Jankowsky, Li Yang, Angie C.A. Chiang, Stephanie W. Fowler, Hong Lian, Hui-Chen Lu, Lu Sun
SummaryAbnormal NFκB activation has been implicated in Alzheimer’s disease (AD). However, the signaling pathways governing NFκB regulation and function in the brain are poorly understood. We identify complement protein C3 as an astroglial target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1219d411e8cad3159b8ffcecba5bbeb
https://europepmc.org/articles/PMC4289109/
https://europepmc.org/articles/PMC4289109/