Capturing functional epigenomes for insight into metabolic diseases

Autor: Allum, Fiona, Grundberg, Elin

Publikováno v: In Molecular Metabolism August 2020 38

Additional file 5: Figure S1. of Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome

Autor: Cheung, Warren, Xiaojian Shao, Morin, Andréanne, Siroux, Valérie, Kwan, Tony, Ge, Bing, Aïssi, Dylan, Chen, Lu, Vasquez, Louella, Allum, Fiona, Guénard, Frédéric, Bouzigon, Emmanuelle, Marie-Michelle Simon, Boulier, Elodie, Redensek, Adriana, Watt, Stephen, Avik Datta, Clarke, Laura, Flicek, Paul, Mead, Daniel, Paul, Dirk, Beck, Stephan, Bourque, Guillaume, Lathrop, Mark, Tchernof, André, Marie-Claude Vohl, Demenais, Florence, Pin, Isabelle, Downes, Kate, Stunnenberg, Hendrick, Soranzo, Nicole, Pastinen, Tomi, Grundberg, Elin

Validation using 450 k array. Figure S2. Detailed description of samples per cell type. (PDF 440 kb)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e61c0112e7e3069d899edbf2b9d48ab

Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants

Autor: Allum, Fiona, Shao, Xiaojian, Guénard, Frédéric, Simon, Marie Michelle, Busche, Stephan, Caron, Maxime, Lambourne, John, Lessard, Julie, Tandre, Karolina, Hedman, Åsa K., Kwan, Tony, Ge, Bing, Rönnblom, Lars, McCarthy, Mark I., Deloukas, Panos, Richmond, Todd, Burgess, Daniel, Spector, Timothy D., Tchernof, André, Marceau, Simon, Lathrop, Mark, Vohl, Marie Claude, Pastinen, Tomi, Grundberg, Elin, Ahmadi, Kourosh R., Ainali, Chrysanthi, Barrett, Amy, Bataille, Veronique, Bell, Jordana T., Buil, Alfonso, Dermitzakis, Emmanouil T., Dimas, Antigone S., Durbin, Richard, Glass, Daniel, Hassanali, Neelam, Ingle, Catherine, Knowles, David, Krestyaninova, Maria, Lindgren, Cecilia M., Lowe, Christopher E., Meduri, Eshwar, Di Meglio, Paola, Min, Josine L., Montgomery, Stephen B., Nestle, Frank O., Nica, Alexandra C., Nisbet, James, O'Rahilly, Stephen, Parts, Leopold, Potter, Simon, Sandling, Johanna, Sekowska, Magdalena, Shin, So Youn, Small, Kerrin S., Soranzo, Nicole, Surdulescu, Gabriela, Travers, Mary E., Tsaprouni, Loukia, Tsoka, Sophia, Wilk, Alicja, Yang, Tsun Po, Zondervan, Krina T.

Publikováno v: Nature Communications
Allum, F, Shao, X, Guénard, F, Simon, M M, Busche, S, Caron, M, Lambourne, J, Lessard, J, Tandre, K, Hedman, Å K, Kwan, T, Ge, B, Rönnblom, L, McCarthy, M I, Deloukas, P, Richmond, T, Burgess, D, Spector, T D, Tchernof, A, Marceau, S, Lathrop, M, Vohl, M C, Pastinen, T, Grundberg, E, Ahmadi, K R, Ainali, C, Barrett, A, Bataille, V, Bell, J T, Buil, A, Dermitzakis, E T, Dimas, A S, Durbin, R, Glass, D, Hassanali, N, Ingle, C, Knowles, D, Krestyaninova, M, Lindgren, C M, Lowe, C E, Meduri, E, Di Meglio, P, Min, J L, Montgomery, S B, Nestle, F O, Nica, A C, Nisbet, J, O'Rahilly, S, Parts, L, Potter, S, Sandling, J, Sekowska, M, Shin, S Y, Small, K S, Soranzo, N, Surdulescu, G, Travers, M E, Tsaprouni, L, Tsoka, S, Wilk, A, Yang, T P & Zondervan, K T 2015, ' Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants ', Nature Communications, vol. 6, 7211 . https://doi.org/10.1038/ncomms8211

Most genome-wide methylation studies (EWAS) of multifactorial disease traits use targeted arrays or enrichment methodologies preferentially covering CpG-dense regions, to characterize sufficiently large samples. To overcome this limitation, we presen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7634922a50a3e1cb9bf09ba13690e6d
http://europepmc.org/articles/PMC4544751

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Higher chylomicron remnants and LDL particle numbers associate with CD36SNPs and DNA methylation sites that reduce CD36[S]

Autor: Love-Gregory, Latisha, Kraja, Aldi T., Allum, Fiona, Aslibekyan, Stella, Hedman, Åsa K., Duan, Yanan, Borecki, Ingrid B., Arnett, Donna K., McCarthy, Mark I., Deloukas, Panos, Ordovas, Jose M., Hopkins, Paul N., Grundberg, Elin, Abumrad, Nada A.

Publikováno v: Journal of Lipid Research; December 2016, Vol. 57 Issue: 12 p2176-2184, 9p