Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Allyn Michael Kaufmann"'
Publikováno v:
Analytical Biochemistry. 386:91-97
Traditionally, lysosomes have been considered to be a terminal endocytic compartment. Recent studies suggest that lysosomes are quite dynamic, being able to fuse with other late endocytic compartments as well as with the plasma membrane. Here we desc
Publikováno v:
Journal of Biological Chemistry. 283:24584-24593
Mutations in the late endosomal/lysosomal membrane protein Niemann-Pick C1 (NPC1) are known to cause a generalized block in retrograde vesicle-mediated transport, resulting in the hyper-accumulation of multiple lysosomal cargos. An important, yet oft
Publikováno v:
Journal of Pharmaceutical Sciences. 94:918-927
Prior to delivery to the patient, protein pharmaceuticals often come in contact with a variety of surfaces (e.g., syringes and stoppers), which are treated to facilitate processing or to inhibit protein binding. One such coating, silicone oil, has pr
Traditionally, proteins belonging to the ATP-binding cassette superfamily have been thought to function exclusively at the plasma membrane (PM) of cells. We have previously shown multidrug resistance-associated protein 1 (MRP1) to reside on the Golgi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5cc3be7684c35809fc51f1e2fa7ca9
https://europepmc.org/articles/PMC2596353/
https://europepmc.org/articles/PMC2596353/
Publikováno v:
Journal of pharmaceutical sciences. 96(4)
Amine-containing drugs represent a very important class of therapeutic agents, with the majority of all drugs containing at least one basic nitrogen. For many decades, it has been known that weakly basic compounds can be sequestered into acidic organ